未登录 Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 有效，有效，口服可用的抗疟血浆蛋白酶X抑制剂的发现和表征以及UCB7362的临床前安全性评估 Lowe, Martin A. .; Cardenas, Alvaro; Valentin, Jean-Pierre; Zhu, Zhaoning; Abendroth, Jan; Castro, Jose L.; Class, Reiner; Delaunois, Annie; Fleurance, Renaud; Gerets, Helga; Gryshkova, Vitalina; King, Lloyd; Lorimer, Donald D.; MacCoss, Malcolm; Rowley, Julian H.; Rosseels, Marie-Luce; Royer, Leandro; Taylor, Richard D.; Wong, Melanie; Zaccheo, Oliver; Chavan, Vishal P.; Ghule, Gokul A. .; Tapkir, Bapusaheb K.; Burrows, Jeremy N.; Duffey, Maelle; Rottmann, Matthias; Wittlin, Sergio; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Striepen, Josefine; Fairhurst, Kate J.; Yeo, Tomas; Fidock, David A. .; Cowman, Alan F.; Favuzza, Paola; Crespo-Fernandez, Benigno; Javier Gamo, Francisco; Goldberg, Daniel E.; Soldati-Favre, Dominique; Laleu, Benoit; de Haro, Teresa 分享 收藏
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model Yant, Stephen R.; Mulato, Andrew; Hansen, Derek; Tse, Winston C.; Niedziela-Majka, Anita; Zhang, Jennifer R.; Stepan, George J.; Jin, Debi; Wong, Melanie H.; Perreira, Jill M.; Singer, Eric; Papalia, Giuseppe A.; Hu, Eric Y.; Zheng, Jim; Lu, Bing; Schroeder, Scott D.; Chou, Kevin; Ahmadyar, Shekeba; Liclican, Albert; Yu, Helen; Novikov, Nikolai; Paoli, Eric; Gonik, Daniel; Ram, Renee R.; Hung, Magdeleine; McDougall, William M.; Brass, Abraham L.; Sundquist, Wesley I.; Cihlar, Tomas; Link, John O. 分享 收藏
ASK1 contributes to fibrosis and dysfunction in mode of kidney disease Liles, John T.; Corkey, Britton K.; Nolte, Gregory T.; Budas, Grant R.; Lansdon, Eric B.; Hinojosa-Kirschenbaum, Ford; Badal, Shawn S.; Lee, Michael; Schultz, Brian E.; Wise, Sarah; Pendem, Swetha; Graupe, Michael; Castonguay, Laurie; Koch, Keith A.; Wong, Melanie H.; Papalia, Giuseppe A.; French, Dorothy M.; Sullivan, Theodore; Huntzicker, Erik G.; Ma, Frank Y.; Nikolic-Paterson, David J.; Altuhaifi, Tareq; Yang, Haichun; Fogo, Agnes B.; Breckenridge, David G. 分享 收藏
Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9 Appleby, Todd C.; Greenstein, Andrew E.; Hung, Magdeleine; Liclican, Albert; Velasquez, Maile; Villasenor, Armando G.; Wang, Ruth; Wong, Melanie H.; Liu, Xiaohong; Papalia, Giuseppe A.; Schultz, Brian E.; Sakowicz, Roman; Smith, Victoria; Kwon, Hyock Joo 分享 收藏
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A Steadman, Victoria A.; Pettit, Simon B.; Poullennec, Karine G.; Lazarides, Linos; Keats, Andrew J.; Dean, David K.; Stanway, Steven J.; Austin, Carol A.; Sanvoisin, Jonathan A.; Watt, Gregory M.; Fliri, Hans G.; Liclican, Albert C.; Jin, Debi; Wong, Melanie H.; Leavitt, Stephanie A.; Lee, Yu-Jen; Tian, Yang; Frey, Christian R.; Appleby, Todd C.; Schmitz, Uli; Jansa, Petr; Mackman, Richard L.; Schultz, Brian E. 分享 收藏
