未登录Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation由细胞外三磷酸腺苷激活的CD137抗体具有肿瘤选择性，在体内广泛有效，无需全身免疫激活
Kamata-Sakurai, Mika; Narita, Yoshinori; Hori, Yuji; Nemoto, Takayuki; Uchikawa, Ryo; Honda, Masaki; Hironiwa, Naoka; Taniguchi, Kenji; Shida-Kawazoe, Meiri; Metsugi, Shoichi; Miyazaki, Taro; Wada, Naoko A.; Ohte, Yuki; Shimizu, Shun; Mikami, Hirofumi; Tachibana, Tatsuhiko; Ono, Natsuki; Adachi, Kenji; Sakiyama, Tetsushi; Matsushita, Tomochika; Kadono, Shojiro; Komatsu, Shun-ichiro; Sakamoto, Akihisa; Horikawa, Sayuri; Hirako, Ayano; Hamada, Koki; Naoi, Sotaro; Savory, Nasa; Satoh, Yasuko; Sato, Motohiko; Noguchi, Yuki; Shinozuka, Junko; Kuroi, Haruka; Ito, Ami; Wakabayashi, Tetsuya; Kamimura, Masaki; Isomura, Fumihisa; Tomii, Yasushi; Sawada, Noriaki; Kato, Atsuhiko; Ueda, Otoya; Nakanishi, Yoshito; Endo, Mika; Jishage, Kou-ichi; Kawabe, Yoshikii; Kitazawa, Takehisa; Igawa, Tomoyuki .png)
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收藏YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene AmplificationHamanaka, Natsuki; Nakanishi, Yoshito; Mizuno, Takakazu; Horiguchi-Takei, Kana; Akiyama, Nukinori; Tanimura, Hiromi; Hasegawa, Masami; Satoh, Yasuko; Tachibana, Yukako; Fujii, Toshihiko; Sakata, Kiyoaki; Ogasawara, Kiyomoto; Ebiike, Hirosato; Koyano, Hiroshi; Sato, Haruhiko; Ishii, Nobuya; Mio, Toshiyuki 分享 收藏 Acquired JHDM1D-BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2-Amplified Gastric CancerSase, Hitoshi; Nakanishi, Yoshito; Aida, Satoshi; Horiguchi-Takei, Kana; Akiyama, Nukinori; Fujii, Toshihiko; Sakata, Kiyoaki; Mio, Toshiyuki; Aoki, Masahiro; Ishii, Nobuya 分享 收藏 Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) InhibitorEbiike, Hirosato; Taka, Naoki; Matsushita, Masayuki; Ohmori, Masayuki; Takami, Kyoko; Hyohdoh, Ikumi; Kohchi, Masami; Hayase, Tadakatsu; Nishii, Hiroki; Morikami, Kenji; Nakanishi, Yoshito; Akiyama, Nukinori; Shindoh, Hidetoshi; Ishii, Nobuya; Isobe, Takehito; Matsuoka, Hiroharu 分享 收藏 ERK signal suppression and sensitivity to CH5183284/Debio 1347, a selective FGFR inhibitorNakanishi, Yoshito; Mizuno, Hideaki; Sase, Hitoshi; Fujii, Toshihiko; Sakata, Kiyoaki; Akiyama, Nukinori; Aoki, Yuko; Aoki, Masahiro; Ishii, Nobuya 分享 收藏 分享 收藏 ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR InhibitorNakanishi, Yoshito; Mizuno, Hideaki; Sase, Hitoshi; Fujii, Toshihiko; Sakata, Kiyoaki; Akiyama, Nukinori; Aoki, Yuko; Aoki, Masahiro; Ishii, Nobuya 分享 收藏 分享 收藏 Pharmacodynamic biomarker evaluation in phase I clinical trials of selective PI3K and PI3K/mTOR inhibitorsNakanishi, Yoshito; Spoerke, Jill M.; Derynck, Mika; Lauchle, Jennifer O.; Koeppen, Hartmut; Fredrickson, Jill; Ware, Joseph; Hampton, Garret; Yan, Yibing; Lackner, Mark R. 