未登录 2-aminobenzophenones as a novel class of bradykinin B1 receptor antagonists Su, Dai-Shi; Lim, John L.; Tinney, Elizabeth; Wan, Bang-Lin; Murphy, Kathy L.; Reiss, Duane R.; Harrell, C. Meacham; O'Malley, Stacy S.; Ransom, Rick W.; Chang, Raymond S. L.; Pettibone, Douglas J.; Yu, Jian; Tang, Cuyue; Prueksaritanont, Thomayant; Freidinger, Roger M.; Bock, Mark G.; Anthony, Neville J. 分享 收藏
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1(propylsulfonyl)piperidin-4-yl]lmethyl benzamides Lindsley, Craig W.; Zhao, Zhijian; Leister, William H.; O'Brien, Julie; Lemaire, Wei; Williams, David L., Jr.; Chen, Tsing-Bau; Chang, Raymond S. L.; Burno, Maryann; Jacobson, Marlene A.; Sur, Cyrille; Kinney, Gene G.; Pettibone, Douglas J.; Tiller, Philip R.; Smith, Sheri; Tsou, Nancy N.; Duggan, Mark E.; Conn, P. Jeffrey; Hartman, George D. 分享 收藏
Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine.: Application to the design of novel bradykinin B1 receptor antagonists Wood, MR; Schirripa, KM; Kim, JJ; Wan, BL; Murphy, KL; Ransom, RW; Chang, RSL; Tang, CY; Prueksaritanont, T; Detwiler, TJ; Hettrick, LA; Landis, ER; Leonard, YM; Krueger, JA; Lewis, SD; Pettibone, DJ; Freidinger, RM; Bock, MG 分享 收藏
Difference in mGluR5 interaction between positive allosteric modulators from two structural classes 来自两个结构课程的正变构调节剂之间mGluR5相互作用的差异 Williams, DL; O'Brien, JA; Lemaire, W; Chen, TB; Chang, RSL; Jacobson, MA; Ha, SN; Wisnoski, DD; Lindsley, CW; Sur, C; Duggan, ME; Pettibone, DJ; Conn, PJ 分享 收藏
2,3-diaminopyridine bradykinin B1 receptor antagonists Kuduk, SD; Ng, C; Feng, DM; Wai, JMC; Chang, RSL; Harrell, CM; Murphy, KL; Ransom, RW; Reiss, D; Ivarsson, M; Mason, G; Boyce, S; Tang, CY; Prueksaritanont, T; Freidinger, RM; Pettibone, DJ; Bock, MG 分享 收藏
Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist Ransom, RW; Harrell, CM; Reiss, DR; Murphy, KL; Chang, RSL; Hess, JF; Miller, PJ; O'Malley, SS; Hey, PJ; Kunapuli, P; Su, DS; Markowitz, MK; Wallace, MA; Raab, CE; Jones, AN; Dean, DC; Pettibone, DJ; Freidinger, RM; Bock, MG 分享 收藏
Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model Hess, JF; Ransom, RW; Zeng, ZZ; Chang, RSL; Hey, PJ; Warren, L; Harrell, CM; Murphy, KL; Chen, TB; Miller, PJ; Lis, E; Reiss, D; Gibson, RE; Markowitz, MK; DiPardo, RM; Su, DS; Bock, MG; Gould, RJ; Pettibone, DJ 分享 收藏
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 O'Brien, JA; Lemaire, W; Chen, TB; Chang, RSL; Jacobson, MA; Ha, SN; Lindsley, CW; Schaffhauser, HJ; Sur, C; Pettibone, DJ; Conn, PJ; Williams, DL 分享 收藏
Discovery of a potent, non-peptide bradykinin B1 receptor antagonist Su, DS; Markowitz, MK; DiPardo, RM; Murphy, KL; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RSL; Ha, S; Hess, FJ; Pettibone, DJ; Mason, GS; Boyce, S; Freidinger, RM; Bock, MG 分享 收藏
Benzodiazepines as potent and selective bradykinin B1 antagonists Wood, MR; Kim, JJ; Han, W; Dorsey, BD; Homnick, CF; DiPardo, RM; Kuduk, SD; MacNeil, T; Murphy, KL; Lis, EV; Ransom, RW; Stump, GL; Lynch, JJ; O'Malley, SS; Miller, PJ; Chen, TB; Harrell, CM; Chang, RSL; Sandhu, P; Ellis, JD; Bondiskey, PJ; Pettibone, DJ; Freidinger, RM; Bock, MG 分享 收藏
NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .1. DESIGN, SYNTHESIS, AND BIOLOGICAL-ACTIVITY OF N-SUBSTITUTED INDOLES AND DIHYDROINDOLES DHANOA, DS; BAGLEY, SW; CHANG, RSL; LOTTI, VJ; CHEN, TB; KIVLIGHN, SD; ZINGARO, GJ; SIEGL, PKS; PATCHETT, AA; GREENLEE, WJ 分享 收藏
