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Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing 快速两步目标捕获确保高效的CRISPR-Cas9引导的基因组编辑 Shi, Honglue; Al-Sayyad, Noor; Wasko, Kevin M.; Trinidad, Marena I.; Doherty, Erin E.; Vohra, Kamakshi; Boger, Ron S.; Colognori, David; Cofsky, Joshua C.; Skopintsev, Petr; Bryant, Zev; Doudna, Jennifer A. 分享 收藏
Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra 阿尔茨海默病中选择性神经元易损性的通路：对比易损的蓝斑核与有抵抗力的黑质 Ehrenberg, AJ; Sant, C; Pereira, FL; Li, SH; Buxton, J; Langlois, S; Trinidad, M; Oh, I; Leite, REP; Rodriguez, RD; Paes, VR; Pasqualucci, CA; Seeley, WW; Spina, S; Suemoto, CK; Temple, S; Kaufer, D; Grinberg, LT 分享 收藏
RNA language models predict mutations that improve RNA function Shulgina, Yekaterina; Trinidad, Marena I.; Langeberg, Conner J.; Nisonoff, Hunter; Chithrananda, Seyone; Skopintsev, Petr; Nissley, Amos J.; Patel, Jaymin; Boger, Ron S.; Shi, Honglue; Yoon, Peter H.; Doherty, Erin E.; Pande, Tara; Iyer, Aditya M.; Doudna, Jennifer A.; Cate, Jamie H. D. 分享 收藏
Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein 通过脂质纳米颗粒递送稳定的CRISPR-Cas9核糖核蛋白进行肺和肝编辑 Chen, Kai; Han, Hesong; Zhao, Sheng; Xu, Bryant; Yin, Boyan; Lawanprasert, Atip; Trinidad, Marena; Burgstone, Benjamin W.; Murthy, Niren; Doudna, Jennifer A. 分享 收藏
Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants Silva, Dina Buitrago; Trinidad, Marena; Ljungdahl, Alicia; Revalde, Jezrael L.; Berguig, Geoffrey Y.; Wallace, William; Patrick, Cory S.; Bomba, Lorenzo; Arkin, Michelle; Dong, Shan; Estrada, Karol; Hutchinson, Keino; Lebowitz, Jonathan H.; Schlessinger, Avner; Johannesen, Katrine M.; Moller, Rikke S.; Giacomini, Kathleen M.; Froelich, Steven; Sanders, Stephan J.; Wuster, Arthur 分享 收藏
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Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes 真核RNA引导的核酸内切酶是从细菌酶的独特进化枝进化而来的 Yoon, Peter H.; Skopintsev, Petr; Shi, Honglue; Chen, LinXing; Adler, Benjamin A.; Al-Shimary, Muntathar; Craig, Rory J.; Loi, Kenneth J.; DeTurk, Evan C.; Li, Zheng; Amerasekera, Jasmine; Trinidad, Marena; Nisonoff, Hunter; Chen, Kai; Lahiri, Arushi; Boger, Ron; Jacobsen, Steve; Banfield, Jillian F.; Doudna, Jennifer A. 分享 收藏
CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes CasPEDIA数据库: 2类crispr-cas酶的功能分类系统 Adler, Benjamin A.; Trinidad, Marena, I; Bellieny-Rabelo, Daniel; Zhang, Elaine; Karp, Hannah M.; Skopintsev, Petr; Thornton, Brittney W.; Weissman, Rachel F.; Yoon, Peter H.; Chen, Linxing; Hessler, Tomas; Eggers, Amy R.; Colognori, David; Boger, Ron; Doherty, Erin E.; Tsuchida, Connor A.; Tran, Ryan, V; Hofman, Laura; Shi, Honglue; Wasko, Kevin M.; Zhou, Zehan; Xia, Chenglong; Al-Shimary, Muntathar J.; Patel, Jaymin R.; Thomas, Vienna C. J. X.; Pattali, Rithu; Kan, Matthew J.; Vardapetyan, Anna; Yang, Alana; Lahiri, Arushi; Maxwell, Michaela