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BCCA7693-A novel, orally bioavailable DNA-PK inhibitor demonstrates efficacy with targeted MAPK and PARP therapeutics by slowing the development of acquired resistance Kyle, A.; Baker, J.; Banath, J.; Teymori, S.; Smiljanic-Hurley, E.; Osborne, S.; Sturino, C.; Mancini, J.; Paquette, J.; Arns, S.; Minchinton, A. 分享 收藏
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects Avet, Charlotte; Sturino, Claudio; Grastilleur, Sebastien; Le Gouill, Christian; Semache, Meriem; Gross, Florence; Gendron, Louis; Bennani, Youssef; Mancini, Joseph A.; Sayegh, Camil E.; Bouvier, Michel 分享 收藏
The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation C3a过敏毒素受体是胰岛素抵抗的关键介质，通过调节脂肪组织巨噬细胞浸润和激活发挥作用 Mamane, Yael; Chan, Chi Chung; Lavallee, Genevieve; Morin, Nicolas; Xu, Li-Jing; Huang, JingQi; Gordon, Robert; Thomas, Winston; Lamb, John; Schadt, Eric E.; Kennedy, Brian P.; Mancini, Joseph A. 分享 收藏
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor Riendeau, D; Percival, MD; Boyce, S; Brideau, C; Charleson, S; Cromlish, W; Ethier, D; Evans, J; Falgueyret, JP; FordHutchinson, AW; Gordon, R; Greig, G; Gresser, M; Guay, J; Kargman, S; Leger, S; Mancini, JA; ONeill, G; Ouellet, M; Rodger, IW; Therien, M; Wang, Z; Webb, JK; Wong, E; Xu, L; Young, RN; Zamboni, R; Prasit, P; Chan, CC 分享 收藏
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets Waddleton, Deena; Wu, Weizhen; Feng, Yue; Thompson, Chris; Wu, Michael; Zhou, Yun-Ping; Howard, Andrew; Thornberry, Nancy; Li, Jing; Mancini, Joseph A. 分享 收藏
L-454,560, a potent and selective PDE4 inhibitor with in vitro efficacy in animal models of asthma and cognition L-454，560，一种有效的选择性PDE4抑制剂，在哮喘和认知动物模型中具有体外功效 Huang, Z.; Dias, R.; Jones, T.; Liu, S.; Styhler, A.; Claveau, D.; Otu, F.; Ng, K.; Laliberte, F.; Zhang, L.; Goetghebeur, P.; Abraham, W. M.; Macdonald, D.; Dub, D.; Gallant, M.; Lacombe, P.; Girard, Y.; Young, R. N.; Turner, M. J.; Nicholson, D. W.; Mancini, J. A. 分享 收藏
Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl) phenyl)-2-(5H)-furanone], in multiple preclinical species Rowland, Steven E.; Clark, Patsy; Gordon, Robert; Mullen, Anne K.; Guay, Jocelyne; Dufresne, Lynn; Brideau, Christine; Cote, Bernard; Ducharme, Yves; Mancini, Joseph; Chan, Chi-chung; Audoly, Laurent; Xu, Daigen 分享 收藏
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Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis 4-[2-(3，4-双-二氟甲氧基苯基)-2-[4-(1,1，1,3，3，3，3-六氟-2-羟基丙-2-基)-苯基]-乙基]-3-甲基吡啶-1-氧化物 (L-826，141) 产生的外周磷酸二酯酶4抑制预防实验性自身免疫性脑脊髓炎 Moore, C. S.; Earl, N.; Frenette, R.; Styhler, A.; Mancini, J. A.; Nicholson, D. W.; Hebb, A. L. O.; Owens, T.; Robertson, G. S. 分享 收藏
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Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-{2-(3,4-bis-difluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor 通过L-826，141 [4-{2-(3，4-二氟甲氧基苯基)-2-{4-(1,1，1,3，3，3-六氟-2-羟基丙-2-基)-苯基]-乙基}-3-甲基吡啶-1-氧化物]，强效选择性磷酸二酯酶4抑制剂 Claveau, D; Chen, SL; O'Keefe, S; Zaller, DM; Styhler, A; Liu, S; Huang, Z; Nicholson, DW; Mancini, JA 分享 收藏
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Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors:: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity Friesen, RW; Ducharme, Y; Ball, RG; Blouin, M; Boulet, L; Côté, B; Frenette, R; Girard, M; Guay, D; Huang, Z; Jones, TR; Laliberté, F; Lynch, JJ; Mancini, J; Martins, E; Masson, P; Muise, E; Pon, DJ; Siegl, PKS; Styhler, A; Tsou, NN; Turner, MJ; Young, RN; Girard, Y 分享 收藏
Comparison of inhibition of ovalbumin-induced bronchoconstriction in guinea pigs and in vitro inhibition of tumor necrosis factor-α formation with phosphodiesterase 4 (PDE4) selective inhibitors 比较卵清蛋白诱导的豚鼠支气管收缩的抑制作用和磷酸二酯酶4 (PDE4) 选择性抑制剂对肿瘤坏死因子-α 形成的体外抑制作用 Muise, ES; Chute, IC; Claveau, D; Masson, P; Boulet, L; Tkalec, L; Pon, DJ; Girard, Y; Frenette, R; Mancini, JA 分享 收藏
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