未登录 12-Lipoxygenase Inhibition Improves Glycemia and Obesity-associated Inflammation in Male Human Gene Replacement Mice 12-脂氧合酶抑制改善雄性人类基因替代小鼠的血糖和肥胖相关炎症 Kaylan, Kerim B.; Nargis, Titli; Figatner, Kayla; Wang, Jiayi E.; Pratuangtham, Sarida; Chakraborty, Advaita; Casimiro, Isabel; Nadler, Jerry L.; Boxer, Matthew B.; Maloney, David J.; Anderson, Ryan M.; Mirmira, Raghavendra G.; Tersey, Sarah A. 分享 收藏
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice Nargis, Titli; Muralidharan, Charanya; Enriquez, Jacob R.; Wang, Jiayi E.; Kaylan, Kerim B.; Chakraborty, Advaita; Pratuangtham, Sarida; Figatner, Kayla; Nelson, Jennifer B.; May, Sarah C.; Nadler, Jerry L.; Boxer, Matthew B.; Maloney, David J.; Tersey, Sarah A.; Mirmira, Raghavendra G. 分享 收藏
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SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers Shi, Lei; Shen, William; Davis, Mindy I.; Kong, Ke; Vu, Phuong; Saha, Supriya K.; Adil, Ramzi; Kreuzer, Johannes; Egan, Regina; Lee, Tobie D.; Greninger, Patricia; Shrimp, Jonathan H.; Zhao, Wei; Wei, Ting-Yu; Zhou, Mi; Eccleston, Jason; Sussman, Jonathan; Manocha, Ujjawal; Weerasekara, Vajira; Kondo, Hiroshi; Vijay, Vindhya; Wu, Meng-Ju; Kearney, Sara E.; Ho, Jeffrey; McClanaghan, Joseph; Murchie, Ellen; Crowther, Giovanna S.; Patnaik, Samarjit; Boxer, Matthew B.; Shen, Min; Ting, David T.; Kim, William Y.; Stanger, Ben Z.; Deshpande, Vikram; Ferrone, Cristina R.; Benes, Cyril H.; Haas, Wilhelm; Hall, Matthew D.; Bardeesy, Nabeel 分享 收藏
Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors Liu, Li; Tang, Manshu; Pragani, Rajan; Whitby, Frank G.; Zhang, Ya-qin; Balakrishnan, Bijina; Fang, Yuhong; Karavadhi, Surendra; Tao, Dingyin; LeClair, Christopher A.; Hall, Matthew D.; Marugan, Juan J.; Boxer, Matthew; Shen, Min; Hill, Christopher P.; Lai, Kent; Patnaik, Samarjit 分享 收藏
The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia Caffall, Zachary F.; Wilkes, Bradley J.; Hernandez-Martinez, Ricardo; Rittiner, Joseph E.; Fox, Jennifer T.; Wan, Kanny K.; Shipman, Miranda K.; Titus, Steven A.; Zhang, Ya-Qin; Patnaik, Samarjit; Hall, Matthew D.; Boxer, Matthew B.; Shen, Min; Li, Zhuyin; Vaillancourt, David E.; Calakos, Nicole 分享 收藏
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer Rohde, Jason M.; Karavadhi, Surendra; Pragani, Rajan; Liu, Li; Fang, Yuhong; Zhang, Weihe; McIver, Andrew; Zheng, Hongchao; Liu, Qingyang; Davis, Mindy, I; Urban, Daniel J.; Lee, Tobie D.; Cheff, Dorian M.; Hollingshead, Melinda; Henderson, Mark J.; Martinez, Natalia J.; Brimacombe, Kyle R.; Yasgar, Adam; Zhao, Wei; Klumpp-Thomas, Carleen; Michael, Sam; Covey, Joseph; Moore, William J.; Stott, Gordon M.; Li, Zhuyin; Simeonov, Anton; Jadhav, Ajit; Frye, Stephen; Hall, Matthew D.; Shen, Min; Wang, Xiaodong; Patnaik, Samarjit; Boxer, Matthew B. 分享 收藏
EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth Issaq, Sameer H.; Mendoza, Arnulfo; Kidner, Ria; Rosales, Tracy, I; Duveau, Damien Y.; Heske, Christine M.; Rohde, Jason M.; Boxer, Matthew B.; Thomas, Craig J.; DeBerardinis, Ralph J.; Helman, Lee J. 分享 收藏