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer Colley, Helen E.; Muthana, Munitta; Danson, Sarah J.; Jackson, Lucinda V.; Brett, Matthew L.; Harrison, Joanne; Coole, Sean F.; Mason, Daniel P.; Jennings, Luke R.; Wong, Melanie; Tulasi, Vamshi; Norman, Dennis; Lockey, Peter M.; Williams, Lynne; Dossetter, Alexander G.; Griffen, Edward J.; Thompson, Mark J. 分享 收藏
Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ Idelalisib与磷酸肌醇3-激酶 δ 结合的结构，生化和生物物理表征 Somoza, John R.; Koditek, David; Villasenor, Armando G.; Novikov, Nikolai; Wong, Melanie H.; Liclican, Albert; Xing, Weimei; Lagpacan, Leanna; Wang, Ruth; Schultz, Brian E.; Papalia, Giuseppe A.; Samuel, Dharmaraj; Lad, Latesh; McGrath, Mary E. 分享 收藏
Antibodies to TWEAK Receptor Inhibit Human Tumor Growth through Dual Mechanisms Culp, Patricia A.; Choi, Donghee; Zhang, Yongke; Yin, Johnny; Seto, Pui; Ybarra, Suzanne E.; Su, Mian; Sho, Mien; Steinle, Roxanne; Wong, Melanie H. L.; Evangelista, Ferdinand; Grove, Jennifer; Cardenas, Marie; James, Marjorie; Hsi, Eric D.; Chao, Debra T.; Powers, David B.; Ramakrishnan, Vanitha; Dubridge, Robert 分享 收藏
CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma CS1，一个潜在的治疗性抗体新靶点，用于治疗多发性骨髓瘤 Hsi, Eric D.; Steinle, Roxanne; Balasa, Balaji; Szmania, Susann; Draksharapu, Aparna; Shum, Benny P.; Huseni, Mahrukh; Powers, David; Nanisetti, Amulya; Zhang, Yin; Rice, Audie G.; van Abbema, Anne; Wong, Melanie; Liu, Gao; Zhan, Fenghuang; Dillon, Myles; Chen, Shihao; Rhodes, Susan; Fuh, Franklin; Tsurushita, Naoya; Kumar, Shankar; Vexler, Vladimir; Shaughnessy, John D., Jr.; Barlogie, Bart; van Rhee, Frits; Hussein, Mohamad; Afar, Daniel E. H.; Williams, Marna B. 分享 收藏
A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo Bhaskar, Vinay; Zhang, Dong; Fox, Melvin; Seto, Pui; Wong, Melanie H. L.; Wales, Pauline E.; Powers, David; Chao, Debra T.; DuBridge, Robert B.; Ramakrishnan, Vanitha 分享 收藏
Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits Bhaskar, Vinay; Fox, Melvin; Breinberg, Danna; Wong, Melanie H-L; Wales, Pauline E.; Rhodes, Susan; DuBridge, Robert B.; Ramakrishnan, Vanitha 分享 收藏
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase Jackson, SA; Sahni, S; Lee, L; Luo, YY; Nieduzak, TR; Liang, GY; Chiang, YL; Collar, N; Fink, D; He, W; Laoui, A; Merrill, J; Boffey, R; Crackett, P; Rees, B; Wong, M; Guilloteau, JP; Mathieu, M; Rebello, SS 分享 收藏
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Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer Henshall, SM; Afar, DEH; Rasiah, KK; Horvath, LG; Gish, K; Caras, I; Ramakrishnan, V; Wong, M; Jeffry, U; Kench, JG; Quinn, DI; Turner, JJ; Delprado, W; Lee, CS; Golovsky, D; Brenner, PC; O'Neill, GF; Kooner, R; Stricker, PD; Grygiel, JJ; Mack, DH; Sutherland, RL 分享 收藏
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