未登录Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site天然 (二氢) 菲植物化合物通过其变构药物和代谢物结合位点是AMPK的直接激活剂
Sanders, Matthew J.; Ratinaud, Yann; Neopane, Katyayanee; Bonhoure, Nicolas; Day, Emily A.; Ciclet, Olivier; Lassueur, Steve; Pinta, Martine Naranjo; Deak, Maria; Brinon, Benjamin; Christen, Stefan; Steinberg, Gregory R.; Barron, Denis; Sakamoto, Kei .png)
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收藏AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTORAMPK通过独立于mTOR激活TFEB促进肿瘤抑制因子FLCN的诱导Collodet, Caterina; Foretz, Marc; Deak, Maria; Bultot, Laurent; Metairon, Sylviane; Viollet, Benoit; Lefebvre, Gregory; Raymond, Frederic; Parisi, Alice; Civiletto, Gabriele; Gut, Philipp; Descombes, Patrick; Sakamoto, Kei 分享 收藏 分享 收藏 Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates化学遗传筛选将Gapex-5/GAPVDI和STBD1鉴定为新的AMPK底物Ducommun, Serge; Deak, Maria; Zeigerer, Anja; Goransson, Olga; Seitz, Susanne; Collodet, Caterina; Madsen, Agnete B.; Jensen, Thomas E.; Viollet, Benoit; Foretz, Marc; Gut, Philipp; Sumpton, David; Sakamoto, Kei 分享 收藏 Standardized LCxLC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural ExtractsCoulerie, Paul; Ratinaud, Yann; Moco, Sofia; Merminod, Loraine; Pinta, Martine Naranjo; Boccard, Julien; Bultot, Laurent; Deak, Maria; Sakamoto, Kei; Queiroz, Emerson Ferreira; Wolfender, Jean-Luc; Barron, Denis 分享 收藏 分享 收藏 Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate用于发现细胞AMPK靶标的基序亲和和质谱蛋白质组学方法: 鉴定线粒体裂变因子作为新的AMPK底物Ducommun, Serge; Deak, Maria; Sumpton, David; Ford, Rebecca J.; Galindo, Antonio Nunez; Kussmann, Martin; Viollet, Benoit; Steinberg, Gregory R.; Foretz, Marc; Dayon, Loic; Morrice, Nicholas A.; Sakamoto, Kei 分享 收藏 The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liverPatel, Kashyap; Foretz, Marc; Marion, Allison; Campbell, David G.; Gourlay, Robert; Boudaba, Nadia; Tournier, Emilie; Titchenell, Paul; Peggie, Mark; Deak, Maria; Wan, Min; Kaestner, Klaus H.; Goransson, Olga; Viollet, Benoit; Gray, Nathanael S.; Birnbaum, Morris J.; Sutherland, Calum; Sakamoto, Kei 分享 收藏 Structural basis for the recruitment of glycogen synthase by glycogeninZeqiraj, Elton; Tang, Xiaojing; Hunter, Roger W.; Garcia-Rocha, Mar; Judd, Andrew; Deak, Maria; von Wilamowitz-Moellendorff, Alexander; Kurinov, Igor; Guinovart, Joan J.; Tyers, Mike; Sakamoto, Kei; Sicheri, Frank 分享 收藏 分享 收藏 分享 收藏 Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicityYao, Chen; Johnson, William M.; Gao, Yue; Wang, Wen; Zhang, Jinwei; Deak, Maria; Alessi, Dario R.; Zhu, Xiongwei; Mieyal, John J.; Roder, Hanno; Wilson-Delfosse, Amy L.; Chen, Shu G. 分享 收藏 分享 收藏 TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and developmentBouskila, Michale; Esoof, Noor; Gay, Laurie; Fang, Emily H.; Deak, Maria; Begley, Michael J.; Cantley, Lewis C.; Prescott, Alan; Storey, Kate G.; Alessi, Dario R. 分享 收藏 MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesMO25是SPAK/OSR1和MST3/MST4/YSK1蛋白激酶的主要调节剂Filippi, Beatrice M.; de los Heros, Paola; Mehellou, Youcef; Navratilova, Iva; Gourlay, Robert; Deak, Maria; Plater, Lorna; Toth, Rachel; Zeqiraj, Elton; Alessi, Dario R. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationNichols, R. Jeremy; Dzamko, Nicolas; Morrice, Nicholas A.; Campbell, David G.; Deak, Maria; Ordureau, Alban; Macartney, Thomas; Tong, Youren; Shen, Jie; Prescott, Alan R.; Alessi, Dario R. 分享 收藏 
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