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors Manz, Theresa D.; Sivakumaren, Sindhu C.; Yasgar, Adam; Hall, Matthew D.; Davis, Mindy I.; Seo, Hyuk-Soo; Card, Joseph D.; Ficarro, Scott B.; Shim, Hyeseok; Marto, Jarrod A.; Dhe-Paganon, Sirano; Sasaki, Atsuo T.; Boxer, Matthew B.; Simeonov, Anton; Cantley, Lewis C.; Shen, Min; Zhang, Tinghu; Ferguson, Fleur M.; Gray, Nathanael S. 分享 收藏
High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma Wang, Sarah; Hwang, Elizabeth E.; Guha, Rajarshi; O'Neill, Allison F.; Melong, Nicole; Veinotte, Chansey J.; Saur, Amy Conway; Wuerthele, Kellsey; Shen, Min; McKnight, Crystal; Alexe, Gabriela; Lemieux, Madeleine E.; Wang, Amy; Hughes, Emma; Xu, Xin; Boxer, Matthew B.; Hall, Matthew D.; Kung, Andrew; Berman, Jason N.; Davis, Mindy I.; Stegmaier, Kimberly; Crompton, Brian D. 分享 收藏
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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space Kearney, Sara E.; Zahoranszky-Kohalmi, Gergely; Brimacombe, Kyle R.; Henderson, Mark J.; Lynch, Caitlin; Zhao, Tongan; Wan, Kanny K.; Itkin, Zina; Dillon, Christopher; Shen, Min; Cheff, Dorian M.; Lee, Tobie D.; Bougie, Danielle; Cheng, Ken; Coussens, Nathan P.; Dorjsuren, Dorjbal; Eastman, Richard T.; Huang, Ruili; Iannotti, Michael J.; Karavadhi, Surendra; Klumpp-Thomas, Carleen; Roth, Jacob S.; Sakamuru, Srilatha; Sun, Wei; Titus, Steven A.; Yasgar, Adam; Zhang, Ya-Qin; Zhao, Jinghua; Andrade, Rodrigo B.; Brown, M. Kevin; Burns, Noah Z.; Cha, Jin K.; Mevers, Emily E.; Clardy, Jon; Clement, Jason A.; Crooks, Peter A.; Cuny, Gregory D.; Ganor, Jake; Moreno, Jesus; Morrill, Lucas A.; Picazo, Elias; Susick, Robert B.; Garg, Neil K.; Goess, Brian C.; Grossman, Robert B.; Hughes, Chambers C.; Johnston, Jeffrey N.; Joullie, Madeleine M.; Kinghorn, A. Douglas; Kingston, David G. I.; Krische, Michael J.; Kwon, Ohyun; Maimone, Thomas J.; Majumdar, Susruta; Maloney, Katherine N.; Mohamed, Enas; Murphy, Brian T.; Nagorny, Pavel; Olson, David E.; Overman, Larry E.; Brown, Lauren E.; Snyder, John K.; Porco, John A., Jr.; Rivas, Fatima; Ross, Samir A.; Sarpong, Richmond; Sharma, Indrajeet; Shaw, Jared T.; Xu, Zhengren; Shen, Ben; Shi, Wei; Stephenson, Corey R. J.; Verano, Alyssa L.; Tan, Derek S.; Tang, Yi; Taylor, Richard E.; Thomson, Regan J.; Vosburg, David A.; Wu, Jimmy; Wuest, William M.; Zakarian, Armen; Zhang, Yufeng; Ren, Tianjing; Zuo, Zhong; Inglese, James; Michael, Sam; Simeonov, Anton; Zheng, Wei; Shinn, Paul; Jadhav, Ajit; Boxer, Matthew B.; Hall, Matthew D.; Xia, Menghang; Guha, Rajarshi; Rohde, Jason M. 分享 收藏
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors Rohde, Jason M.; Brimacombe, Kyle R.; Liu, Li; Pacold, Michael E.; Yasgar, Adam; Cheff, Dorian M.; Lee, Tobie D.; Rai, Ganesha; Baljinnyam, Bolormaa; Li, Zhuyin; Simeonov, Anton; Hall, Matthew D.; Shen, Min; Sabatini, David M.; Boxer, Matthew B. 分享 收藏
