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Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers Acker, Michael G.; Chen, Ying-Nan P.; LaMarche, Matthew J.; Chan, Ho Man; Fekkes, Peter; Garcia-Fortanet, Jorge; LaRochelle, Jonathan R.; Antonakos, Brandon; Chen, Christine Hiu-Tung; Chen, Zhuoliang; Cooke, Vesselina G.; Dobson, Jason R.; Deng, Zhan; Feng, Fei; Firestone, Brant; Fodor, Michelle; Fridrich, Cary; Gao, Hui; Hao, Huai-Xiang; Jacob, Jaison; Ho, Samuel; Hsiao, Kathy; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Larrow, Jay; La Bonte, Laura R.; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Meyer, Matthew J.; Palermo, Mark; Pu, Minying; Price, Edmund; Shakya, Subarna; Shultz, Michael D.; Venkatesan, Kavitha; Wang, Ping; Warmuth, Markus; Williams, Sarah; Yang, Guizhi; Yuan, Jing; Zhang, Ji-Hu; Zhu, Ping; Blacklow, Stephen C.; Ramsey, Timothy; Keen, Nicholas J.; Sellers, William R.; Stams, Travis; Fortin, Pascal D. 分享 收藏
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to marked dependence on PRMT5 Mavrakis, Konstantinos; McDonald, E. Robert, III; Schlabach, Michael R.; Billy, Eric; Hoffman, Gregory R.; deWeck, Antoine; Ruddy, David A.; Venkatesan, Kavitha; McAllister, Greg; deBeaumont, Rosalie; Ho, Samuel; Liu, Yue; Yan-Neale, Yan; Yang, Guizhi; Lin, Fallon; Yin, Hong; Gao, Hui; Kipp, David Randal; Zhao, Songping; McNamara, Joshua T.; Sprague, Elizabeth R.; Cho, Young Shin; Gu, Justin; Crawford, Ken; Capka, Vladimir; Hurov, Kristen; Porter, Jeffrey A.; Tallarico, John; Mickanin, Craig; Lees, Emma; Pagliarini, Raymond; Keen, Nicholas; Schmelzle, Tobias; Hofmann, Francesco; Stegmeier, Frank; Sellers, William R. 分享 收藏
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response 使用患者来源的肿瘤异种移植物进行高通量筛选以预测临床试验药物反应 Gao, Hui; Korn, Joshua M.; Ferretti, Stephane; Monahan, John E.; Wang, Youzhen; Singh, Mallika; Zhang, Chao; Schnell, Christian; Yang, Guizhi; Zhang, Yun; Balbin, O. Alejandro; Barbe, Stephanie; Cai, Hongbo; Casey, Fergal; Chatterjee, Susmita; Chiang, Derek Y.; Chuai, Shannon; Cogan, Shawn M.; Collins, Scott D.; Dammassa, Ernesta; Ebel, Nicolas; Embry, Millicent; Green, John; Kauffmann, Audrey; Kowa, Colleen; Leary, Rebecca J.; Lehar, Joseph; Liang, Ying; Loo, Alice; Lorenzana, Edward; McDonald, E. Robert, III; McLaughlin, Margaret E.; Merkin, Jason; Meyer, Ronald; Naylor, Tara L.; Patawaran, Montesa; Reddy, Anupama; Roeelli, Claudia; Ruddy, David A.; Salangsang, Fernando; Santacroce, Francesca; Singh, Angad P.; Tang, Yan; Tinetto, Walter; Tobler, Sonja; Velazquez, Roberto; Venkatesan, Kavitha; Von Arx, Fabian; Wang, Hui Qin; Wang, Zongyao; Wiesmann, Marion; Wyss, Daniel; Xu, Fiona; Bitter, Hans; Atadja, Peter; Lees, Emma; Hofmann, Francesco; Li, En; Keen, Nicholas; Cozens, Robert; Jensen, Michael Rugaard; Pryer, Nancy K.; Williams, Juliet A.; Sellers, William R. 分享 收藏
A gene signature composed of 13 p53 target genes predicts for response to NVP-CGM097, a novel p53-Mdm2 inhibitor, in cell lines and in human primary tumor xenograft models Jeay, Sebastien; Gaulis, Swann; Ferretti, Stephane; Albrecht, Genevieve; Barys, Louise; Guthy, Daniel; Halilovic, Ensar; Ito, Moriko; Murakami, Masato; Pornon, Astrid; Ruetz, Stephan; Venkatesan, Kavitha; Yu, Jianjun; Jensen, Michael; Wiesmann, Marion; Wuerthner, Jens; Graus-Porta, Diana 分享 收藏