A HIGHLY POTENT, ORALLY-ACTIVE IMIDAZO[4,5-B]PYRIDINE BIPHENYLACYLSULFONAMIDE (MK-996-L-159,282) - A NEW ANGIOTENSIN-II RECEPTOR ANTAGONIST CHAKRAVARTY, PK; NAYLOR, EM; CHEN, A; CHANG, RSL; CHEN, TB; FAUST, KA; LOTTI, VJ; KIVLIGHN, SD; GABLE, RA; ZINGARO, GJ; SCHORN, TW; SCHAFFER, LW; BROTEN, TP; SIEGL, PKS; PATCHETT, AA; GREENLEE, WJ 分享 收藏
NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .2. DESIGN, SYNTHESIS, AND BIOLOGICAL-ACTIVITY OF N-SUBSTITUTED (PHENYLAMINO)PHENYLACETIC ACIDS AND ACYL SULFONAMIDES DHANOA, DS; BAGLEY, SW; CHANG, RSL; LOTTI, VJ; CHEN, TB; KIVLIGHN, SD; ZINGARO, GJ; SIEGL, PKS; PATCHETT, AA; GREENLEE, WJ 分享 收藏
In vitro studies on L-771,688 (SNAP 6383), a new potent and selective α1A-adrenoceptor antagonist Chang, RSL; Chen, TB; O'Malley, SS; Pettibone, DJ; DiSalvo, J; Francis, B; Bock, MG; Freidinger, R; Nagarathnam, D; Miao, SW; Shen, QR; Lagu, B; Dhar, TGM; Tyagarajan, S; Marzabadi, MR; Wong, WC; Gluchowski, C; Forray, C 分享 收藏
In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective α1A receptor antagonists for the treatment of benign prostatic hyperplasia Barrow, JC; Nantermet, PG; Selnick, HG; Glass, KL; Rittle, KE; Gilbert, KF; Steele, TG; Homnick, CF; Freidinger, RM; Ransom, RW; Kling, P; Reiss, D; Broten, TP; Schorn, TW; Chang, RSL; O'Malley, SS; Olah, TV; Ellis, JD; Barrish, A; Kassahun, K; Leppert, P; Nagarathnam, D; Forray, C 分享 收藏
De novo design of a novel oxazolidinone analogue as a potent and selective α1A adrenergic receptor antagonist with high oral bioavailability Lagu, B; Tian, D; Jeon, Y; Li, C; Wetzel, JM; Nagarathnam, D; Shen, QR; Forray, C; Chang, RSL; Broten, TP; Ransom, RW; Chan, TB; O'Malley, SS; Schorn, TW; Rodrigues, AD; Kassahun, K; Pettibone, DJ; Freidinger, R; Gluchowski, C 分享 收藏
Design and synthesis of novel α1a adrenoceptor-selective antagonists.: 2.: Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety Dhar, TGM; Nagarathnam, D; Marzabadi, MR; Lagu, B; Wong, WC; Chiu, G; Tyagarajan, S; Miao, SW; Zhang, FQ; Sun, WY; Tian, D; Shen, QR; Zhang, J; Wetzel, JM; Forray, C; Chang, RSL; Broten, TP; Schorn, TW; Chen, TB; O'Malley, S; Ransom, R; Schneck, K; Bendesky, R; Harrell, CM; Vyas, KP; Zhang, KY; Gilbert, J; Pettibone, DJ; Patane, MA; Bock, MG; Freidinger, RM; Gluchowski, C 分享 收藏
Design and synthesis of novel α1a adrenoceptor-selective antagonists.: 3.: Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains Lagu, B; Tian, D; Nagarathnam, D; Marzabadi, MR; Wong, WC; Miao, SW; Zhang, FQ; Sun, WY; Chiu, G; Fang, J; Forray, C; Chang, RSL; Ransom, RW; Chen, TB; O'Malley, S; Zhang, KY; Vyas, KP; Gluchowski, C 分享 收藏
Design and synthesis of novel α1a adrenoceptor-selective antagonists.: 1.: Structure-activity relationship in dihydropyrimidinones Nagarathnam, D; Miao, SW; Lagu, B; Chiu, G; Fang, J; Dhar, TGM; Zhang, J; Tyagarajan, S; Marzabadi, MR; Zhang, FQ; Wong, WC; Sun, WY; Tian, D; Wetzel, JM; Forray, C; Chang, RSL; Broten, TP; Ransom, RW; Schorn, TW; Chen, TB; O'Malley, S; Kling, P; Schneck, K; Bendesky, R; Harrell, CM; Vyas, KP; Gluchowski, C 分享 收藏
Design and synthesis of novel α1a adrenoceptor-selective antagonists.: 4.: Structure-activity relationship in the dihydropyrimidine series Wong, WC; Sun, WY; Lagu, B; Tian, D; Marzabadi, MR; Zhang, FQ; Nagarathnam, D; Miao, SW; Wetzel, JM; Peng, J; Forray, C; Chang, RSL; Chen, TB; Ransom, R; O'Malley, S; Broten, TP; Kling, P; Vyas, KP; Zhang, KY; Gluchowski, C 分享 收藏
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