arrow
返回
K

Kelly R. Bales

Pfizer

71H指数
263论文数
2.2W被引数
收录论文 65
发表时间
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease临床候选PF-06648671的发现: 一种有效的 γ-分泌酶调节剂,用于治疗阿尔茨海默氏病
err2024-06-07
err0
PREAI
errPettersson, Martin; Johnson, Douglas S.; Humphrey, John M.; Am Ende, Christopher W.; Butler, Todd W.; Dorff, Peter H.; Efremov, Ivan V.; Evrard, Edelweiss; Green, Michael E.; Helal, Christopher J.; Kauffman, Gregory W.; Mullins, Patrick B.; Navaratnam, Thayalan; O'Donnell, Christopher J.; O'Sullivan, Theresa J.; Patel, Nandini C.; Stepan, Antonia F.; Stiff, Cory M.; Subramanyam, Chakrapani; Trapa, Patrick; Tran, Tuan P.; Vetelino, Beth Cooper; Yang, Eddie; Xie, Longfei; Pustilnik, Leslie R.; Steyn, Stefanus J.; Wood, Kathleen M.; Bales, Kelly R.; Hajos-Korcsok, Eva; Verhoest, Patrick R.
err分享
err收藏
Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains
err2019-07-09
err26
errOAAI
errXu, Jinbin; Sun, Jianjun; Perrin, Richard J.; Mach, Robert H.; Bales, Kelly R.; Morris, John C.; Benzinger, Tammie L. S.; Holtzman, David M.
err分享
err收藏
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
err2018-04-03
err35
PREAI
errO'Neill, Brian T.; Beck, Elizabeth M.; Butler, Christopher R.; Nolan, Charles E.; Gonzales, Cathleen; Zhang, Lei; Doran, Shawn D.; Lapham, Kimberly; Buzon, Leanne M.; Dutra, Jason K.; Barreiro, Gabriela; Hou, Xinjun; Martinez-Alsina, Luis A.; Rogers, Bruce N.; Villalobos, Anabella; Murray, John C.; Ogilvie, Kevin; LaChapelle, Erik A.; Chang, Cheng; Lanyon, Lorraine F.; Steppan, Claire M.; Robshaw, Ashley; Hales, Katherine; Boucher, Germaine G.; Pandher, Karamjeet; Houle, Christopher; Ambroise, Claude W.; Karanian, David; Riddell, David; Bales, Kelly R.; Brodney, Michael A.
err分享
err收藏
Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain
err2018-01-22
err17
PREAI
errZhang, Lei; Chen, Laigao; Dutra, Jason K.; Beck, Elizabeth M.; Nag, Sangram; Takano, Akihiro; Amini, Nahid; Arakawa, Ryosuke; Brodney, Michael A.; Buzon, Leanne M.; Doran, Shawn D.; Lanyon, Lorraine F.; McCarthy, Timothy J.; Bales, Kelly R.; Nolan, Charles E.; O'Neill, Brian T.; Schildknegt, Klaas; Halldin, Christer; Villalobos, Anabella
err分享
err收藏
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
err2016-01-04
err23
errOAAI
errDeming, Yuetiva; Xia, Jian; Cai, Yefei; Lord, Jenny; Del-Aguila, Jorge L.; Fernandez, Maria Victoria; Carrell, David; Black, Kathleen; Budde, John; Ma, ShengMei; Saef, Benjamin; Howells, Bill; Bertelsen, Sarah; Bailey, Matthew; Ridge, Perry G.; Holtzman, David; Morris, John C.; Bales, Kelly; Pickering, Eve H.; Lee, Jin-Moo; Heitsch, Laura; Kauwe, John; Goate, Alison; Piccio, Laura; Cruchaga, Carlos
err分享
err收藏
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin阿尔茨海默氏病的潜在内表型: 脑脊液簇蛋白
err2016-01-01
err50
errOAAI
errDeming, Yuetiva; Xia, Jian; Cai, Yefei; Lord, Jenny; Holmans, Peter; Bertelsen, Sarah; Holtzman, David; Morris, John C.; Bales, Kelly; Pickering, Eve H.; Kauwe, John; Goate, Alison; Cruchaga, Carlos
err分享
err收藏
Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity
errBRAIN
IF11.7
err2015-10-22
err53
errOAAI
errBales, Kelly R.; O'Neill, Sharon M.; Pozdnyakov, Nikolay; Pan, Feng; Caouette, David; Pi, YeQing; Wood, Kathleen M.; Volfson, Dmitri; Cirrito, John R.; Han, Byung-Hee; Johnson, Andrew W.; Zipfel, Gregory J.; Samad, Tarek A.
err分享
err收藏
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability
err2015-04-03
err34
errOAAI
errPettersson, Martin; Johnson, Douglas S.; Humphrey, John M.; Butler, Todd W.; Ende, Christopher W. Am; Fish, Benjamin A.; Green, Michael E.; Kauffman, Gregory W.; Mullins, Patrick B.; O'Donnell, Christopher J.; Stepan, Antonia F.; Stiff, Cory M.; Subramanyam, Chakrapani; Tran, Tuan P.; Vetelino, Beth Cooper; Yang, Eddie; Xie, Longfei; Bales, Kelly R.; Pustilnik, Leslie R.; Steyn, Stefanus J.; Wood, Kathleen M.; Verhoest, Patrick R.
err分享
err收藏
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation
err2014-10-23
err117
errOAAI
