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收藏分享 收藏 Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma肺eqtl有助于揭示哮喘的分子基础
Hao, Ke; Bosse, Yohan; Nickle, David C.; Pare, Peter D.; Postma, Dirkje S.; Laviolette, Michel; Sandford, Andrew; Hackett, Tillie L.; Daley, Denise; Hogg, James C.; Elliott, W. Mark; Couture, Christian; Lamontagne, Maxime; Brandsma, Corry-Anke; van den Berge, Maarten; Koppelman, Gerard; Reicin, Alise S.; Nicholson, Donald W.; Malkov, Vladislav; Derry, Jonathan M.; Suver, Christine; Tsou, Jeffrey A.; Kulkarni, Amit; Zhang, Chunsheng; Vessey, Rupert; Opiteck, Greg J.; Curtis, Sean P.; Timens, Wim; Sin, Don D. 分享 收藏 分享 收藏 Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease可逆caspase-3抑制剂M826在亨廷顿氏病大鼠丙二酸模型中的神经保护作用Toulmond, S; Tang, K; Bureau, Y; Ashdown, H; Degen, S; O'Donnell, R; Tam, J; Han, YX; Colucci, J; Giroux, A; Zhu, YX; Boucher, M; Pikounis, B; Xanthoudakis, S; Roy, S; Rigby, M; Zamboni, R; Robertson, GS; Ng, GYK; Nicholson, DW; Flückiger, JP 分享 收藏 分享 收藏 分享 收藏 分享 收藏 L-454,560, a potent and selective PDE4 inhibitor with in vitro efficacy in animal models of asthma and cognitionL-454，560，一种有效的选择性PDE4抑制剂，在哮喘和认知动物模型中具有体外功效Huang, Z.; Dias, R.; Jones, T.; Liu, S.; Styhler, A.; Claveau, D.; Otu, F.; Ng, K.; Laliberte, F.; Zhang, L.; Goetghebeur, P.; Abraham, W. M.; Macdonald, D.; Dub, D.; Gallant, M.; Lacombe, P.; Girard, Y.; Young, R. N.; Turner, M. J.; Nicholson, D. W.; Mancini, J. A. 分享 收藏 分享 收藏 Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis4-[2-(3，4-双-二氟甲氧基苯基)-2-[4-(1,1，1,3，3，3，3-六氟-2-羟基丙-2-基)-苯基]-乙基]-3-甲基吡啶-1-氧化物 (L-826，141) 产生的外周磷酸二酯酶4抑制预防实验性自身免疫性脑脊髓炎Moore, C. S.; Earl, N.; Frenette, R.; Styhler, A.; Mancini, J. A.; Nicholson, D. W.; Hebb, A. L. O.; Owens, T.; Robertson, G. S. 分享 收藏 分享 收藏 分享 收藏 Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-{2-(3,4-bis-difluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor通过L-826，141 [4-{2-(3，4-二氟甲氧基苯基)-2-{4-(1,1，1,3，3，3-六氟-2-羟基丙-2-基)-苯基]-乙基}-3-甲基吡啶-1-氧化物]，强效选择性磷酸二酯酶4抑制剂Claveau, D; Chen, SL; O'Keefe, S; Zaller, DM; Styhler, A; Liu, S; Huang, Z; Nicholson, DW; Mancini, JA 分享 收藏 A caspase active site probe reveals high fractional inhibition needed to block DNA fragmentationMéthot, N; Vaillancourt, JP; Huang, JQ; Colucci, J; Han, YX; Ménard, S; Zamboni, R; Toulmond, S; Nicholson, DW; Roy, S 分享 收藏 Reducing the peptidyl features of caspase-3 inhibitors: A structural analysis减少caspase-3抑制剂的肽基特征: 结构分析Becker, JW; Rotonda, J; Soisson, SM; Aspiotis, R; Bayly, C; Francoeur, S; Gallant, M; Garcia-Calvo, M; Giroux, A; Grimm, E; Han, YX; McKay, D; Nicholson, DW; Peterson, E; Renaud, J; Roy, S; Thornberry, N; Zamboni, R 分享 收藏 Solid phase synthesis of selective caspase-3 peptide inhibitors选择性caspase-3肽抑制剂的固相合成Grimm, EL; Roy, B; Aspiotis, R; Bayly, CI; Nicholson, DW; Rasper, DM; Renaud, J; Roy, S; Tam, J; Tawa, P; Vaillancourt, JP; Xanthoudakis, S; Zamboni, RJ 分享 收藏 Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics半胱天冬酶抑制剂对脓毒症大鼠凋亡标志物的差异功效及其对治疗药物的部分抑制要求的影响Méthot, N; Huang, JQ; Coulombe, N; Vaillancourt, JP; Rasper, D; Tam, J; Han, YX; Colucci, J; Zamboni, R; Xanthoudakis, S; Toulmond, S; Nicholson, DW; Roy, S 分享 收藏 分享 收藏 分享 收藏 
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