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A Protein Relational Database and Protein Family Knowledge Bases to Facilitate Structure-Based Design Analyses 蛋白质关系数据库和蛋白质家族知识库，以促进基于结构的设计分析 Mobilio, Dominick; Walker, Gary; Brooijmans, Natasja; Nilakantan, Ramaswamy; Denny, R. Aldrin; DeJoannis, Jason; Feyfant, Eric; Kowticwar, Rupesh K.; Mankala, Jyoti; Palli, Satish; Punyamantula, Sairam; Tatipally, Maneesh; John, Reji K.; Humblet, Christine 分享 收藏
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Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90 Gopalsamy, Ariamala; Shi, Mengxiao; Golas, Jennifer; Vogan, Erik; Jacob, Jaison; Johnson, Mark; Lee, Frederick; Nilakantan, Ramaswamy; Petersen, Roseann; Svenson, Kristin; Chopra, Rajiv; Tam, May S.; Wen, Yingxia; Ellingboe, John; Arndt, Kim; Boschelli, Frank 分享 收藏
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Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design Tsao, Desiree H. H.; Sutherland, Alan G.; Jennings, Lee. D.; Li, Yuanhong; Rush, Thomas S., III; Alvarez, Juan C.; Ding, Weidong; Dushin, Elizabeth G.; Dushin, Russell G.; Haney, Steve A.; Kenny, Cynthia H.; Malakian, A. Karl; Nilakantan, Ramaswamy; Mosyak, Lidia 分享 收藏
2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2 Wissner, A; Floyd, MB; Johnson, BD; Fraser, H; Ingalls, C; Nittoli, T; Dushin, RG; Discafani, C; Nilakantan, R; Marini, J; Ravi, M; Cheung, K; Tan, X; Musto, S; Annable, T; Siegel, MM; Loganzo, F 分享 收藏
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity Tsou, HR; Overbeek-Klumpers, EG; Hallett, WA; Reich, MF; Floyd, MB; Johnson, BD; Michalak, RS; Nilakantan, R; Discafani, C; Golas, J; Rabindran, SK; Shen, R; Shi, XQ; Wang, YF; Upeslacis, J; Wissner, A 分享 收藏
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase Rabindran, SK; Discafani, CM; Rosfjord, EC; Baxter, M; Floyd, MB; Golas, J; Hallett, WA; Johnson, BD; Nilakantan, R; Overbeek, E; Reich, MF; Shen, R; Shi, XQ; Tsou, HR; Wang, YF; Wissner, A 分享 收藏
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2) Wissner, A; Overbeek, E; Reich, MF; Floyd, MB; Johnson, BD; Mamuya, N; Rosfjord, EC; Discafani, C; Davis, R; Shi, XQ; Rabindran, SK; Gruber, BC; Ye, F; Hallett, WA; Nilakantan, R; Shen, R; Wang, YF; Greenberger, LM; Tsou, HR 分享 收藏
6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity Tsou, HR; Mamuya, N; Johnson, BD; Reich, MF; Gruber, BC; Ye, F; Nilakantan, R; Shen, R; Discafani, C; DeBlanc, R; Davis, R; Koehn, FE; Greenberger, LM; Wang, YF; Wissner, A 分享 收藏
Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design Chen, JM; Nelson, FC; Levin, JI; Mobilio, D; Moy, FJ; Nilakantan, R; Zask, A; Powers, R 分享 收藏
4-Anilino-6,7-dialkoxyquinolime-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors Wissner, A; Berger, DM; Boschelli, DH; Floyd, MB; Greenberger, LM; Gruber, BC; Johnson, BD; Mamuya, N; Nilakantan, R; Reich, MF; Shen, R; Tsou, HR; Upeslacis, E; Wang, YF; Wu, BQ; Ye, F; Zhang, N 分享 收藏
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Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785) Discafani, CM; Carroll, ML; Floyd, MB; Hollander, IJ; Husain, Z; Johnson, BD; Kitchen, D; May, MK; Malo, MS; Minnick, AA; Nilakantan, R; Shen, R; Wang, YF; Wissner, A; Greenberger, LM 分享 收藏
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