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IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control IL-27 诱导一种细胞毒性CD8+ T细胞程序以强化肿瘤控制 Breart, Beatrice; Williams, Katherine; Krimm, Stellanie; Wong, Tiffany; Kayser, Brandon D.; Wang, Lifen; Cheng, Eric; Tleugabulova, Mayra Cruz; Bouziat, Romain; Lu, Tianshi; Yuen, Kobe; Firmino, Natalie S.; Bravo, Daniel D.; Roels, Juliette; Bhakta, Atish; Bevers, Jack; Lehoux, Isabelle; Gutierrez, Alan; Chestnut, Yajun; Klementowicz, Joanna E.; Arenzana, Teresita L.; Akhmetzyanova, Ilseyar; Dixon, Elizabeth; Chen, Min; Tasneem, Kazi; Yadav, Rajbharan; Koeppen, Hartmut; Oh, Soyoung A.; Delamarre, Lelia; Huang, Haochu; Lim, Shion A.; Nakamura, Gerald; Wang, Jianyong; Gao, Chan; Corpuz, Racquel; Mueller, Soeren; West, Nathaniel R. 分享 收藏
Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy Li, Xiao; Eastham, Jeffrey; Giltnane, Jennifer M.; Zou, Wei; Zijlstra, Andries; Tabatsky, Evgeniy; Banchereau, Romain; Chang, Ching-Wei; Nabet, Barzin Y.; Patil, Namrata S.; Molinero, Luciana; Chui, Steve; Harryman, Maureen; Lau, Shari; Rangell, Linda; Waumans, Yannick; Kockx, Mark; Orlova, Darya; Koeppen, Hartmut 分享 收藏
Digital pathology based prognostic & predictive biomarkers in metastatic non-small cell lung cancer Qamra, Aditi; Srivastava, Minu K.; Fuentes, Eloisa; Ben Trotter; Biju, Raymond; Chhor, Guillaume; Cowan, James; Gendreau, Steven; Lincoln, Webster; McGinnis, Lisa; Molinero, Luciana; Patil, Namrata S.; Schedlbauer, Amber; Schulze, Katja; Stanford-Moore, Adam; Chambre, Laura; Wapinski, Ilan; Shames, David S.; Koeppen, Hartmut; Hennek, Stephanie; Fridlyand, Jane; Giltnane, Jennifer M.; Amitai, Assaf 分享 收藏
Digital SP263 PD-L1 tumor cell scoring in non-small cell lung cancer achieves comparable outcome prediction to manual pathology scoring Prizant, Hen; Shamshoian, John; Abel, John; Beck, Andrew; Chambre, Laura; Hennek, Stephanie; Koeppen, Hartmut; Ruderman, Daniel; Das Thakur, Meghna; Montalto, Michael; Trotter, Benjamin; Wapinski, Ilan; Zou, Wei; Srivastava, Minu K.; Giltnane, Jennifer 分享 收藏
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Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis Kurtova, Antonina, V; Heinlein, Melanie; Haas, Simon; Velten, Lars; Dijkgraaf, Gerrit J. P.; Storm, Elaine E.; Kljavin, Noelyn M.; Boumahdi, Soufiane; Himmels, Patricia; Herault, Aurelie; Mancini, Andrew; Koeppen, Hartmut; Dail, Monique; Yan, Qingxiang; Zhang, Jianhuan; Koch, Ute; Radtke, Freddy; Modrusan, Zora; Metcalfe, Ciara; Piskol, Robert; de Sauvage, Frederic J. 分享 收藏
CD8+T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy CD8 T细胞内源性IL-6信号促进对anti-PD-L1免疫疗法的抵抗 Huseni, Mahrukh A.; Wang, Lifen; Klementowicz, Joanna E.; Yuen, Kobe; Breart, Beatrice; Orr, Christine; Liu, Li-fen; Li, Yijin; Gupta, Vinita; Li, Congfen; Rishipathak, Deepali; Peng, Jing; Senbabaoglu, Yasin; Modrusan, Zora; Keerthivasan, Shilpa; Madireddi, Shravan; Chen, Ying-Jiun; Fraser, Eleanor J.; Leng, Ning; Hamidi, Habib; Koeppen, Hartmut; Ziai, James; Hashimoto, Kenji; Fasso, Marcella; Williams, Patrick; McDermott, David F.; Rosenberg, Jonathan E.; Powles, Thomas; Emens, Leisha A.; Hegde, Priti S.; Mellman, Ira; Turley, Shannon J.; Wilson, Mark S.; Mariathasan, Sanjeev; Molinero, Luciana; Merchant, Mark; West, Nathaniel R. 分享 收藏
