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收藏分享 收藏 分享 收藏 H1-0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemiaH1-0是前白血病和B细胞急性淋巴细胞白血病中抑制性ETV6::RUNX1转录景观的特异性介导因子。
Jepsen, Vera H.; Hanel, Andrea; Picard, Daniel; Bhave, Rigveda; Hasselmann, Rebecca; Mehtonen, Juha; Schliehe-Diecks, Julian; Kath, Carla-Johanna; Suppiyar, Vithusan; Prasad, Yash; Schaal, Katerina; Tu, Jia-Wey; Ruechel, Nadine; Kameri, Ersen; Qin, Nan; Wang, Herui; Zhuang, Zhengping; Wagener, Rabea; Bluemel, Lena; Lautwein, Tobias; Hein, Daniel; Koppstein, David; Koegler, Gesine; Remke, Marc; Heinaeniemi, Merja; Borkhardt, Arndt; Fischer, Ute 分享 收藏 An in vitro pharmacogenomic approach reveals subtype-specific therapeutic vulnerabilities in atypical teratoid/rhabdoid tumors (AT/RT)一种体外药理基因组学方法揭示了不典型性畸胎瘤/横纹肌样瘤(AT/RT)中特定亚型的治疗易感位点。Pauck, David; Picard, Daniel; Maue, Mara; Taban, Kuebra; Marquardt, Viktoria; Bluemel, Lena; Bartl, Jasmin; Qin, Nan; Kubon, Nadezhda; Schoendorf, Dominik; Meyer, Frauke-Dorothee; Theruvath, Johanna; Mitra, Siddhartha; Hasselblatt, Martin; Fruehwald, Michael C.; Remke, Marc 分享 收藏 Alpha/beta values in pediatric medulloblastoma: implications for tailored approaches in radiation oncologyJazmati, Danny; Sohn, Dennis; Hoerner-Rieber, Juliane; Qin, Nan; Boelke, Edwin; Haussmann, Jan; Schwarz, Rudolf; Niggemeier, Niklas David; Borkhardt, Arndt; Babor, Florian; Brozou, Triantafyllia; Felek, Melissa; Tamaskovics, Balint; Melchior, Patrick; Beez, Thomas; Timmermann, Beate; Remke, Marc; Corradini, Stefanie; Schulz, Remi Till; Preugschas, Ronja-Linda; Budach, Wilfried; Matuschek, Christiane 分享 收藏 Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma CellsKrings, Karina S.; Wassenberg, Tobias R.; Cea-Medina, Pablo; Schmitt, Laura; Lechtenberg, Ilka; Llewellyn, Tanya R.; Qin, Nan; Gohlke, Holger; Wesselborg, Sebastian; Mueller, Thomas J. J. 分享 收藏 A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases临床兼容的体外药物筛选平台可确定脑转移原代培养物中的治疗脆弱性Jeising, Sebastian; Nickel, Ann-Christin; Truebel, Johanna; Felsberg, Joerg; Picard, Daniel; Leprivier, Gabriel; Wolter, Marietta; Huynh, My Ky; Olivera, Marlene B.; Kaulich, Kerstin; Haeberle, Lena; Esposito, Irene; Klau, Gunnar W.; Steinmann, Julia; Beez, Thomas; Rapp, Marion; Sabel, Michael; Dietrich, Sascha; Remke, Marc; Cornelius, Jan F.; Reifenberger, Guido; Qin, Nan 分享 收藏 Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2Schmitt, Laura; Lechtenberg, Ilka; Driessen, Daniel; Flores-Romero, Hector; Skowron, Margaretha A.; Sekeres, Marlena; Hoppe, Julia; Krings, Karina S.; Llewellyn, Tanya R.; Peter, Christoph; Stork, Bjorn; Qin, Nan; Bhatia, Sanil; Nettersheim, Daniel; Fritz, Gerhard; Garcia-Saez, Ana J.; Mueller, Thomas J. J.; Wesselborg, Sebastian 分享 收藏 Drug-repurposing by virtual and experimental screening of PFKFB3 inhibitors for pancreatic cancer therapyCao, Xin; Jiang, Xiao; Zhong, Zhi-Xin; Li, Xu-Zhao; Liu, Lu; Li, Xiao-Lei; Yu, Yang; Chen, Ying; Qin, Nan; Ni, Tian-Wen; Duan, Hong-Quan; Duan, Xiao-Chuan 分享 收藏 Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures具有MYCN扩增的小儿高级别神经胶质瘤小鼠模型揭示了肿瘤内异质性和谱系特征Schoof, Melanie; Godbole, Shweta; Albert, Thomas K.; Dottermusch, Matthias; Walter, Carolin; Ballast, Annika; Qin, Nan; Olivera, Marlena Baca; Goebel, Carolin; Neyazi, Sina; Holdhof, Doerthe; Kresbach, Catena; Peter, Levke-Sophie; Epplen, Gefion Dorothea; Thaden, Vanessa; Spohn, Michael; Blattner-Johnson, Mirjam; Modemann, Franziska; Mynarek, Martin; Rutkowski, Stefan; Sill, Martin; Varghese, Julian; Afflerbach, Ann-Kristin; Eckhardt, Alicia; Muenter, Daniel; Verma, Archana; Struve, Nina; Jones, David T. W.; Remke, Marc; Neumann, Julia E.; Kerl, Kornelius; Schueller, Ulrich 分享 收藏 A CLINICALLY COMPATIBLE IN VITRODRUG-SCREENING PLATFORM IDENTIFIES THERAPEUTIC VULNERABILITIES IN PRIMARY CULTURES OF BRAIN METASTASESJeising, S.; Truebel, J.; Felsberg, J.; Picard, D.; Wolter, M.; Kaulich, K.; Haeberle, L.; Esposito, I.; Steinmann, J.; Cornelius, J.; Beez, T.; Rapp, M.; Sabel, M.; Nickel, A.; Remke, M.; Reifenberger, G.; Qin, N. 