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C

Christian Ottmann

eindhoven university of technology

52H指数
497论文数
8.6K被引数
收录论文 76
发表时间
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Modulation of the 14-3-3σ/C-RAF “Auto”inhibited Complex by Molecular Glues分子胶对14-3-3σ/c-raf “自动” 抑制复合物的调制
errJournal of the American Chemical Society
IF15.6
err2026-01-30
err0
errOAAI
errMarkella Konstantinidou; Holly R. Vickery; Marloes A. M. Pennings; Johanna M. Virta; Shu Yue Luo; Emira J. Visser; Sean D. Bannier; Mrudula Srikanth; Sabine Z. Cismoski; Lucy C. Young; Maxime C. M. van den Oetelaar; Frank McCormick; Christian Ottmann; Luc Brunsveld; Michelle R. Arkin
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Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship用于14-3-3/ChREBP相互作用的大环分子胶: 成反比关系的亲和力和协同性
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2025-12-01
err0
errOAAI
errPennings, Marloes A. M.; van den Bosch, Merel A. W.; Oberheide, Ansgar; Verhoef, Carlo J. A.; Ottmann, Christian; Markvoort, Albert J.; Miley, Galen P.; Brunsveld, Luc
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Identifying 14-3-3 interactome binding sites with deep learning利用深度学习识别14-3-3互作组结合位点
errDigital Discovery
IF5.6
err2025-08-08
err0
errOAAI
errLaura D van Weesep; Riza Ozcelik; Marloes Pennings; Emanuele Criscuolo; Christian Ottmann; Luc Brunsveld; Francesca Grisoni
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Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation化学计量14-3-3ζ结合促进磷酸化Tau微管解离并减少聚集和凝聚
errCommunications Biology
IF5.1
err2025-07-31
err0
errOAAI
errJanine Hochmair; Maxime C. M. van den Oetelaar; Leandre Ravatt; Lisa Diez; Lenne J. M. Lemmens; Renata Ponce-Lina; Rithika Sankar; Maximilian Franck; Gesa Nolte; Ekaterina Semenova; Satabdee Mohapatra; Christian Ottmann; Luc Brunsveld; Susanne Wegmann
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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex针对14-3-3/ERα复合物的骨架跳跃分子胶开发
errNature Communications
IF15.7
err2025-07-14
err0
errOAAI
errMarkella Konstantinidou; Marios Zingiridis; Marloes A. M. Pennings; Michael Fragkiadakis; Johanna M. Virta; Jezrael L. Revalde; Emira J. Visser; Christian Ottmann; Luc Brunsveld; Constantinos G. Neochoritis; Michelle R. Arkin
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The three body solution: Structural insights into molecular glues
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2025-04-01
err0
errOAAI
errTomlinson, Aidan C. A.; Knox, John E.; Brunsveld, Luc; Ottmann, Christian; Yano, Jason K.
err分享
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Site-specific molecular glues for the 14-3-3/Tau pS214 protein-protein interaction via reversible covalent imine tethering
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err0
errOAAI
errOberheide, Ansgar; van den Oetelaar, Maxime C. M.; Scheele, Jakob J. A.; Borggraefe, Jan; Engelen, Semmy F. H.; Sattler, Michael; Ottmann, Christian; Cossar, Peter J.; Brunsveld, Luc
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14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-04-18
err0
errOAAI
errHeesink, Gobert; van den Oetelaar, Maxime C. M.; Semerdzhiev, Slav A.; Ottmann, Christian; Brunsveld, Luc; Blum, Christian; Claessens, Mireille M. A. E.
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A simple method for developing lysine targeted covalent protein reagents
errNATURE COMMUNICATIONS
IF15.7
err2023-12-01
err11
errOAAI
errGabizon, Ronen; Tivon, Barr; Reddi, Rambabu N.; van den Oetelaar, Maxime C. M.; Amartely, Hadar; Cossar, Peter J.; Ottmann, Christian; London, Nir
err分享
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Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3s/ERa Protein-Protein Interaction from Nonselective Fragments
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-09-07
err15
errOAAI
errKonstantinidou, Markella; Visser, Emira J.; Vandenboorn, Edmee; Chen, Sheng; Jaishankar, Priyadarshini; Overmans, Maurits; Dutta, Shubhankar; Neitz, R. Jeffrey; Renslo, Adam R.; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R.
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From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2023-08-01