分享 收藏 分享 收藏 The Fibroblast Growth Factor Receptor Genetic Status as a Potential Predictor of the Sensitivity to CH5183284/Debio 1347, a Novel Selective FGFR InhibitorNakanishi, Yoshito; Akiyama, Nukinori; Tsukaguchi, Toshiyuki; Fujii, Toshihiko; Sakata, Kiyoaki; Sase, Hitoshi; Isobe, Takehito; Morikami, Kenji; Shindoh, Hidetoshi; Mio, Toshiyuki; Ebiike, Hirosato; Taka, Naoki; Aoki, Yuko; Ishii, Nobuya 分享 收藏 Design and preclinical profile of CH5183284/Debio 1347, a novel orally available and selective FGFR inhibitor acting on a gatekeeper mutant of FGFR2Ebiike, Hirosato; Taka, Naoki; Nakanishi, Yoshito; Akiyama, Nukinori; Sawamura, Fumie; Morikami, Kenji; Matsushita, Masayuki; Ohmori, Masayuki; Takami, Kyouko; Hyohdoh, Ikumi; Kohchi, Masami; Hayase, Tadakatsu; Nishii, Hiroki; Ishii, Nobuya; Matsuoka, Hiroharu 分享 收藏 FGFR genetic alterations as a potential predictor of the sensitivity to CH5183284/Debio 1347, a selective FGFR inhibitor with a novel chemical scaffoldNakanishi, Yoshito; Akiyama, Nukinori; Tsukaguchi, Toshiyuki; Tachibana-Kondo, Yukako; Fujii, Toshihiko; Sakata, Kiyoaki; Sase, Hitoshi; Isobe, Takehito; Sato, Yasuko; Morikami, Kenji; Shindoh, Hidetoshi; Mio, Toshiyuki; Ebiike, Hirosato; Taka, Naoki; Aoki, Yuko; Ishii, Nobuya 分享 收藏 Inhibition of FGFR3-BAIAP2L1 fusion kinase oncogenic potential by CH5183284/Debio 1347, a compound that inhibits FGFR3 kinase activity constitutively activated by BAIAP2L1 BAR domain dimerizationAkiyama, Nukinori; Nakanishi, Yoshito; Tsukaguchi, Toshiyuki; Satoh, Yasuko; Nagata, Yasue; Takahashi, Tsutomu; Nishito, Yukari; Ashihara, Motoki; Ishii, Nobuya; Aoki, Masahiro 分享 收藏 Pre-clinical investigation of predictive biomarkers for drug candidates using a molecularly profiled large cancer cell line panel.Aida, Satoshi; Mizuno, Hideaki; Sakamoto, Hiroshi; Nakanishi, Yoshito; Mutoh, Hironori; Cai, James; Burtscher, Helmut; Aoki, Masahiro; Aoki, Yuko; Ishii, Nobuya 分享 收藏 Targeting microtubule-associated protein 4 with novel small molecule CH4938056 confers antitumor activity under quasi in vivo conditions and in xenograft modelsKondoh, Osamu; Saito, Hidemi; Nakanishi, Yoshito; Tsukaguchi, Toshiyuki; Nagano, Kohji; Inomata, Noriyuki; Sakata, Kiyoaki; Fujii, Toshihiko; Satoh, Yasuko; Hattori, Kazuo; Niizuma, Satoshi; Koyama, Kohei; Okada, Takehiro; Minoshima, Yukinori; Kawashima, Toshiyuki; Kitamura, Toshio; Tsukuda, Takuo; Nobuo, Shimma; Arisawa, Mikio; Ishii, Nobuya; Aoki, Yuko 分享 收藏 分享 收藏 
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