F.; Murdock, Andrew G.; Ramit, Glenn C.; Henderson, Hope R.; Calvert, Roland W.; Bamert, Rebecca S.; Knott, Gavin J.; Lapinaite, Audrone; Pausch, Patrick; Cofsky, Joshua C.; Sontheimer, Erik J.; Wiedenheft, Blake; Fineran, Peter C.; Brouns, Stan J. J.; Sashital, Dipali G.; Thomas, Brian C.; Brown, Christopher T.; Goltsman, Daniela S. A.; Barrangou, Rodolphe; Siksnys, Virginius; Banfield, Jillian F.; Savage, David F.; Doudna, Jennifer A. 分享 收藏
SLC6A1 variant pathogenicity, molecular function and phenotype: a genetic and clinical analysis SLC6A1变异致病性、分子功能和表型: 遗传和临床分析 Stefanski, Arthur; Perez-Palma, Eduardo; Bruenger, Tobias; Montanucci, Ludovica; Gati, Cornelius; Kloeckner, Chiara; Johannesen, Katrine M.; Goodspeed, Kimberly; Macnee, Marie; Deng, Alexander T.; Aledo-Serrano, Angel; Borovikov, Artem; Kava, Maina; Bouman, Arjan M.; Hajianpour, M. J.; Pal, Deb K.; Engelen, Marc; Hagebeuk, Eveline E. O.; Shinawi, Marwan; Heidlebaugh, Alexis R.; Oetjens, Kathryn; Hoffman, Trevor L.; Striano, Pasquale; Freed, Amanda S.; Futtrup, Line; Balslev, Thomas; Abuli, Anna; Danvoye, Leslie; Lederer, Damien; Balci, Tugce; Nouri, Maryam Nabavi; Butler, Elizabeth; Drewes, Sarah; van Engelen, Kalene; Howell, Katherine B.; Khoury, Jean; May, Patrick; Trinidad, Marena; Froelich, Steven; Lemke, Johannes R.; Tiller, Jacob; Freed, Amber N.; Kang, Jing-Qiong; Wuster, Arthur; Moller, Rikke S.; Lal, Dennis 分享 收藏
Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs Stahl, Elizabeth C.; Sabo, Jennifer K.; Kang, Min Hyung; Allen, Ryan; Applegate, Elizabeth; Kim, Shin Eui; Kwon, Yoonjin; Seth, Anmol; Lemus, Nicholas; Salinas-Rios, Viviana; Soczek, Katarzyna M.; Trinidad, Marena; Vo, Linda T.; Jeans, Chris; Wozniak, Anna; Morris, Timothy; Kimberlin, Athen; Foti, Thomas; Savage, David F.; Doudna, Jennifer A. 分享 收藏
Predicting disease severity in metachromatic leukodystrophy using protein activity and a patient phenotype matrix Trinidad, Marena; Hong, Xinying; Froelich, Steven; Daiker, Jessica; Sacco, James; Nguyen, Hong Phuc; Campagna, Madelynn; Suhr, Dean; Suhr, Teryn; LeBowitz, Jonathan H.; Gelb, Michael H.; Clark, Wyatt T. 分享 收藏
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Improved genome editing by an engineered CRISPR-Cas12a Ma, Enbo; Chen, Kai; Shi, Honglue; Stahl, Elizabeth C.; Adler, Ben; Trinidad, Marena; Liu, Junjie; Zhou, Kaihong; Ye, Jinjuan; Doudna, Jennifer A. 分享 收藏
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Identifying therapeutic drug targets using bidirectional effect genes Estrada, Karol; Froelich, Steven; Wuster, Arthur; Bauer, Christopher R.; Sterling, Teague; Clark, Wyatt T.; Ru, Yuanbin; Trinidad, Marena; Hong Phuc Nguyen; Luu, Amanda R.; Wendt, Daniel J.; Yogalingam, Gouri; Yu, Guoying Karen; LeBowitz, Jonathan H.; Cardon, Lon R. 分享 收藏
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