Global chromatin profiling reveals NSD2 mutation in pediatric ALL Chan, Ho Man; Jaffe, Jacob D.; Wang, Yan; Zhang, Jinghui; Huether, Robert; Kryukov, Gregory V.; Bhang, Hyo-eun C.; Taylor, Jordan E.; Hu, Min; Englund, Nathan P.; Yan, Feng; Wang, Zhaofu; McDonald, E. Robert, III; Wei, Lei; Ma, Jing; Easton, John; Yu, Zhengtian; Debeaumount, Rosalie; Gibaja, Veronica; Venkatesan, Kavitha; Schlegel, Robert; Sellers, William R.; Keen, Nicholas; Liu, Jun; Caponigro, Giordano; Barretina, Jordi; Cooke, Vesselina G.; Mullighan, Charles; Carr, Steven A.; Downing, James R.; Garraway, Levi A.; Stegmeier, Frank 分享 收藏
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia Jaffe, Jacob D.; Wang, Yan; Chan, Ho Man; Zhang, Jinghui; Huether, Robert; Kryukov, Gregory V.; Bhang, Hyo-eun C.; Taylor, Jordan E.; Hu, Min; Englund, Nathan P.; Yan, Feng; Wang, Zhaofu; McDonald, E. Robert, III; Wei, Lei; Ma, Jing; Easton, John; Yu, Zhengtian; deBeaumount, Rosalie; Gibaja, Veronica; Venkatesan, Kavitha; Schlegel, Robert; Sellers, William R.; Keen, Nicholas; Liu, Jun; Caponigro, Giordano; Barretina, Jordi; Cooke, Vesselina G.; Mullighan, Charles; Carr, Steven A.; Downing, James R.; Garraway, Levi A.; Stegmeier, Frank 分享 收藏
FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor FGFR遗传改变预测对选择性泛FGFR抑制剂NVP-BGJ398的敏感性 Guagnano, Vito; Kauffmann, Audrey; Woehrle, Simon; Stamm, Christelle; Ito, Moriko; Barys, Louise; Pornon, Astrid; Yao, Yao; Li, Fang; Zhang, Yun; Chen, Zhi; Wilson, Christopher J.; Bordas, Vincent; Le Douget, Mickael; Gaither, L. Alex; Borawski, Jason; Monahan, John E.; Venkatesan, Kavitha; Bruemmendorf, Thomas; Thomas, David M.; Garcia-Echeverria, Carlos; Hofmann, Francesco; Sellers, William R.; Graus-Porta, Diana 分享 收藏
Integrative analysis of the Cancer Cell Line Encyclopedia reveals genetic and transcriptional predictors of compound sensitivity Stransky, Nicolas; Kryukov, Gregory V.; Caponigro, Giordano; Barretina, Jordi; Venkatesan, Kavitha; Margolin, Adam A.; Wilson, Christopher J.; Lehar, Joseph; Jones, Michael D.; Palescandolo, Emanuele; Sougnez, Carrie; Onofrio, Robert C.; MacConaill, Laura; Ardlie, Kristin; Golub, Todd R.; Morrissey, Michael; Selers, William R.; Schlegel, Robert; Garraway, Levi A. 分享 收藏
Patient stratification strategies for NVP-BGJ398, a selective pan-FGFR inhibitor in phase I clinical trials Porta, Diana Graus; Guagnano, Vito; Stamm, Christelle; Woehrle, Simon; Kauffmann, Audrey; Yao, Yao; Brummendorf, Thomas; Bordas, Vincent; Le Douget, Mickael; Zhang, Yun; Chen, Zhi; Ito, Moriko; Li, Fang; Monahan, John; Gaither, Alex; Borawski, Jason; Wilson, Christopher J.; Venkatesan, Kavitha; Hofmann, Francesco; Sellers, William 分享 收藏
Literature-curated protein interaction datasets (vol 6, pg 39, 2009) Cusick, Michael E.; Yu, Haiyuan; Smolyar, Alex; Venkatesan, Kavitha; Carvunis, Anne-Ruxandra; Simonis, Nicolas; Rual, Jean-Francois; Borick, Heather; Braun, Pascal; Dreze, Matija; Vandenhaute, Jean; Galli, Mary; Yazaki, Junshi; Hill, David E.; Ecker, Joseph R.; Roth, Frederick P.; Vidal, Marc 分享 收藏
Edgetic perturbation models of human inherited disorders 人类遗传性疾病的edgic扰动模型 Zhong, Quan; Simonis, Nicolas; Li, Qian-Ru; Charloteaux, Benoit; Heuze, Fabien; Klitgord, Niels; Tam, Stanley; Yu, Haiyuan; Venkatesan, Kavitha; Mou, Danny; Swearingen, Venus; Yildirim, Muhammed A.; Yan, Han; Dricot, Amelle; Szeto, David; Lin, Chenwei; Hao, Tong; Fan, Changyu; Milstein, Stuart; Dupuy, Denis; Brasseur, Robert; Hill, David E.; Cusick, Michael E.; Vidal, Marc 分享 收藏
