Clark Distelhorst

University System of Ohio

H指数:47

被引数:8,678

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Creating a New Cancer Therapeutic Agent by Targeting the Interaction between Bcl-2 and IP3 Receptors

通过靶向Bcl-2和IP3受体之间的相互作用创建新的癌症治疗剂

cold spring harbor perspectives in medicine

IF8.4

2019-05-2022

OAAI

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

CANCER RESEARCH

IF16.6

2016-05-3191

OAAI

Glucocorticoids downregulate Fyn and inhibit IP3-mediated calcium signaling to promote autophagy in T lymphocytes

糖皮质激素下调Fyn并抑制IP3-mediated钙信号促进T淋巴细胞自噬

AUTOPHAGY

IF14.3

2014-10-2767

OAAI

The regulation of the ER-mitochondria-Ca2+cross-talk by Bcl-2 and Bcl-XL: A new scenario for the development of selective tools in oncology?

CANCER RESEARCH

IF16.6

2014-05-150

PRE

Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-01-0654

OAAI

IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2

CELL DEATH & DISEASE

IF9.6

2013-05-1697

OAAI

Acidosis Promotes Bcl-2 Family-mediated Evasion of Apoptosis INVOLVEMENT OF ACID-SENSING G PROTEIN-COUPLED RECEPTOR GPR65 SIGNALING TO MEK/ERK

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2012-08-0158

OAAI

Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes (vol 286, pg 30181, 2011)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-11-010

OAAI

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: Role in Ca2+ signaling and disease

Bcl-2与肌醇1,4，5-三磷酸受体的相互作用: 在Ca2信号和疾病中的作用

CELL CALCIUM

IF4

2011-09-0179

OAAI

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

CELL DEATH AND DIFFERENTIATION

IF15.4

2011-08-05162

OAAI

Glucocorticoid Elevation of Dexamethasone-induced Gene 2 (Dig2/RTP801/REDD1) Protein Mediates Autophagy in Lymphocytes

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-08-0183

OAAI

Glucocorticoid-mediated Inhibition of Lck Modulates the Pattern of T Cell Receptor-induced Calcium Signals by Down-regulating Inositol 1,4,5-Trisphosphate Receptors

糖皮质激素介导的Lck抑制通过下调肌醇1,4，5-三磷酸受体来调节T细胞受体诱导的钙信号的模式

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2009-11-0149

OAAI

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

Bcl-2的BH4结构域通过结合IP3受体的调节和偶联结构域来抑制ER钙释放和凋亡

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2009-08-25286

OAAI

The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect

Bcl-2的细胞浓度决定其促凋亡或抗凋亡作用

CELL CALCIUM

IF4

2008-09-0144

OAAI

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content

CELL CALCIUM

IF4

2008-09-0199

PRE

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

MOLECULAR CELL

IF16.6

2008-07-01226

Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes

AUTOPHAGY

IF14.3

2008-07-0158

OAAI

Dexamethasone-induced inositol 1,4,5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2008-04-0119

OAAI

Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis (vol 25, pg 1903, 2006)

ONCOGENE

IF7.3

2008-02-210

Bcl-2-regulated calcium signals as common mediators of both apoptosis and autophagy

DEVELOPMENTAL CELL

IF8.7

2007-02-0138

Clark Distelhorst

个人简介

教育背景

工作经历

荣誉奖项

研究方向