未登录 Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis Zhang, Xiaojun; Jiang, Wen; Richter, Jeremy M.; Bates, J. Alex; Reznik, Samuel K.; Stachura, Sylwia; Rampulla, Richard; Doddalingappa, Dyamanna; Ulaganathan, Sankar; Hua, Ji; Bostwick, Jeffrey S.; Sum, Chi; Posy, Shana; Malmstrom, Sarah; Dickey, Joyce; Harden, David; Lawrence, R. Michael; Guarino, Victor R.; Schumacher, William A.; Wong, Pancras; Yang, Jing; Gordon, David A.; Wexler, Ruth R.; Priestley, Scott 分享 收藏
Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure Meng, Wei; Pi, Zulan; Brigance, Robert; Rossi, Karen A.; Schumacher, William A.; Bostwick, Jeffrey S.; Gargalovic, Peter S.; Onorato, Joelle M.; Luk, Chiuwa E.; Generaux, Claudia N.; Wang, Tao; Wexler, Ruth R.; Finlay, Heather J. 分享 收藏
Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists Pi, Zulan; Johnson, James A.; Meng, Wei; Phillips, Monique; Schumacher, William A.; Bostwick, Jeffrey S.; Gargalovic, Peter S.; Onorato, Joelle M.; Generaux, Claudia N.; Wang, Tao; He, Yan; Gordon, David A.; Wexler, Ruth R.; Finlay, Heather J. 分享 收藏
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate Johnson, James A.; Kim, Soong-Hoon; Jiang, Ji; Phillips, Monique; Schumacher, William A.; Bostwick, Jeffrey S.; Gargalovic, Peter S.; Onorato, Joelle M.; Luk, Chiuwa E.; Generaux, Claudia; He, Yan; Chen, Xue-Qing; Xu, Carrie; Galella, Michael A.; Wang, Tao; Gordon, David A.; Wexler, Ruth R.; Finlay, Heather J. 分享 收藏
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding Wong, Pancras C.; Seiffert, Dietmar; Bird, J. Eileen; Watson, Carol A.; Bostwick, Jeffrey S.; Giancarli, Mary; Allegretto, Nick; Hua, Ji; Harden, David; Guay, Jocelyne; Callejo, Mario; Miller, Michael M.; Lawrence, R. Michael; Banville, Jacques; Guy, Julia; Maxwell, Brad D.; Priestley, E. Scott; Marinier, Anne; Wexler, Ruth R.; Bouvier, Michel; Gordon, David A.; Schumacher, William A.; Yang, Jing 分享 收藏
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4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1 Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution Qiao, Jennifer X.; Wang, Tammy C.; Hiebert, Sheldon; Hu, Carol H.; Schumacher, William A.; Spronk, Steven A.; Clark, Charles G.; Han, Ying; Hua, Ji; Price, Laura A.; Shen, Hong; Chacko, Silvi A.; Everlof, Gerry; Bostwick, Jeffrey S.; Steinbacher, Thomas E.; Li, Yi-Xin; Huang, Christine S.; Seiffert, Dietmar A.; Rehfuss, Robert; Wexler, Ruth R.; Lam, Patrick Y. S. 分享 收藏
Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist Qiao, Jennifer X.; Wang, Tammy C.; Ruel, Rejean; Thibeault, Carl; L'Heureux, Alexandre; Schumacher, William A.; Spronk, Steven A.; Hiebert, Sheldon; Bouthillier, Gilles; Lloyd, John; Pi, Zulan; Schnur, Dora M.; Abell, Lynn M.; Hua, Ji; Price, Laura A.; Liu, Eddie; Wu, Qimin; Steinbacher, Thomas E.; Bostwick, Jeffrey S.; Chang, Ming; Zheng, Joanna; Gao, Qi; Ma, Baoqing; McDonnell, Patricia A.; Huang, Christine S.; Rehfuss, Robert; Wexler, Ruth R.; Lam, Patrick Y. S. 分享 收藏
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Discovery of 2-(Phenoxypyridine)-3-phenylureas as Small Molecule P2Y1 Antagonists Chao, Hannguang; Turdi, Huji; Herpin, Timothy F.; Roberge, Jacques Y.; Liu, Yalei; Schnur, Dora M.; Poss, Michael A.; Rehfuss, Robert; Hua, Ji; Wu, Qimin; Price, Laura A.; Abell, Lynn M.; Schumacher, William A.; Bostwick, Jeffrey S.; Steinbacher, Thomas E.; Stewart, Anne B.; Ogletree, Martin L.; Huang, Christine S.; Chang, Ming; Cacace, Angela M.; Arcuri, Maredith J.; Celani, Deborah; Wexler, Ruth R.; Lawrence, R. Michael 分享 收藏
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Design, Structure-Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors Shi, Yan; Sitkoff, Doree; Zhang, Jing; Klei, Herbert E.; Kish, Kevin; Liu, Eddie C. -K.; Hartl, Karen S.; Seiler, Steve M.; Chang, Ming; Huang, Christine; Youssef, Sonia; Steinbacher, Thornas E.; Schumacher, William A.; Grazier, Nyeemah; Pudzianowski, Andrew; Apedo, Atsu; Discenza, Lorell; Yanchunas, Joseph, Jr.; Stein, Philip D.; Atwal, Karnail S. 分享 收藏
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Is exogenous tissue plasminogen activator necessary for antithrombotic efficacy of an inhibitor of thrombin activatable fibrinolysis inhibitor (TAFI) in rats? Bird, Eileen; Tamura, James; Bostwick, Jeffrey S.; Steinbacher, Thomas E.; Stewart, Anne; Liu, Yizhi; Baumann, Jergen; Feyen, Jean; Tamasi, Joseph; Schumacher, William A. 分享 收藏
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Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice Wang, X; Cheng, Q; Xu, L; Feuerstein, GZ; Hsu, MY; Smith, PL; Seiffert, DA; Schumacher, WA; Ogletree, ML; Gailani, D 分享 收藏
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