errKauwe, John S. K.; Bailey, Matthew H.; Ridge, Perry G.; Perry, Rachel; Wadsworth, Mark E.; Hoyt, Kaitlyn L.; Staley, Lyndsay A.; Karch, Celeste M.; Harari, Oscar; Cruchaga, Carlos; Ainscough, Benjamin J.; Bales, Kelly; Pickering, Eve H.; Bertelsen, Sarah; Fagan, Anne M.; Holtzman, David M.; Morris, John C.; Goate, Alison M.
err分享
err收藏
Phosphorylated Tau-Aβ42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimer's Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid
err2014-05-01
err79
errOAAI
errHarari, Oscar; Cruchaga, Carlos; Kauwe, John S. K.; Ainscough, Benjamin J.; Bales, Kelly; Pickering, Eve H.; Bertelsen, Sarah; Fagan, Anne M.; Holtzman, David M.; Morris, John C.; Goate, Alison M.
err分享
err收藏
Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ-Secretase Modulators
err2014-01-28
err32
PREAI
errPettersson, Martin; Johnson, Douglas S.; Subramanyam, Chakrapani; Bales, Kelly R.; Ende, Christopher W. Am; Fish, Benjamin A.; Green, Michael E.; Kauffman, Gregory W.; Mullins, Patrick B.; Navaratnam, Thayalan; Sakya, Subas M.; Stiff, Cory M.; Tran, Tuan P.; Xie, Longfei; Zhang, Liming; Pustilnik, Leslie R.; Vetelino, Beth C.; Wood, Kathleen M.; Pozdnyakov, Nikolay; Verhoest, Patrick R.; O'Donnell, Christopher J.
err分享
err收藏
γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin
err2013-04-01
err102
errOAAI
errPozdnyakov, Nikolay; Murrey, Heather E.; Crump, Christina J.; Pettersson, Martin; Ballard, T. Eric; Ende, Christopher W. Am; Ahn, Kwangwook; Li, Yue-Ming; Bales, Kelly R.; Johnson, Douglas S.
err分享
err收藏
Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses
err2012-08-01
err32
PREAI
errLu, Yasong; Riddell, David; Hajos-Korcsok, Eva; Bales, Kelly; Wood, Kathleen M.; Nolan, Charles E.; Robshaw, Ashley E.; Zhang, Liming; Leung, Louis; Becker, Stacey L.; Tseng, Elaine; Barricklow, Jason; Miller, Emily H.; Osgood, Sarah; O'Neill, Brian T.; Brodney, Michael A.; Johnson, Douglas S.; Pettersson, Martin
err分享
err收藏
Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimers disease
err2012-07-20
err176
errOAAI
errCruchaga, Carlos; Kauwe, John S. K.; Nowotny, Petra; Bales, Kelly; Pickering, Eve H.; Mayo, Kevin; Bertelsen, Sarah; Hinrichs, Anthony; Fagan, Anne M.; Holtzman, David M.; Morris, John C.; Goate, Alison M.
err分享
err收藏
Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment
err2011-11-15
err26
errOAAI
errHu, X.; Pickering, E. H.; Hall, S. K.; Naik, S.; Liu, Y. C.; Soares, H.; Katz, E.; Paciga, S. A.; Liu, W.; Aisen, P. S.; Bales, K. R.; Samad, T. A.; John, S. L.
err分享
err收藏
Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1基于哌啶乙酸的 γ-分泌酶调节剂直接与Presenilin-1结合
err2011-10-18
err68
errOAAI
errCrump, Christina J.; Fish, Benjamin A.; Castro, Suita V.; Chau, De-Ming; Gertsik, Natalya; Ahn, Kwangwook; Stiff, Cory; Pozdnyakov, Nikolay; Bales, Kelly R.; Johnson, Douglas S.; Li, Yue-Ming
err分享
err收藏
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance人类apoE亚型差异调节脑淀粉样 β 肽清除
err2011-06-29
err1.1K
errOAAI
errCastellano, Joseph M.; Kim, Jungsu; Stewart, Floy R.; Jiang, Hong; DeMattos, Ronald B.; Patterson, Bruce W.; Fagan, Anne M.; Morris, John C.; Mawuenyega, Kwasi G.; Cruchaga, Carlos; Goate, Alison M.; Bales, Kelly R.; Paul, Steven M.; Bateman, Randall J.; Holtzman, David M.
err分享
err收藏
Reduced levels of human apoE4 protein in an animal model of cognitive impairment
err2011-05-01
err108
PREAI
errSullivan, P. M.; Han, B.; Liu, F.; Mace, B. E.; Ervin, J. F.; Wu, S.; Koger, D.; Paul, S.; Bales, K. R.
err分享
err收藏
Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
err2008-05-01
err90
errOAAI
errRohe, Michael; Carlo, Anne-Sophie; Breyhan, Henning; Sporbert, Anje; Militz, Daniel; Schmidt, Vanessa; Wozny, Christian; Harmeier, Anja; Erdmann, Bettina; Bales, Kelly R.; Wolf, Susanne; Kempermann, Gerd; Paul, Steven M.; Schmitz, Dietmar; Bayer, Thomas A.; Willnow, Thomas E.; Andersen, Olav M.
err分享
err收藏
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
err2008-01-17
err362
errOAAI
errWahrle, Suzanne E.; Jiang, Hong; Parsadanian, Maia; Kim, Jungsu; Li, Aimin; Knoten, Amanda; Jain, Sanjay; Hirsch-Reinshagen, Veronica; Wellington, Cheryl L.; Bales, Kelly R.; Paul, Steven M.; Holtzman, David M.
err分享
err收藏