未登录 TAK-994 mechanistic investigation into drug-induced liver injury 药物性肝损伤的TAK-994机制研究 Shinozawa, Tadahiro; Miyamoto, Kazumasa; Baker, Kevin S.; Faber, Samantha C.; Flores, Ramon; Uetrecht, Jack; von Hehn, Christian; Yukawa, Tomoya; Tohyama, Kimio; Kadali, Harisha; von Grotthuss, Marcin; Sudo, Yusuke; Smith, Erin N.; Diogo, Dorothee; Zhu, Andy Z. X.; Dragan, Yvonne; Cebers, Gvido; Wagoner, Matthew P. 分享 收藏
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Polygenic architecture informs potential vulnerability to drug-induced liver injury Koido, Masaru; Kawakami, Eri; Fukumura, Junko; Noguchi, Yui; Ohori, Momoko; Nio, Yasunori; Nicoletti, Paola; Aithal, Guruprasad P.; Daly, Ann K.; Watkins, Paul B.; Anayama, Hisashi; Dragan, Yvonne; Shinozawa, Tadahiro; Takebe, Takanori 分享 收藏
An Integrated Multi-Omics Analysis Defines Key Pathway Alterations in a Diet-Induced Obesity Mouse Model 整合的多组学分析定义了饮食诱导的肥胖小鼠模型中的关键途径变化 Sundekilde, Ulrik K.; Yde, Christian C.; Honore, Anders H.; Rae, Jessica M. Caverly; Burns, Frank R.; Mukerji, Pushkor; Mawn, Michael P.; Stenman, Lotta; Dragan, Yvonne; Glover, Kyle; Jensen, Henrik M. 分享 收藏
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury Longo, Diane M.; Woodhead, Jeffrey L.; Walker, Paul; Heredi-Szabo, Krisztina; Mogyorosi, Karoly; Wolenski, Francis S.; Dragan, Yvonne P.; Mosedale, Merrie; Siler, Scott Q.; Watkins, Paul B.; Howell, Brett A. 分享 收藏
Development of dietary soluble fibres by enzymatic synthesis and assessment of their digestibility in in vitro, animal and randomised clinical trial models Hasselwander, Oliver; DiCosimo, Robert; You, Zheng; Cheng, Qiong; Rothman, Steven C.; Suwannakham, Supaporn; Baer, Zachary C.; Roesch, Brian M.; Ruebling-Jass, Kristin D.; Lai, Jian Ping; Hurteau, Richard E.; Marquez, Mario L.; Kopatsis, Alexander D.; Ouwehand, Arthur C.; Forssten, Sofia D.; Mukerji, Pushkor; Rae, Jessica M. Caverly; Dragan, Yvonne P.; Damewood, James R.; Tiihonen, Kirsti; Ibarra, Alvin 分享 收藏
Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury Fasiglifam (TAK-875) 改变大鼠和狗的胆汁酸稳态: 药物引起的肝损伤的潜在原因 Wolenski, Francis S.; Zhu, Andy Z. X.; Johnson, Mike; Yu, Shaoxia; Moriya, Yuu; Ebihara, Takuya; Csizmadia, Vilmos; Grieves, Jessica; Paton, Martin; Liao, Mingxiang; Gemski, Christopher; Pan, Liping; Vakilynejad, Majid; Dragan, Yvonne P.; Chowdhury, Swapan K.; Kirby, Patrick J. 分享 收藏
Doxorubicin: Comparison between 3-h continuous and bolus intravenous administration paradigms on cardio-renal axis, mitochondrial sphingolipids and pathology Kamendi, Harriet; Zhou, Ying; Crosby, Meredith; Keirstead, Natalie; Snow, Debra; Bentley, Patricia; Patel, Nilaben; Barthlow, Herbert; Luo, Wenli; Dragan, Yvonne; Bialecki, Russell 分享 收藏
Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers Keirstead, Natalie D.; Wagoner, Matthew P.; Bentley, Patricia; Blais, Marie; Brown, Crystal; Cheatham, Letitia; Ciaccio, Paul; Dragan, Yvonne; Ferguson, Douglas; Fikes, Jim; Galvin, Melanie; Gupta, Anshul; Hale, Michael; Johnson, Nakpangi; Luo, Wenli; McGrath, Frank; Pietras, Mark; Price, Sally; Sathe, Abhishek G.; Sasaki, Jennifer C.; Snow, Debra; Walsky, Robert L.; Kern, Gunther 分享 收藏
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What Do We Need to Know prior to Thinking about Incorporating an Epigenetic Evaluation into Safety Assessments?2 Goodman, Jay I.; Augustine, Karen A.; Cunnningham, Michael L.; Dixon, Darlene; Dragan, Yvonne P.; Falls, James Greg; Rasoulpour, Reza J.; Sills, Robert C.; Storer, Richard D.; Wolf, Douglas C.; Pettit, Syril D. 分享 收藏
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Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat Fielden, Mark R.; Nie, Alex; McMillian, Michael; Elangbam, Chandi S.; Trela, Bruce A.; Yang, Yi; Dunn, Robert T., II; Dragan, Yvonne; Fransson-Stehen, Ronny; Bogdanffy, Matthew; Adams, Stephen P.; Foster, William R.; Chen, Shen-Jue; Rossi, Phil; Kasper, Peter; Jacobson-Kram, David; Tatsuoka, Kay S.; Wier, Patrick J.; Gollu, Jeremy; Halbert, Donald N.; Roter, Alan; Young, Jamie K.; Sina, Joseph F.; Marlowe, Jennifer; Martus, Hans-Joerg; Aubrecht, Jiri; Olaharski, Andrew J.; Roome, Nigel; Nioi, Paul; Pardo, Ingrid; Snyder, Ron; Perry, Richard; Lord, Peter; Mattes, William; Car, Bruce D. 分享 收藏
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Rat toxicogenomic study reveals analytical consistency across microarray platforms Guo, Lei; Lobenhofer, Edward K.; Wang, Charles; Shippy, Richard; Harris, Stephen C.; Zhang, Lu; Mei, Nan; Chen, Tao; Herman, Damir; Goodsaid, Federico M.; Hurban, Patrick; Phillips, Kenneth L.; Xu, Jun; Deng, Xutao; Sun, Yongming Andrew; Tong, Weida; Dragan, Yvonne P.; Shi, Leming 分享 收藏
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