err9
errOAAI
errVisser, Emira J.; Jaishankar, Priyadarshini; Sijbesma, Eline; Pennings, Marloes A. M.; Vandenboorn, Edmee M. F.; Guillory, Xavier; Neitz, R. Jeffrey; Morrow, John; Dutta, Shubhankar; Renslo, Adam R.; Brunsveld, Luc; Arkin, Michelle R.; Ottmann, Christian
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Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-07-01
err5
errOAAI
errSomsen, Bente A.; Sijbesma, Eline; Leysen, Seppe; Honzejkova, Karolina; Visser, Emira J.; Cossar, Peter J.; Obsil, Tomas; Brunsveld, Luc; Ottmann, Christian
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IFNa primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization
errCELL CHEMICAL BIOLOGY
IF7.2
err2023-06-01
err13
errOAAI
errAndlovic, Blaz; Heilmann, Geronimo; Ninck, Sabrina; Andrei, Sebastian A.; Centorrino, Federica; Higuchi, Yusuke; Kato, Nobuo; Brunsveld, Luc; Arkin, Michelle; Menninger, Sascha; Choidas, Axel; Wolf, Alexander; Klebl, Bert; Kaschani, Farnusch; Kaiser, Markus; Eickhoff, Jan; Ottmann, Christian
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A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers
errACS CENTRAL SCIENCE
IF10.4
err2023-04-18
err22
errOAAI
errKenanova, Dyana N.; Visser, Emira J.; Virta, Johanna M.; Sijbesma, Eline; Centorrino, Federica; Vickery, Holly R.; Zhong, Mengqi; Neitz, R. Jeffrey; Brunsveld, Luc; Ottmann, Christian; Arkin, Michelle R.
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Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR? Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach14-3-3/ERR的可逆双共价分子锁定？蛋白质-蛋白质相互作用作为分子胶药物发现方法
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-03-16
err20
errOAAI
errSomsen, Bente A.; Schellekens, Rick J. C.; Verhoef, Carlo J. A.; Arkin, Michelle R.; Ottmann, Christian; Cossar, Peter J.; Brunsveld, Luc
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Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction(vol 65, pg 16818, 2022)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-01-28
err0
errOAAI
errPallesen, Jakob S.; Munier, Claire C.; Bosica, Francesco; Andrei, Sebastian A.; Edman, Karl; Gunnarsson, Anders; La Sala, Giuseppina; Putra, Okky Dwichandra; Srdanovic, Sonja; Wilson, Andrew J.; Wissler, Lisa; Ottmann, Christian; Perry, Matthew W. D.; O'Mahony, Gavin
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Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-12-09
err8
errOAAI
errPallesen, Jakob S.; Munier, Claire C.; Bosica, Francesco; Andrei, Sebastian A.; Edman, Karl; Gunnarsson, Anders; La Sala, Giuseppina; Putra, Okky Dwichandra; Srdanovic, Sonja; Wilson, Andrew J.; Wissler, Lisa; Ottmann, Christian; Perry, Matthew W. D.; O'Mahony, Gavin
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Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3
errACS CHEMICAL BIOLOGY
IF3.8
err2022-10-18
err9
errOAAI
errBrink, Hendrik J.; van Senten, Jeffrey R.; De Vries-van Leeuwen, Ingrid J.; Pereira, Daniel da Costa; Piersma, Sander R.; Jimenez, Connie R.; Centorrino, Federica; Ottmann, Christian; Siderius, Marco; Smit, Martine J.; de Boer, Albertus H.
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Indazole MRL-871 interacts with PPARγ via a binding mode that induces partial agonism
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2022-08-01
err3
errOAAI
errLeijten-van de Gevel, Iris A.; van Herk, Kim H. N.; de Vries, Rens M. J. M.; Ottenheym, Nicolaas J.; Ottmann, Christian; Brunsveld, Luc
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Molecular glues to stabilise protein-protein interactions
errCURRENT OPINION IN CHEMICAL BIOLOGY
IF6.1
err2022-08-01
err22
errOAAI
errSoini, Lorenzo; Leysen, Seppe; Davis, Jeremy; Ottmann, Christian
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研究方向

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合作学者
合作期刊
A
Alfred Wittinghofer
H 指数: 105 · 论文数: 514
H
Henning Urlaub
H 指数: 102 · 论文数: 737
D
David Y. Thomas
H 指数: 89 · 论文数: 357
N
Nico A. J. M. Sommerdijk
H 指数: 76 · 论文数: 416
M
Michael Sattler
H 指数: 76 · 论文数: 572
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