Whole-body CDS+ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial 癌症免疫治疗之前和期间的全身CDS T细胞可视化: 1/2期试验 de Ruijter, Laura Kist; van de Donk, Pim P.; Hooiveld-Noeken, Jahlisa S.; Giesen, Danique; Elias, Sjoerd G.; Lub-de Hooge, Marjolijn N.; Oosting, Sjoukje F.; Jalving, Mathilde; Timens, Wim; Brouwers, Adrienne H.; Kwee, Thomas C.; Gietema, Jourik A.; Fehrmann, Rudolf S. N.; Fine, Bernard M.; Bohorquez, Sandra M. Sanabria; Yadav, Mahesh; Koeppen, Hartmut; Jing, Jing; Guelman, Sebastian; Lin, Mark T.; Mamounas, Michael J.; Eastham, Jeffrey Ryan; Kimes, Patrick K.; Williams, Simon P.; Ungewickell, Alexander; de Groot, Derk J. A.; de Vries, Elisabeth G. E. 分享 收藏
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers Cantley, Jennifer; Ye, Xiaofen; Rousseau, Emma; Januario, Tom; Hamman, Brian D.; Rose, Christopher M.; Cheung, Tommy K.; Hinkle, Trent; Soto, Leofal; Quinn, Connor; Harbin, Alicia; Bortolon, Elizabeth; Chen, Xin; Haskell, Roy; Lin, Eva; Yu, Shang-Fan; Del Rosario, Geoff; Chan, Emily; Dunlap, Debra; Koeppen, Hartmut; Martin, Scott; Merchant, Mark; Grimmer, Matt; Broccatelli, Fabio; Wang, Jing; Pizzano, Jennifer; Dragovich, Peter S.; Berlin, Michael; Yauch, Robert L. 分享 收藏
Immune contexture of paediatric cancers 儿科癌症的免疫背景 Das Thakur, Meghna; Franz, Carl J.; Brennan, Laura; Brouwer-Visser, Jurriaan; Tam, Rachel; Korski, Konstanty; Koeppen, Hartmut; Ziai, James; Babitzki, Galina; Ranchere-Vince, Dominique; Vasiljevic, Alexandre; Dijoud, Frederique; Marec-Berard, Perrine; Rochet, Isabelle; Cannarile, Michael A.; Marabelle, Aurelien 分享 收藏
Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma 晚期肝细胞癌对阿特珠单抗联合贝伐单抗的临床反应和耐药性的分子相关性 Zhu, Andrew X.; Abbas, Alexander R.; de Galarreta, Marina Ruiz; Guan, Yinghui; Lu, Shan; Koeppen, Hartmut; Zhang, Wenjun; Hsu, Chih-Hung; He, Aiwu Ruth; Ryoo, Baek-Yeol; Yau, Thomas; Kaseb, Ahmed O.; Burgoyne, Adam M.; Dayyani, Farshid; Spahn, Jessica; Verret, Wendy; Finn, Richard S.; Toh, Han Chong; Lujambio, Amaia; Wang, Yulei 分享 收藏
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors Savill, Kristin M. Zimmerman; Lee, Brian B.; Oeh, Jason; Lin, Jie; Lin, Eva; Chung, Wei-Jen; Young, Amy; Chen, Wennie; Mis, Monika; Mesh, Kathryn; Eastham, Jeffrey; Gnad, Florian; Jiang, Zhaoshi; Stawiski, Eric W.; Haley, Benjamin; Daemen, Anneleen; Wang, Xiaojing; Koeppen, Hartmut; Modrusan, Zora; Martin, Scott E.; Sampath, Deepak; Lin, Kui 分享 收藏
Comparison of SP142 and 22C3 Immunohistochemistry PD-L1 Assays for Clinical Efficacy of Atezolizumab in Non-Small Cell Lung Cancer: Results From the Randomized OAK Trial Gadgeel, Shirish; Hirsch, Fred R.; Kerr, Keith; Barlesi, Fabrice; Park, Keunchil; Rittmeyer, Achim; Zou, Wei; Bhatia, Namrata; Koeppen, Hartmut; Paul, Sarah M.; Shames, David; Yi, Jing; Matheny, Christina; Ballinger, Marcus; McCleland, Mark; Gandara, David R. 分享 收藏
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α Le Thomas, Adrien; Ferri, Elena; Marsters, Scot; Harnoss, Jonathan M.; Lawrence, David A.; Zuazo-Gaztelu, Iratxe; Modrusan, Zora; Chan, Sara; Solon, Margaret; Chalouni, Cecile; Li, Weihan; Koeppen, Hartmut; Rudolph, Joachim; Wang, Weiru; Wu, Thomas D.; Walter, Peter; Ashkenazi, Avi 分享 收藏
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Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer Desbois, Melanie; Udyavar, Akshata R.; Ryner, Lisa; Kozlowski, Cleopatra; Guan, Yinghui; Duerrbaum, Milena; Lu, Shan; Fortin, Jean-Philippe; Koeppen, Hartmut; Ziai, James; Chang, Ching-Wei; Keerthivasan, Shilpa; Plante, Marie; Bourgon, Richard; Bais, Carlos; Hegde, Priti; Daemen, Anneleen; Turley, Shannon; Wang, Yulei 分享 收藏
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