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S

Sujatha M. Gopalakrishnan

AbbVie
H指数:21
被引数:1,376
浏览量:0

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Discovery of a tau-aggregate clearing compound that covalently targets P4HB

靶向P4HB并清除tau聚集物的共价化合物发现

Cell Chemical Biology
IF7.2
2025-10-060
PRE
Louis P. Conway; Michelle A. Estrada; Weichao Li; Stephen Walker; Benjamin Mielich-Süss; Anurupa Shrestha; Matthew Townsend; Jürgen Korffmann; Greg Potts; Janice Lee; Kenneth P. Robinson; Shiyao Wang; Brian Bierie; John R. Koenig; Phil Cox; Paul Richardson; Manisha Jhala; Becca McCloud; Sujatha Gopalakrishnan; Kevin Woller; Anil Vasudevan; Scott E. Warder; Shaun M. McLoughlin; Christopher G. Parker
Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2025-03-010
PRE
Goedken, Eric R.; Su, Zhi; Lipovsky, Alex; Kannan, Arun; Chu, Katharine L.; Ciura, Samantha; Foley, Sage E.; Frank, Kristine E.; Goess, Christian A.; Gopalakrishnan, Sujatha; Greszler, Stephen N.; Khan, Hasan A.; Leys, Laura J.; King, Jacob J.; Mathieu, Suzanne L.; Panchal, Sanjay C.; Paulsboe, Stephanie; Perham, Matt; Ramos, Ashley L.; Slivka, Peter F.; Srikumaran, Myron; Webster, Matthew P.; Wambeke, Emma L.; Zhu, Haizhong; Scott, Victoria E.; Mcgaraughty, Steve; Honore, Prisca
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-03-0620
PRE
Randolph, John T.; O'Connor, Matthew J.; Han, Fei; Hutchins, Charles W.; Siu, Y. Amy; Cho, Min; Zheng, Yunan; Hickson, Jonathan A.; Markley, Jana L.; Manaves, Vlasios; Algire, Mikkel; Baker, Kenton A.; Chapman, Alex M.; Gopalakrishnan, Sujatha M.; Panchal, Sanjay C.; Foster-Duke, Kelly; Stolarik, DeAnne F.; Kempf-Grote, Anita; Dammeier, Darby; Fossey, Stacey; Sun, Qi; Sun, Chaohong; Shen, Yu; Dart, Michael J.; Kati, Warren M.; Lai, Albert; Firestone, Ari J.; Kort, Michael E.
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
SCIENTIFIC REPORTS
IF3.9
2022-08-268
OAAI
Goedken, Eric R.; Argiriadi, Maria A.; Dietrich, Justin D.; Petros, Andrew M.; Krishnan, Navasona; Panchal, Sanjay C.; Qiu, Wei; Wu, Haihong; Zhu, Haizhong; Adams, Ashley M.; Bodelle, Pierre M.; Goguen, Lucas; Richardson, Paul L.; Slivka, Peter F.; Srikumaran, Myron; Upadhyay, Anup K.; Wu, Bainan; Judge, Russell A.; Vasudevan, Anil; Gopalakrishnan, Sujatha M.; Cox, Philip B.; Stoll, Vincent S.; Sun, Chaohong
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy
ACS CHEMICAL BIOLOGY
IF3.8
2022-02-2126
PRE
Malchow, Sven; Korepanova, Alla; Panchal, Sanjay C.; McClure, Ryan A.; Longenecker, Kenton L.; Qiu, Wei; Zhao, Hongyu; Cheng, Min; Guo, Jun; Klinge, Kelly L.; Trusk, Patricia; Pratt, Steven D.; Li, Tao; Kurnick, Matthew D.; Duan, Lishu; Shoemaker, Alex R.; Gopalakrishnan, Sujatha M.; Warder, Scott E.; Shotwell, J. Brad; Lai, Albert; Sun, Chaohong; Osuma, Augustine T.; Pappano, William N.
Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis
SCIENTIFIC REPORTS
IF3.9
2019-06-2455
OAAI
Todorovic, Viktor; Su, Zhi; Putman, C. Brent; Kakavas, Stevan J.; Salte, Katherine M.; McDonald, Heath A.; Wetter, Joseph B.; Paulsboe, Stephanie E.; Sun, Qi; Gerstein, Clare E.; Medina, Limary; Sielaff, Bernhard; Sadhukhan, Ramkrishna; Stockmann, Henning; Richardson, Paul L.; Qiu, Wei; Argiriadi, Maria A.; Henry, Rodger F.; Herold, J. Martin; Shotwell, J. Brad; McGaraughty, Steve P.; Honore, Prisca; Gopalakrishnan, Sujatha M.; Sun, Chaohong C.; Scott, Victoria E.
Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses
ACS CHEMICAL BIOLOGY
IF3.8
2019-04-0221
PREAI
Slivka, Peter F.; Hsieh, Chen-Lin; Lipovsky, Alex; Pratt, Steven D.; Locklear, John; Namovic, Marian T.; McDonald, Heath A.; Wetter, Joseph; Edelmayer, Rebecca; Hu, Min; Murphy, Erin; Domanus, Marc; Lu, Charles; Duggan, Ryan; King, Jacob; Scott, Victoria E.; Donnelly-Roberts, Diana; Slavin, Anthony; Gopalakrishnan, Sujatha; Chung, Namjin; Goedken, Eric R.
Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-11-0127
OAAI
Hobson, Adrian D.; Judge, Russell A.; Aguirre, Ana L.; Brown, Brian S.; Cui, Yifang; Ding, Ping; Dominguez, Eric; DiGiammarino, Enrico; Egan, David A.; Freiberg, Gail M.; Gopalakrishnan, Sujatha M.; Harris, Christopher M.; Honore, Marie P.; Kage, Karen L.; Kapecki, Nicolas J.; Ling, Christopher; Ma, Junli; Mack, Helmut; Mamo, Mulugeta; Maurus, Stefan; McRae, Bradford; Moore, Nigel S.; Muellery, Bernhard K.; Mueller, Reinhold; Namovic, Marian T.; Patel, Kaushal; Pratt, Steve D.; Putman, C. Brent; Queeney, Kara L.; Sarris, Kathy K.; Schaffter, Lisa M.; Stoll, Vincent; Vasudevan, Anil; Wang, Lei; Wang, Lu; Wirthl, William; Yacht, Kimberly
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-07-1338
PREAI
Jakob, Clarissa G.; Upadhyay, Anup K.; Donner, Pamela L.; Nicholl, Emily; Addo, Sadiya N.; Qiu, Wei; Ling, Christopher; Gopalakrishnan, Sujatha M.; Torrent, Maricel; Cepa, Steven P.; Shanley, Jason; Shoemaker, Alexander R.; Sun, Chaohong C.; Vasudevan, Anil; Woller, Kevin R.; Shotwell, J. Brad; Shaw, Bailin; Bian, Zhiguo; Hutti, Jessica E.

研究方向

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C
Chaohong Sun
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S
Sanjay C. Panchal
H 指数:19论文数:110被引数:2,698
W
Wei Qiu
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M
Murali Gopalakrishnan
H 指数:46论文数:183被引数:6,913
N
Nathaniel L. Elsen
H 指数:20论文数:97被引数:1,216
A
Anil Vasudevan
H 指数:33论文数:144被引数:2,690
F
Fan Pu
H 指数:19论文数:38被引数:1,290
J
John Malysz
H 指数:28论文数:99被引数:3,996
S
Stephen G. Walker
H 指数:28论文数:112被引数:3,735
A
Andrew J. Radosevich
H 指数:22论文数:101被引数:1,463