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I

Ivan King

Sarah Cannon Research Institute
H指数:20
被引数:2,050

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Phase 1 study of zavondemstat (TACH101), a first-in-class KDM4 inhibitor, in patients with advanced solid tumors

I期研究：评估Zavondemstat（TACH101），一种首创KDM4抑制剂的疗效，用于治疗晚期实体瘤患者

ONCOLOGIST
IF4.2
2025-07-010
OAAI
Tsimberidou, Apostolia M.; Dayyani, Farshid; Sommerhalder, David; Vandross, Andrae L.; Pelster, Meredith S.; Henry, Jason T.; Perez, Cesar A.; Chakraborty, Abhijit; Baysal, Mehmet A.; Chandhasin, Chandtip; Dai, Yiyun; Tu, Shirley; King, Ivan; Perabo, Frank
Inhibitors of farnesyl protein transferase.: 4-amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
1998-02-1934
PREAI
Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, SY; Nomeir, AA; Lin, CC; Li, ZJ; Chen, JP; Lee, S; Dell, J; Lipari, P; Malkowski, M; Yaremko, B; King, I; Liu, M
Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine inhibitors of farnesyl-protein transferase:: Design and synthesis of in vivo active antitumor compounds
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
1997-12-1958
PREAI
Njoroge, FG; Vibulbhan, B; Rane, DF; Bishop, WR; Petrin, J; Patton, R; Bryant, MS; Chen, KJ; Nomeir, AA; Lin, CC; Liu, M; King, I; Chen, JP; Lee, SN; Yaremko, B; Dell, J; Lipari, P; Malkowski, M; Li, ZJ; Catino, J; Doll, RJ; Girijavallabhan, V; Ganguly, AK

研究方向

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D
David Bermudes
H 指数:34论文数:88被引数:5,841
R
Robert Patton
H 指数:26论文数:190被引数:2,741
M
Michael G. Malkowski
H 指数:37论文数:119被引数:4,748
S
Stanley L. Lin
H 指数:31论文数:69被引数:2,786
A
Amin A. Nomeir
H 指数:34论文数:165被引数:4,660
F
Frank Perabo
H 指数:26论文数:120被引数:5,000
L
Li-Mou Zheng
H 指数:15论文数:38被引数:1,560
W
W. Robert Bishop
H 指数:43论文数:155被引数:8,829
Z
Zujun Li
H 指数:15论文数:101被引数:794
A
Ashit K. Ganguly
H 指数:30论文数:134被引数:2,881