分享 收藏 Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma整合多组学揭示了两个生物学上不同的毛细胞星形细胞瘤组Picard, Daniel; Felsberg, Joerg; Langini, Maike; Stachura, Pawel; Qin, Nan; Macas, Jadranka; Reiss, Yvonne; Bartl, Jasmin; Selt, Florian; Sigaud, Romain; Meyer, Frauke-D.; Stefanski, Anja; Stuehler, Kai; Roque, Lucia; Roque, Rafael; Pandyra, Aleksandra A.; Brozou, Triantafyllia; Knobbe-Thomsen, Christiane; Plate, Karl H.; Roesch, Alexander; Milde, Till; Reifenberger, Guido; Leprivier, Gabriel; Faria, Claudia C.; Remke, Marc 分享 收藏 分享 收藏 UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic diseasePaisana, Eunice; Cascao, Rita; Custodia, Carlos; Qin, Nan; Picard, Daniel; Pauck, David; Carvalho, Tania; Ruivo, Pedro; Barreto, Clara; Doutel, Delfim; Cabecadas, Jose; Roque, Rafael; Pimentel, Jose; Miguens, Jose; Remke, Marc; Barata, Joao T.; Faria, Claudia C. 分享 收藏 Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammationMarquardt, Viktoria; Theruvath, Johanna; Pauck, David; Picard, Daniel; Qin, Nan; Bluemel, Lena; Maue, Mara; Bartl, Jasmin; Ahmadov, Ulvi; Langini, Maike; Meyer, Frauke-Dorothee; Cole, Allison; Cruz-Cruz, Joselyn; Graef, Claus M.; Woelfl, Matthias; Milde, Till; Witt, Olaf; Erdreich-Epstein, Anat; Leprivier, Gabriel; Kahlert, Ulf; Stefanski, Anja; Stuehler, Kai; Keir, Stephen T.; Bigner, Darell D.; Hauer, Julia; Beez, Thomas; Knobbe-Thomsen, Christiane B.; Fischer, Ute; Felsberg, Jörg; Hansen, Finn K.; Vibhakar, Rajeev; Venkatraman, Sujatha; Cheshier, Samuel H.; Reifenberger, Guido; Borkhardt, Arndt; Kurz, Thomas; Remke, Marc; Mitra, Siddhartha 分享 收藏 分享 收藏 Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumorsBluemel, Lena; Qin, Nan; Berlandi, Johannes; Paisana, Eunice; Cascao, Rita; Custodia, Carlos; Pauck, David; Picard, Daniel; Langini, Maike; Stuehler, Kai; Meyer, Frauke-Dorothee; Goebbels, Sarah; Malzkorn, Bastian; Liebau, Max C.; Barata, Joao T.; Jeibmann, Astrid; Kerl, Kornelius; Erkek, Serap; Kool, Marcel; Pfister, Stefan M.; Johann, Pascal D.; Fruehwald, Michael C.; Borkhardt, Arndt; Reifenberger, Guido; Faria, Claudia C.; Fischer, Ute; Hasselblatt, Martin; Bartl, Jasmin; Remke, Marc 分享 收藏 Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer胃癌对HDAC抑制的敏感性与RTK/MAPK通路的激活有关Seidlitz, Therese; Schmaeche, Tim; Garcia, Fernando; Lee, Joon Ho; Qin, Nan; Kochall, Susan; Fohgrub, Juliane; Pauck, David; Rothe, Alexander; Koo, Bon-Kyoung; Weitz, Juergen; Remke, Marc; Munoz, Javier; Stange, Daniel E. 分享 收藏 The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumorsBartl, Jasmin; Zanini, Marco; Bernardi, Flavia; Forget, Antoine; Bluemel, Lena; Talbot, Julie; Picard, Daniel; Qin, Nan; Cancila, Gabriele; Gao, Qingsong; Nath, Soumav; Koumba, Idriss Mahoungou; Wolter, Marietta; Kuonen, Francois; Langini, Maike; Beez, Thomas; Munoz, Christopher; Pauck, David; Marquardt, Viktoria; Yu, Hua; Souphron, Judith; Korsch, Mascha; Moelders, Christina; Berger, Daniel; Goebbels, Sarah; Meyer, Frauke-Dorothee; Scheffler, Bjorn; Rotblat, Barak; Diederichs, Sven; Ramaswamy, Vijay; Suzuki, Hiromishi; Oro, Anthony; Stuehler, Kai; Stefanski, Anja; Fischer, Ute; Leprivier, Gabriel; Willbold, Dieter; Steger, Gerhard; Buell, Alexander; Kool, Marcel; Lichter, Peter; Pfister, Stefan M.; Northcott, Paul A.; Taylor, Michael D.; Borkhardt, Arndt; Reifenberger, Guido; Ayrault, Olivier; Remke, Marc 分享 收藏 
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