未登录Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes突变IDH1与NPM1c或FLT3ITD协同作用，驱动不同的髓系疾病和分子结局。
Sakamoto, Takashi; Leca, Julie; Zhang, Xin; Meydan, Cem; Foox, Jonathan; Ramachandran, Parameswaran; Hendrikse, Liam D.; Zhou, Wenjing; Berger, Thorsten; Fortin, Jerome; Chan, Steven M.; Chiang, Ming-Feng; Inoue, Satoshi; Li, Wanda Y.; Chu, Mandy F.; Duncan, Gordon S.; Wakeham, Andrew; Lemonnier, Francois; Tobin, Chantal; Mcwilliam, Ryan; Colonna, Isabelle; Bontoux, Christophe; Jafari, Soode Moghadas; Bowman, Robert L.; Nicolay, Brandon; Ronseaux, Sebastien; Narayanaswamy, Rohini; Levine, Ross L.; Melnick, Ari M.; Mason, Christopher E.; Minden, Mark D. .png)
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收藏Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing gliomaChuntova, Pavlina; Yamamichi, Akane; Chen, Tiffany; Narayanaswamy, Rohini; Ronseaux, Sebastien; Hudson, Christine; Tron, Adriana E.; Hyer, Marc L.; Montoya, Megan; Mende, Abigail L.; Nejo, Takahide; Downey, Kira M.; Diebold, David; Lu, Min; Nicolay, Brandon; Okada, Hideho 分享 收藏 Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemiaEnasidenib诱导的分化促进IDH2-mutated急性髓系白血病对venetoclax的敏感性Cathelin, Severine; Sharon, David; Subedi, Amit; Cojocari, Dan; Phillips, Darren C.; Leverson, Joel D.; MacBeth, Kyle J.; Nicolay, Brandon; Narayanaswamy, Rohini; Ronseaux, Sebastien; Liu, Guowen; Chan, Steven M. 分享 收藏 The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model丙酮酸激酶激活剂mitapivat在 β-地中海贫血小鼠模型中减少溶血并改善贫血Matte, Alessandro; Federti, Enrica; Kung, Charles; Kosinski, Penelope A.; Narayanaswamy, Rohini; Russo, Roberta; Federico, Giorgia; Carlomagno, Francesca; Desbats, Maria Andrea; Salviati, Leonardo; Leboeuf, Christophe; Valenti, Maria Teresa; Turrini, Francesco; Janin, Anne; Yu, Shaoxia; Beneduce, Elisabetta; Ronseaux, Sebastien; Iatcenko, Iana; Dang, Lenny; Ganz, Tomas; Jung, Chun-Ling; Iolascon, Achille; Brugnara, Carlo; De Franceschi, Lucia 分享 收藏 分享 收藏 Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate DehydrogenaseMcDonald, Gabrielle; Chubukov, Victor; Coco, John; Truskowski, Kevin; Narayanaswamy, Rohini; Choe, Sung; Steadman, Mya; Artin, Erin; Padyana, Anil K.; Jin, Lei; Ronseaux, Sebastien; Locuson, Charles; Fan, Zi-Peng; Erdmann, Tabea; Mann, Alan; Hayes, Sebastian; Fletcher, Mark; Nellore, Kavitha; Rao, Siva Sanjeeva; Subramanya, Hosahalli; Reddy, K. Satish; Panigrahi, Sunil K.; Antony, Thomas; Gopinath, Sreevalsam; Sui, Zhihua; Nagaraja, Nelamangala; Dang, Lenny; Lenz, Georg; Hurov, Jonathan; Biller, Scott A.; Murtie, Josh; Marks, Kevin M.; Ulanet, Danielle B. 分享 收藏 The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinomaWu, Meng-Ju; Shi, Lei; Dubrot, Juan; Hudson, Christine; Merritt, Joshua; Adil, Ramzi; Wu, Qibiao; Ronseaux, Sebastien; Narayanaswamy, Rohini; Manguso, Robert; Nicolay, Brandon; Bardeesy, Nabeel 分享 收藏 Preclinical toxicology profile of squalene epoxidase inhibitorsNagaraja, Raj; Olaharski, Andrew; Narayanaswamy, Rohini; Mahoney, Christopher; Pirman, David; Gross, Stefan; Roddy, Thomas P.; Popovici-Muller, Janeta; Smolen, Gromoslaw A.; Silverman, Lee 分享 收藏 分享 收藏 分享 收藏 Structure and inhibition mechanism of the catalytic domain of human squalene epoxidasePadyana, Anil K.; Gross, Stefan; Jin, Lei; Cianchetta, Giovanni; Narayanaswamy, Rohini; Wang, Feng; Wang, Rui; Fang, Cheng; Lv, Xiaobing; Biiler, Scott A.; Dang, Lenny; Mahoney, Christopher E.; Nagaraja, Nelamangala; Pirman, David; Sui, Zhihua; Popovici-Muller, Janeta; Smolen, Gromoslaw A. 分享 收藏 A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition化学生物学筛选确定了神经内分泌癌细胞对SQLE抑制的脆弱性Mahoney, Christopher E.; Pirman, David; Chubukov, Victor; Sleger, Taryn; Hayes, Sebastian; Fan, Zi Peng; Allen, Eric L.; Chen, Ying; Huang, Lingling; Liu, Meina; Zhang, Yingjia; McDonald, Gabrielle; Narayanaswamy, Rohini; Choe, Sung; Chen, Yue; Gross, Stefan; Cianchetta, Giovanni; Padyana, Anil K.; Murray, Stuart; Liu, Wei; Marks, Kevin M.; Murtie, Joshua; Dorsch, Marion; Jin, Shengfang; Nagaraja, Nelamangala; Biller, Scott A.; Roddy, Thomas; Popovici-Muller, Janeta; Smolen, Gromoslaw A. 分享 收藏 A chemical biology screen identifies a unique vulnerability of neuroendocrine cancer cells to SQLE inhibition化学生物学筛选确定了神经内分泌癌细胞对SQLE抑制的独特脆弱性Mahoney, Christopher; Pirman, David; Chubukov, Victor; Sleger, Taryn; Padyana, Anil; Gross, Stefan; Hayes, Sebastian; Fan, Zi Peng; McDonald, Gabrielle; Chen, Yu; Murtie, Joshua; Cianchetta, Giovanni; Nagaraja, Raj; Narayanaswamy, Rohini; Choe, Sung; Murray, Stuart; Jin, Shengfang; Biller, Scott; Roddy, Thomas; Smolen, Gromoslaw A. 分享 收藏 The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid developmentLemonnier, Francois; Cairns, Rob A.; Inoue, Satoshi; Li, Wanda Y.; Dupuy, Aurelie; Broutin, Sophie; Martin, Nadine; Fataccioli, Virginie; Pelletier, Romain; Wakeham, Andrew; Snow, Bryan E.; de Leval, Laurence; Pujals, Anais; Haioun, Corinne; Paci, Angelo; Tobin, Erica R.; Narayanaswamy, Rohini; Yen, Katherine; Jin, Shengfang; Gaulard, Philippe; Mak, Tak W. 分享 收藏 分享 收藏 Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered miceHao, Zhenyue; Cairns, Rob A.; Inoue, Satoshi; Li, Wanda Y.; Sheng, Yi; Lemonnier, Francois; Wakeham, Andrew; Snow, Bryan E.; Dominguez-Brauer, Carmen; Ye, Jing; Larsen, Dana M.; Straley, Kimberly S.; Tobin, Erica R.; Narayanaswamy, Rohini; Gaulard, Philippe; Mak, Tak W. 分享 收藏 分享 收藏 
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