未登录 分享 收藏
分享 收藏
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor Johannes, Jeffrey W.; Balazs, Amber Y. S.; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, SebastienL.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin J.; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie J. B.; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Mcwilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andy; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan 分享 收藏
Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes Taylor, Jonathan D.; Barrett, Nathalie; Martinez Cuesta, Sergio; Cassidy, Katelyn; Pachl, Fiona; Dodgson, James; Patel, Radhika; Eriksson, Tuula M.; Riley, Aidan; Burrell, Matthew; Bauer, Christin; Rees, D. Gareth; Cimbro, Raffaello; Zhang, Andrew X.; Minter, Ralph R.; Hunt, James; Legg, Sandrine 分享 收藏
Late Breaking Abstract - Investigation of cKIT driven bone marrow toxicity and translation to human Larsson, Marie; Gill, Sonja; Pin, Carmen; Pachl, Fiona; Khan, Kainat; Cartwright, James; Macdonald, Ruth; Rose, Jonathan; Clayton, Benjamin; Leonard, Emilyanne; Hornberg, Jorrit; Ollerstam, Anna; Larner, Carrie 分享 收藏
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs Johannes, Jeffrey W.; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, Sebastien L.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan 分享 收藏
Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase 发现选择性降解IRAK3假激酶的蛋白水解靶向嵌合体分子 Degorce, Sebastien L.; Tavana, Omid; Banks, Erica; Crafter, Claire; Gingipalli, Lakshmaiah; Kouvchinov, David; Mao, Yumeng; Pachl, Fiona; Solanki, Anisha; Valge-Archer, Viia; Yang, Bin; Edmondson, Scott D. 分享 收藏
分享 收藏
分享 收藏
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex EED靶向的protac降解PRC2复合物中的EED，EZH2和SUZ12 Hsu, Jessie Hao-Ru; Rasmusson, Timothy; Robinson, James; Pachl, Fiona; Read, Jon; Kawatkar, Sameer; O'Donovan, Daniel H.; Bagal, Sharan; Code, Erin; Rawlins, Philip; Argyrou, Argyrides; Tomlinson, Ronald; Gao, Ning; Zhu, Xiahui; Chiarparin, Elisabetta; Jacques, Kelly; Shen, Minhui; Woods, Haley; Bednarski, Emma; Wilson, David M.; Drew, Lisa; Castaldi, M. Paola; Fawell, Stephen; Bloecher, Andrew 分享 收藏
EED targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex Hsu, Jessie Hao-Ru; Rasmusson, Timothy; Robinson, James; Pachl, Fiona; Read, Jon; Kawatkar, Sameer; O'Donovan, Daniel H.; Bagal, Sharan; Code, Erin; Rawlins, Philip; Argyrou, Argyrides; Tomlinson, Ronald; Gao, Ning; Zhu, Xiahui; Chiarparin, Elisabetta; Jacques, Kelly; Shen, Minhui; Woods, Haley; Bednarski, Emma; Wilson, David M.; Drew, Lisa; Castaldi, M. Paola; Fawell, Stephen; Bloecher, Andrew 分享 收藏
A head-to-head comparison of the properties of five clinical PARP inhibitors identifies new insights that can explain both the observed clinical efficacy and safety profiles Leo, Elisabetta; Johannes, Jeffrey; Illuzzi, Giuditta; Zhang, Andrew; Hemsley, Paul; Bista, Michal J.; Orme, Jonathan P.; Talbot, Verity A.; Narvaez, Ana J.; Underwood, Elizabeth; Pike, Andrew; Nikkila, Jenni K.; Riches, Lucy; Sweeney, Sinbad; Gustafsson, Frida; Cronin, Anna; Ricchiuto, Piero; Roaquin, Debora A.; Pachl, Fiona; Miele, Eric; MacDonald, Ruth; Hawthorne, Glen; Mead, Andrew N.; O'Connor, Mark J. 分享 收藏
Towards Understanding Male Infertility After Spinal Cord Injury Using Quantitative Proteomics da Silva, Barbara Ferreira; Meng, Chen; Helm, Dominic; Pachl, Fiona; Schiller, Jurgen; Ibrahim, Emad; Lynne, Charles M.; Brackett, Nancy L.; Bertolla, Ricardo Pimenta; Kuster, Bernhard 分享 收藏
分享 收藏
Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling 用于激酶抑制剂分析的优化化学蛋白质组学分析 Medard, Guillaume; Pachl, Fiona; Ruprecht, Benjamin; Klaeger, Susan; Heinzlmeir, Stephanie; Helm, Dominic; Qiao, Huichao; Ku, Xin; Wilhelm, Mathias; Kuehne, Thomas; Wu, Zhixiang; Dittmann, Antje; Hopf, Carsten; Kramer, Karl; Kuster, Bernhard 分享 收藏
分享 收藏
Ion Mobility Tandem Mass Spectrometry Enhances Performance of Bottom-up Proteomics Helm, Dominic; Vissers, Johannes P. C.; Hughes, Christopher J.; Hahne, Hannes; Ruprecht, Benjamin; Pachl, Fiona; Grzyb, Arkadiusz; Richardson, Keith; Wildgoose, Jason; Maier, Stefan K.; Marx, Harald; Wilhelm, Mathias; Becher, Isabelle; Lemeer, Simone; Bantscheff, Marcus; Langridge, James I.; Kuster, Bernhard 分享 收藏
Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1 Raab, Monika; Kraemer, Andrea; Hehlgans, Stephanie; Sanhaji, Mouraol; Kurunci-Csacsko, Elisabeth; Doetsch, Christina; Bug, Gesine; Ottmann, Oliver; Becker, Sven; Pachl, Fiona; Kuster, Bernhard; Strebhardt, Klaus 分享 收藏
分享 收藏
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments Hahne, Hannes; Pachl, Fiona; Ruprecht, Benjamin; Maier, Stefan K.; Klaeger, Susan; Helm, Dominic; Medard, Guillaume; Wilm, Matthias; Lemeer, Simone; Kuster, Bernhard 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