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma Krepler, Clemens; Sproesser, Katrin; Brafford, Patricia; Beqiri, Marilda; Garman, Bradley; Xiao, Min; Shannan, Batool; Watters, Andrea; Perego, Michela; Zhang, Gao; Vultur, Adina; Yin, Xiangfan; Liu, Qin; Anastopoulos, Ioannis N.; Wubbenhorst, Bradley; Wilson, Melissa A.; Xu, Wei; Karakousis, Giorgos; Feldman, Michael; Xu, Xiaowei; Amaravadi, Ravi; Gangadhar, Tara C.; Elder, David E.; Haydu, Lauren E.; Wargo, Jennifer A.; Davies, Michael A.; Lu, Yiling; Mills, Gordon B.; Frederick, Dennie T.; Barzily-Rokni, Michal; Flaherty, Keith T.; Hoon, Dave S.; Guarino, Michael; Bennett, Joseph J.; Ryan, Randall W.; Petrelli, Nicholas J.; Shields, Carol L.; Terai, Mizue; Sato, Takami; Aplin, Andrew E.; Roesch, Alexander; Darr, David; Angus, Steve; Kumar, Rakesh; Halilovic, Ensar; Caponigro, Giordano; Jeay, Sebastien; Wuerthner, Jens; Walter, Annette; Ocker, Matthias; Boxer, Matthew B.; Schuchter, Lynn; Nathanson, Katherine L.; Herlyn, Meenhard 分享 收藏
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays Urban, Daniel J.; Martinez, Natalia J.; Davis, Mindy I.; Brimacombe, Kyle R.; Cheff, Dorian M.; Lee, Tobie D.; Henderson, Mark J.; Titus, Steven A.; Pragani, Rajan; Rohde, Jason M.; Liu, Li; Fang, Yuhong; Karavadhi, Surendra; Shah, Pranav; Lee, Olivia W.; Wang, Amy; McIver, Andrew; Zheng, Hongchao; Wang, Xiaodong; Xu, Xin; Jadhav, Ajit; Simeonov, Anton; Shen, Min; Boxer, Matthew B.; Hall, Matthew D. 分享 收藏
High-throughput chemical screening identifies Focal Adhesion Kinase and Aurora Kinase B inhibition as a synergistic treatment combination in Ewing sarcoma Crompton, Brian; Wang, Sarah; Hwang, Elizabeth; Guha, Rajarshi; Boxer, Matthew; McKnight, Crystal; Shen, Min; Melong, Nicole; Veinotte, Chansey; Conway, Amy; Berman, Jason; Hall, Matthew; Davis, Mindy; Stegmaier, Kimberly 分享 收藏
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A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect (vol 5, 3608, 2014) Lopez-Serra, Paula; Marcilla, Miguel; Villanueva, Alberto; Ramos-Fernandez, Antonio; Palau, Anna; Leal, Lucia; Wahi, Jessica E.; Setien-Baranda, Fernando; Szczesna, Karolina; Moutinho, Catia; Martinez-Cardus, Anna; Heyn, Holger; Sandoval, Juan; Puertas, Sara; Vidal, August; Sanjuan, Xavier; Martinez-Balibrea, Eva; Vinals, Francesc; Perales, Jose C.; Bramsem, Jesper B.; Orntoft, Torben F.; Andersen, Claus L.; Tabernero, Josep; McDermott, Ultan; Boxer, Matthew B.; Heiden, Matthew G. Vander; Albar, Juan Pablo; Esteller, Manel 分享 收藏
Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models Davis, Mindy I.; Pragani, Rajan; Fox, Jennifer T.; Shen, Min; Parmar, Kalindi; Gaudiano, Emily F.; Liu, Li; Tanega, Cordelle; McGee, Lauren; Hall, Matthew D.; McKnight, Crystal; Shinn, Paul; Nelson, Henrike; Chattopadhyay, Debasish; D'Andrea, Alan D.; Auld, Douglas S.; DeLucas, Larry J.; Li, Zhuyin; Boxer, Matthew B.; Sinneonov, Anton 分享 收藏
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