未登录 A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides Zacharias, Neelie; Podust, Vladimir N.; Kajihara, Kimberly K.; Leipold, Douglas; Del Rosario, Geoffrey; Thayer, Desiree; Dong, Emily; Paluch, Maciej; Fischer, David; Zheng, Kai; Lei, Corinna; He, Jintang; Ng, Carl; Su, Dian; Liu, Luna; Masih, Shabkhaiz; Sawyer, William; Tinianow, Jeff; Marik, Jan; Yip, Victor; Li, Guangmin; Chuh, Josefa; Morisaki, J. Hiroshi; Park, Summer; Zheng, Bing; Hernandez-Barry, Hilda; Loyet, Kelly M.; Xu, Min; Kozak, Katherine R.; Phillips, Gail Lewis; Shen, Ben-Quan; Wu, Cong; Xu, Keyang; Yu, Shang-Fan; Kamath, Amrita; Rowntree, Rebecca K.; Reilly, Dorothea; Pillow, Thomas; Polson, Andrew; Schellenberger, Volker; Hazenbos, Wouter L. W.; Sadowsky, Jack 分享 收藏
Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response Dela Cruz Chuh, Josefa; Go, MaryAnn; Chen, Yvonne; Guo, Jun; Rafidi, Hanine; Mandikian, Danielle; Sun, Yonglian; Lin, Zhonghua; Schneider, Kellen; Zhang, Pamela; Vij, Rajesh; Sharpnack, Danielle; Chan, Pamela; de la Cruz, Cecile; Sadowsky, Jack; Seshasayee, Dhaya; Koerber, James T.; Pillow, Thomas H.; Phillips, Gail D.; Rowntree, Rebecca K.; Boswell, C. Andrew; Kozak, Katherine R.; Polson, Andrew G.; Polakis, Paul; Yu, Shang-Fan; Dragovich, Peter S.; Agard, Nicholas J. 分享 收藏
Improved translation of stability for conjugated antibodies using an in vitro whole blood assay Fourie-O'Donohue, Aimee; Chu, Phillip Y.; Chuh, Josefa dela Cruz; Tchelepi, Robert; Tsai, Siao Ping; Tran, John C.; Sawyer, William S.; Su, Dian; Ng, Carl; Xu, Keyang; Yu, Shang-Fan; Pillow, Thomas H.; Sadowsky, Jack; Dragovich, Peter S.; Liu, Yichin; Kozak, Katherine R. 分享 收藏
Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker Dragovich, Peter S.; Blake, Robert A.; Chen, Chunjiao; Chen, Jinhua; Chuh, Josefa; den Besten, Willem; Fan, Fang; Fourie, Aimee; Hartman, Steven J.; He, Changrong; He, Jintang; Ingalla, Ellen Rei; Kozak, Katherine R.; Leong, Steven R.; Lu, Jiawei; Ma, Yong; Meng, Lingyao; Nannini, Michelle; Oeh, Jason; Ohri, Rachana; Phillips, Gail Lewis; Pillow, Thomas H.; Rowntree, Rebecca K.; Sampath, Deepak; Vandlen, Richard; Vollmar, Breanna; Wai, John; Wertz, Ingrid E.; Xu, Keyang; Xu, Zijin; Zhang, Donglu 分享 收藏
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity Wei, BinQing; Gunzner-Toste, Janet; Yao, Hui; Wang, Tao; Wang, Jing; Xu, Zijin; Chen, Jinhua; Wai, John; Nonomiya, Jim; Tsai, Siao Ping; Chuh, Josefa; Kozak, Katherine R.; Liu, Yichin; Yu, Shang-Fan; Lau, Jeff; Li, Guangmin; Phillips, Gail D.; Leipold, Doug; Kamath, Amrita; Su, Dian; Xu, Keyang; Eigenbrot, Charles; Steinbacher, Stefan; Ohri, Rachana; Raab, Helga; Staben, Leanna R.; Zhao, Guiling; Flygare, John A.; Pillow, Thomas H.; Verma, Vishal; Masterson, Luke A.; Howard, Philip W.; Safina, Brian 分享 收藏
Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates Caculitan, Nina G.; Chuh, Josefa dela Cruz; Ma, Yong; Zhang, Donglu; Kozak, Katherine R.; Liu, Yichin; Pillow, Thomas H.; Sadowsky, Jack; Cheung, Tommy K.; Phung, Qui; Haley, Benjamin; Lee, Byoung-Chul; Akita, Robert W.; Sliwkowski, Mark X.; Polson, Andrew G. 分享 收藏
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates Staben, Leanna R.; Koenig, Stefan G.; Lehar, SophieM.; Vandlen, Richard; Zhang, Donglu; Chuh, Josefa; Yu, Shang-Fan; Ng, Carl; Guo, Jun; Liu, Yanzhou; Fourie-O'Donohue, Aimee; Go, MaryAnn; Xin Linghu; Segraves, Nathaniel L.; Wang, Tao; Chen, Jinhua; Wei, BinQing; Phillips, Gail D. Lewis; Xu, Keyang; Kozak, Katherine R.; Mariathasan, Sanjeev; Flygare, John A.; Pillow, Thomas H. 分享 收藏
An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models Scales, Suzie J.; Gupta, Nidhi; Pacheco, Glenn; Firestein, Ron; French, Dorothy M.; Koeppen, Hartmut; Rangell, Linda; Barry-Hamilton, Vivian; Luis, Elizabeth; Chuh, Josefa; Zhang, Yin; Ingle, Gladys S.; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Ross, Sarajane; Dennis, Mark S.; Spencer, Susan D. 分享 收藏
Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate Gupta, Nidhi; Solis, Willy A.; Fuji, Reina N.; Oldendorp, Amy; Pacheco, Glenn; Luis, Elizabeth; Chuh, Josefa; French, Dorothy M.; Drake, Elizabeth; Dennis, Mark S.; Kozak, Katherine R.; Ross, Sarajane; Tibbitts, Jay; Spencer, Susan D.; Scales, Suzie J. 分享 收藏
A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers Scales, Suzie J.; Gupta, Nidhi; Pacheco, Glenn; Firestein, Ron; French, Dorothy M.; Chuh, Josefa; Zhang, Yin; Berry, Leanne; Bostrom, Jenny; Luis, Elizabeth; O'Donohue, Aimee Fourie; Kozak, Katherine R.; Ross, Sarajane; Dennis, Mark S.; Tibbitts, Jay; Spencer, Susan D. 分享 收藏
Site-Specific Trastuzumab Maytansinoid Antibody-Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering Pillow, Thomas H.; Tien, Janet; Parsons-Reponte, Kathryn L.; Bhakta, Sunil; Li, Hao; Staben, Leanna R.; Li, Guangmin; Chuh, Josefa; Fourie-O'Donohue, Aimee; Darwish, Martine; Yip, Victor; Liu, Luna; Leipold, Douglas D.; Su, Dian; Wu, Elmer; Spencer, Susan D.; Shen, Ben-Quan; Xu, Keyang; Kozak, Katherine R.; Raab, Helga; Vandlen, Richard; Phillips, Gail D. Lewis; Scheller, Richard H.; Polakis, Paul; Sliwkowski, Mark X.; Flygare, John A.; Junutula, Jagath R. 分享 收藏
DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma Li, Dongwei; Poon, Kirsten Achilles; Yu, Shang-Fan; Dere, Randall; Go, MaryAnn; Lau, Jeffrey; Zheng, Bing; Elkins, Kristi; Danilenko, Dimitry; Kozak, Katherine R.; Chan, Pamela; Chuh, Josefa; Shi, Xiaoyan; Nazzal, Denise; Fuh, Franklin; McBride, Jacqueline; Ramakrishnan, Vanitha; de Tute, Ruth; Rawstron, Andy; Jack, Andrew S.; Deng, Rong; Chu, Yu-Waye; Dornan, David; Williams, Marna; Ho, William; Ebens, Allen; Prabhu, Saileta; Polson, Andrew G. 分享 收藏
Total Antibody Quantification for MMAE-Conjugated Antibody-Drug Conjugates: Impact of Assay Format and Reagents Kozak, Katherine R.; Tsai, Siao Ping; Fourie-O'Donohue, Aimee; Chuh, Josefa dela Cruz; Roth, Leslie; Cook, Ryan; Chan, Elton; Chan, Pamela; Darwish, Martine; Ohri, Rachana; Raab, Helga; Zhang, Crystal; Lin, Kedan; Wong, Wai Lee T. 分享 收藏
Micro-volume wall-less immunoassays using patterned planar plates Kozak, Katherine R.; Wang, Jianyong; Lye, Melvin; Chuh, Josefa dela Cruz; Takkar, Rashi; Kim, Namyong; Lee, Hyunjae; Jeon, Noo Li; Lin, Kedan; Zhang, Crystal; Wong, Wai Lee T.; DeForge, Laura E. 分享 收藏
Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model Pastuskovas, Cinthia V.; Mundo, Eduardo E.; Williams, Simon P.; Nayak, Tapan K.; Ho, Jason; Ulufatu, Sheila; Clark, Suzanna; Ross, Sarajane; Cheng, Eric; Parsons-Reponte, Kathryn; Cain, Gary; Van Hoy, Marjie; Majidy, Nicholas; Bheddah, Sheila; Chuh, Josefa dela Cruz; Kozak, Katherine R.; Lewin-Koh, Nicholas; Nauka, Peter; Bumbaca, Daniela; Sliwkowski, Mark; Tibbitts, Jay; Theil, Frank-Peter; Fielder, Paul J.; Khawli, Leslie A.; Boswell, C. Andrew 分享 收藏
Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody-Drug Conjugates in Rats Boswell, C. Andrew; Mundo, Eduardo E.; Zhang, Crystal; Bumbaca, Daniela; Valle, Nicole R.; Kozak, Katherine R.; Fourie, Aimee; Chuh, Josefa; Koppada, Neelima; Saad, Ola; Gill, Herman; Shen, Ben-Quan; Rubinfeld, Bonnee; Tibbitts, Jay; Kaur, Surinder; Theil, Frank-Peter; Fielder, Paul J.; Khawli, Leslie A.; Lin, Kedan 分享 收藏
In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates Zheng, Bing; Fuji, Reina N.; Elkins, Kristi; Yu, Shang-Fan; Fuh, Franklin K.; Chuh, Josefa; Tan, Christine; Hongo, Jo-Anne; Raab, Helga; Kozak, Katherine R.; Williams, Marna; McDorman, Elena; Eaton, Dan; Ebens, Allen; Polson, Andrew G. 分享 收藏
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