Josephine Lai - Publications, H-index & Citations

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

IF3

2016-01-01

OAAI

Deekonda, Srinivas; Rankin, David; Davis, Peg; Lai, Josephine; Vanderah, Todd. W.; Porecca, Frank; Hruby, Victor J.

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - Neurokinin-1 antagonist peptidomimetics

IF3

2015-09-01

OAAI

Deekonda, Srinivas; Wugalter, Lauren; Kulkarni, Vinod; Rankin, David; Largent-Milnes, Tally M.; Davis, Peg; Bassirirad, Neemah M.; Lai, Josephine; Vanderah, Todd W.; Porreca, Frank; Hruby, Victor J.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2015-03-01

OAAI

Guillemyn, Karel; Kleczkowska, Patrycia; Lesniak, Anna; Dyniewicz, Jolanta; Van der Poorten, Olivier; Van den Eynde, Isabelle; Keresztes, Attila; Varga, Eva; Lai, Josephine; Porreca, Frank; Chung, Nga N.; Lemieux, Carole; Mika, Joanna; Rojewska, Ewelina; Makuch, Wioletta; Van Duppen, Joost; Przewlocka, Barbara; Vanden Broeck, Jozef; Lipkowski, Andrzej W.; Schiller, Peter W.; Tourwe, Dirk; Ballet, Steven

Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs

Discovery of Amphipathic Dynorphin A Analogues to Inhibit the Neuroexcitatory Effects of Dynorphin A through Bradykinin Receptors in the Spinal Cord

IF3

2015-03-01

OAAI

Mehr-un-Nisa; Munawar, A. Munawar; Lee, Yeon Sun; Rankin, David; Munir, Jawaria; Lai, Josephine; Khan, Misbahul A.; Hruby, Victor J.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2014-04-29

OAAI

Lee, Yeon Sun; Muthu, Dhanasekaran; Hall, Sara M.; Ramos-Colon, Cyf; Rankin, David; Hu, Jackie; Sandweiss, Alexander J.; De Felice, Milena; Xie, Jennifer Yanhua; Vanderah, Todd W.; Porreca, Frank; Lai, Josephine; Hruby, Victor J.

Chiral Effect of a Phe Residue in Position 3 of the Dmt1-L(or D)-Tic2 Analogues on Opioid Functional Activities

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2013-05-30

OAAI

Lee, Yeon Sun; Qu, HongChang; Davis, Peg; Ma, Shou-Wu; Vardanyan, Ruben; Lai, Josephine; Porreca, Frank; Hruby, Victor J.

Biological Active Analogues of the Opioid Peptide Biphalin: Mixed α/β3-Peptides

cis-4-Amino-L-proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2

IF6.8

2013-04-12

OAAI

Mollica, Adriano; Pinnen, Francesco; Costante, Roberto; Locatelli, Marcello; Stefanucci, Azzurra; Pieretti, Stefano; Davis, Peg; Lai, Josephine; Rankin, David; Porreca, Frank; Hruby, Victor J.

Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight

IF6.8

2012-09-25

PREAI

Mollica, Adriano; Pinnen, Francesco; Stefanucci, Azzurra; Mannina, Luisa; Sobolev, Anatoly P.; Lucente, Gino; Davis, Peg; Lai, Josephine; Ma, Shou-Wu; Porreca, Frank; Hruby, Victor J.

ENDOCRINOLOGY

IF3.3

2012-04-16

161

OAAI

Mittelman-Smith, Melinda A.; Williams, Hemalini; Krajewski-Hall, Sally J.; Lai, Josephine; Ciofi, Philippe; McMullen, Nathaniel T.; Rance, Naomi E.

The cis-4-Amino-L-proline Residue as a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E2 in the spinal cord

IF6.8

2012-03-22

OAAI

Mollica, Adriano; Pinnen, Francesco; Stefanucci, Azzurra; Feliciani, Federica; Campestre, Cristina; Mannina, Luisa; Sobolev, Anatoly P.; Lucente, Gino; Davis, Peg; Lai, Josephine; Ma, Shou-Wu; Porreca, Frank; Hruby, Victor J.

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

IF5.5

2012-01-01

OAAI

Marshall, Timothy M.; Herman, David S.; Largent-Milnes, Tally M.; Badghisi, Hamid; Zuber, Konstantina; Holt, Shannon C.; Lai, Josephine; Porreca, Frank; Vanderah, Todd W.

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

IF5.5

2011-12-01

190

OAAI

De Felice, Milena; Sanoja, Raul; Wang, Ruizhong; Vera-Portocarrero, Louis; Oyarzo, Janice; King, Tamara; Ossipov, Michael H.; Vanderah, Todd W.; Lai, Josephine; Dussor, Gregory O.; Fields, Howard L.; Price, Theodore J.; Porreca, Frank

Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

IF3

2011-10-01

OAAI

Vardanyan, Ruben; Kumirov, Vlad K.; Nichol, Gary S.; Davis, Peg; Liktor-Busa, Erika; Rankin, David; Varga, Eva; Vanderah, Todd; Porreca, Frank; Lai, Josephine; Hruby, Victor J.

Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy 前扣带回皮质的病变消除了部分或完全轴突切开术后自发性神经性疼痛的厌恶性

IF5.5

2011-09-01

OAAI

King, Tamara; Qu, Chaoling; Okun, Alec; Mercado, Ramon; Ren, Jiyang; Brion, Triza; Lai, Josephine; Porreca, Frank

Descending Facilitatory Pathways from the Rostroventromedial Medulla Mediate Naloxone-Precipitated Withdrawal in Morphine-Dependent Rats

IF5.5

2011-07-01

201

OAAI

Qu, Chaoling; King, Tamara; Okun, Alec; Lai, Josephine; Fields, Howard L.; Porreca, Frank

JOURNAL OF PAIN

IF4

2011-06-01

OAAI

Vera-Portocarrero, Louis P.; Ossipov, Michael H.; Lai, Josephine; King, Tamara; Porreca, Frank

Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist

Discovery of a Potent and Efficacious Peptide Derivative for δ/μ Opioid Agonist/Neurokinin 1 Antagonist Activity with a 2′,6′-Dimethyl-L-Tyrosine: In vitro, In vivo, and NMR-Based Structural Studies

IF6.8

2011-03-17

OAAI

Ballet, Steven; Feytens, Debby; Buysse, Koen; Chung, Nga N.; Lemieux, Carole; Tumati, Suneeta; Keresztes, Attila; Van Duppen, Joost; Lai, Josephine; Varga, Eva; Porreca, Frank; Schiller, Peter W.; Broeck, Jozef Vanden; Tourwe, Dirk