Literature-curated protein interaction datasets Cusick, Michael E.; Yu, Haiyuan; Smolyar, Alex; Venkatesan, Kavitha; Carvunis, Anne-Ruxandra; Simonis, Nicolas; Rual, Jean-Francois; Borick, Heather; Braun, Pascal; Dreze, Matija; Vandenhaute, Jean; Galli, Mary; Yazaki, Junshi; Hill, David E.; Ecker, Joseph R.; Roth, Frederick P.; Vidal, Marc 分享 收藏
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network Simonis, Nicolas; Rual, Jean-Francois; Carvunis, Anne-Ruxandra; Tasan, Murat; Lemmens, Irma; Hirozane-Kishikawa, Tomoko; Hao, Tong; Sahalie, Julie M.; Venkatesan, Kavitha; Gebreab, Fana; Cevik, Sebiha; Klitgord, Niels; Fan, Changyu; Braun, Pascal; Li, Ning; Ayivi-Guedehoussou, Nono; Dann, Elizabeth; Bertin, Nicolas; Szeto, David; Dricot, Ameli; Yildirim, Muhammed A.; Lin, Chenwei; de Smet, Anne-Sophie; Kao, Huey-Ling; Simon, Christophe; Smolyar, Alex; Ahn, Jin Sook; Tewari, Muneesh; Boxem, Mike; Milstein, Stuart; Yu, Haiyuan; Dreze, Matija; Vandenhaute, Jean; Gunsalus, Kristin C.; Cusick, Michael E.; Hill, David E.; Tavernier, Jan; Roth, Frederick P.; Vidal, Marc 分享 收藏
An empirical framework for binary interactome mapping Venkatesan, Kavitha; Rual, Jean-Francois; Vazquez, Alexei; Stelzl, Ulrich; Lemmens, Irma; Hirozane-Kishikawa, Tomoko; Hao, Tong; Zenkner, Martina; Xin, Xiaofeng; Goh, Kwang-Il; Yildirim, Muhammed A.; Simonis, Nicolas; Heinzmann, Kathrin; Gebreab, Fana; Sahalie, Julie M.; Cevik, Sebiha; Simon, Christophe; de Smet, Anne-Sophie; Dann, Elizabeth; Smolyar, Alex; Vinayagam, Arunachalam; Yu, Haiyuan; Szeto, David; Borick, Heather; Dricot, Amelie; Klitgord, Niels; Murray, Ryan R.; Lin, Chenwei; Lalowski, Maciej; Timm, Jan; Rau, Kirstin; Boone, Charles; Braun, Pascal; Cusick, Michael E.; Roth, Frederick P.; Hill, David E.; Tavernier, Jan; Wanker, Erich E.; Barabasi, Albert-Laszlo; Vidal, Marc 分享 收藏
An experimentally derived confidence score for binary protein-protein interactions Braun, Pascal; Tasan, Murat; Dreze, Matija; Barrios-Rodiles, Miriam; Lemmens, Irma; Yu, Haiyuan; Sahalie, Julie M.; Murray, Ryan R.; Roncari, Luba; de Smet, Anne-Sophie; Venkatesan, Kavitha; Rual, Jean-Francois; Vandenhaute, Jean; Cusick, Michael E.; Pawson, Tony; Hill, David E.; Tavernier, Jan; Wrana, Jeffrey L.; Roth, Frederick P.; Vidal, Marc 分享 收藏
Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans Dupuy, Denis; Bertin, Nicolas; Hidalgo, Cesar A.; Venkatesan, Kavitha; Tu, Domena; Lee, David; Rosenberg, Jennifer; Svrzikapa, Nenad; Blanc, Aurelie; Carnec, Alain; Carvunis, Anne-Ruxandra; Pulak, Rock; Shingles, Jane; Reece-Hoyes, John; Hunt-Newbury, Rebecca; Viveiros, Ryan; Mohler, William A.; Tasan, Murat; Roth, Frederick P.; Le Peuch, Christian; Hope, Ian A.; Johnsen, Robert; Moerman, Donald G.; Barabasi, Albert-Laszlo; Baillie, David; Vidal, Marc 分享 收藏
Epstein-Barr virus and virus human protein interaction maps Epstein-barr病毒和病毒的人类蛋白质相互作用图 Calderwood, Michael A.; Venkatesan, Kavitha; Xing, Li; Chase, Michael R.; Vazquez, Alexel; Holthaus, Amy M.; Ewence, Alexandra E.; Li, Ning; Hirozane-Kishikawa, Tomoko; Hill, David E.; Vidal, Marc; Kieff, Elliott; Johannsen, Eric 分享 收藏
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