未登录Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models推进结直肠癌精准治疗：利用患者源性异种移植模型开发多靶点激酶抑制剂BPR1J481的临床适应症
Tang, Ya-Chu; Ou, Jing-Jim; Hsu, Shu-Ching; Huang, Chih-Hsiang; Lin, Li-Mei; Chang, Hsin-Huei; Wang, Yi-Hsin; Huang, Zih-Ting; Sun, Manwu; Liu, Ko-Jiunn; Hung, Yi-Mei; Lai, Chi-Yun; Shih, Chuan; Chen, Chiung-Tong; Chang, Jang-Yang; Jiaang, Weir-Torn; Kuo, Ching-Chuan .png)
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收藏Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesiaHuang, Yi-Han; Lin, Shu-Yu; Ou, Li-Chin; Huang, Wei-Cheng; Chao, Po-Kuan; Chang, Yung-Chiao; Chang, Hsiao-Fu; Lee, Pin-Tse; Yeh, Teng-Kuang; Kuo, Yu-Hsien; Tien, Ya-Wen; Xi, Jing-Hua; Tao, Pao-Luh; Chen, Pin-Yuan; Chuang, Jian-Ying; Shih, Chuan; Chen, Chiung-Tong; Tung, Chun-Wei; Loh, Horace H.; Ueng, Shau-Hua; Yeh, Shiu-Hwa 分享 收藏 DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral AdministrationLin, Shu-Yu; Chang, Yung-Chiao; Tien, Ya-Wen; Kuo, Yu-Hsien; Chang, Hsiao-Fu; Ou, Li-Chin; Chen, Ya-Ping; Chang, Kuei-Hua; Hsu, Ying-Ting; Huang, Yu-Chen; Yang, Chen-Ming; Law, Ping-Yee; Xi, Jing-Hua; Tao, Pao-Luh; Loh, Horace H.; Yeh, Teng-Kuang; Zhuang, Hong; Hsieh, Hsing-Pang; Shih, Chuan; Chen, Chiung-Tong; Yeh, Shiu-Hwa; Ueng, Shau-Hua 分享 收藏 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipationKuppusamy, Ramajayam; Hsu, Ying-Ting; Ke, Yi-Yu; Chang, Po-Wei; Chang, Yung-Chiao; Chang, Hsiao-Fu; Wang, Pei-Chen; Lin, Yu-Hao; Huang, Yu-Chen; Yeh, Teng-Kuang; Chuang, Jian-Ying; Loh, Horace H.; Shih, Chuan; Chen, Chiung-Tong; Yeh, Shiu-Hwa; Ueng, Shau-Hua 分享 收藏 Discovery and development of a novel N-(3-bromophenyl)- {[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design使用基于知识的药物设计发现和开发新型N-(3-溴苯基)- {[(苯基氨基甲酰基) 氨基] 甲基}-N-hydroxythiophene-2-carboximidamide吲哚胺2，3-双加氧酶抑制剂Yeh, Teng-Kuang; Song, Jen-Shin; Chang, Po-Wei; Yu, Jin-Chen; Chang, Chia-Hwa; Liao, Fang-Yu; Tien, Ya-Wen; Kuppusamy, Ramajayam; Li, An-Siou; Chen, Chi-Han; Chen, Chieh-Wen; Lin, Li-Mei; Chang, Hsin-Huei; Huang, Chih-Hsiang; Yao, Jau-Ying; Wu, Mine-Hsine; Peng, Yi-Hui; Hsueh, Ching-Cheng; Hsiao, Wen-Chi; Chen, Pei-Husan; Lin, Chin-Yu; Hsieh, Su-Huei; Shih, Chuan; Hung, Ming-Shiu; Wu, Su-Ying; Kuo, Ching-Chuan; Ueng, Shau-Hua 分享 收藏 Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor ModelLee, Kun-Hung; Yen, Wan-Ching; Lin, Wen-Hsing; Wang, Pei-Chen; Lai, You-Liang; Su, Yu-Chieh; Chang, Chun-Yu; Wu, Cai-Syuan; Huang, Yu-Chen; Yang, Chen-Ming; Chou, Ling-Hui; Yeh, Teng-Kuang; Chen, Chiung-Tong; Shih, Chuan; Hsieh, Hsing-Pang 分享 收藏 Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC OncoproteinsChi, Ya-Hui; Yeh, Teng-Kuang; Ke, Yi-Yu; Lin, Wen-Hsing; Tsai, Chia-Hua; Wang, Wan-Ping; Chen, Yen-Ting; Su, Yu-Chieh; Wang, Pei-Chen; Chen, Yan-Fu; Wu, Zhong-Wei; Yeh, Jen-Yu; Hung, Ming-Chun; Wu, Mine-Hsine; Wang, Jing-Ya; Chen, Ching-Ping; Song, Jen-Shin; Shih, Chuan; Chen, Chiung-Tong; Chang, Chun-Ping 分享 收藏 Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discoveryTsou, Lun K.; Yeh, Shiu-Hwa; Ueng, Shau-Hua; Chang, Chun-Ping; Song, Jen-Shin; Wu, Mine-Hsine; Chang, Hsiao-Fu; Chen, Sheng-Ren; Shih, Chuan; Chen, Chiung-Tong; Ke, Yi-Yu 分享 收藏 BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplificationChi, Ya-Hui; Chang, Chun-Ping; Ke, Yi-Yu; Lin, Wen-Hsing; Wang, Wan-Ping; Tsai, Chia-Hua; Chen, Yen-Ting; Su, Yu-Jie; Hung, Ming-Chun; Wu, Zhong-Wei; Wu, Mine-Hsine; Yeh, Teng-Kuang; Chen, Ching-Ping; Song, Jen-Shin; Chen, Chiung-Tong; Shih, Chuan 分享 收藏 Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors (vol 63, pg 1642, 2020)Peng, Yi-Hui; Liao, Fang-Yu; Tseng, Chen-Tso; Kuppusamy, Ramajayam; Li, An-Siou; Chen, Chi-Han; Fan, Yu-Shiou; Wang, Sing-Yi; Wu, Mine-Hsine; Hsueh, Ching-Cheng; Chang, Jia-Yu; Lee, Lung-Chun; Shih, Chuan; Shia, Kak-Shan; Yeh, Teng-Kuang; Hung, Ming-Shiu; Kuo, Ching-Chuan; Song, Jen-Shin; Wu, Su-Ying; Ueng, Shau-Hua 分享 收藏 Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase InhibitorsPeng, Yi-Hui; Liao, Fang-Yu; Tseng, Chen-Tso; Kuppusamy, Ramajayam; Li, An-Siou; Chen, Chi-Han; Fan, Yu-Shiou; Wang, Sing-Yi; Wu, Mine-Hsine; Hsueh, Ching-Cheng; Chang, Jia-Yu; Lee, Lung-Chun; Shih, Chuan; Shia, Kak-Shan; Yeh, Teng-Kuang; Hung, Ming-Shiu; Kuo, Ching-Chuan; Song, Jen-Shin; Wu, Su-Ying; Ueng, Shau-Hua 分享 收藏 Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid LeukemiaLin, Wen-Hsing; Wu, Su-Ying; Yeh, Teng-Kuang; Chen, Chiung-Tong; Song, Jen-Shin; Shiao, Hui-Yi; Kuo, Ching-Chuan; Hsu, Tsu; Lu, Cheng-Tai; Wang, Pei-Chen; Wu, Tsung-Sheng; Peng, Yi-Hui; Lin, Hui-You; Chen, Ching-Ping; Weng, Ya-Ling; Kung, Fang-Chun; Wu, Mine-Hsine; Su, Yu-Chieh; Huang, Kuo-Wei; Chou, Ling-Hui; Hsueh, Ching-Cheng; Yen, Kuei-Jung; Kuo, Po-Chu; Huang, Chen-Lung; Chen, Li-Tzong; Shih, Chuan; Tsai, Hui-Jen; Jiaang, Weir-Torn 分享 收藏 Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216Kuo, Ching-Chuan; Jiaang, Weir-Torn; Ou, Jing-Jim; Chen, Chiung-Tong; Hsu, Shu-Ching; Shih, Chuan; Lin, Li-Mei; Sun, Manwu; Wang, Yi-Hsin; Huang, Zih-Ting; Chang, Jang-Yang; Ueng, Shau-Hua 分享 收藏 An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancerChang, Chun-Ping; Ke, Yi-Yu; Lin, Wen-Hsing; Jhuo, Dai-Hui; Wang, Wan-Ping; Tsai, Chia-Hua; Chen, Yen-Ting; Su, Yu-Jie; Hung, Ming-Chun; Wu, Zhong-Wei; Kuo, Po-Chu; Yeh, Teng-Kuang; Chen, Ching-Ping; Song, Jen-Shin; Chen, Chiun-Tong; Shih, Chuan; Chi, Ya-Hui 分享 收藏 Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug ConjugatesLiu, Yu-Wei; Chen, Yun-Yu; Hsu, Chia-Yu; Chiu, Tai-Yu; Liu, Kuan-Liang; Lo, Chen-Fu; Fang, Ming-Yu; Huang, Yu-Cheng; Yeh, Teng-Kuang; Pak, Koon Y.; Gray, Brian D.; Hsu, Tsu-An; Huang, Kuan-Hsun; Shih, Chuan; Shia, Kak-Shan; Chen, Chiung-Tong; Tsou, Lun K. 分享 收藏 The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxoneN-phenyl-2 ′，4 ′-dimethyl-4，5 ′-bi-1，3-噻唑-2-胺和纳洛酮组合的体内镇痛和 μ 阿片受体激活作用Lin, Shu-Yu; Kuo, Yu-Hsien; Tien, Ya-Wen; Ke, Yi-Yu; Chang, Wan-Ting; Chang, Hsiao-Fu; Ou, Li-Chin; Law, Ping-Yee; Xi, Jing-Hua; Tao, Pao-Luh; Loh, Horace H.; Chao, Yu-Sheng; Shih, Chuan; Chen, Chiung-Tong; Yeh, Shiu-Hwa; Ueng, Shau-Hua 分享 收藏 Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibitionKe, Yi-Yu; Chang, Chun-Ping; Lin, Wen-Hsing; Tsai, Chia-Hua; Chiu, I-Chen; Wang, Wan-Ping; Wang, Pei-Chen; Chen, Pei-Yi; Lin, Wen-Hsin; Chang, Chun-Feng; Kuo, Po-Chu; Song, Jen-Shin; Shih, Chuan; Hsieh, Hsing-Pang; Chi, Ya-Hui 分享 收藏 Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase InhibitorsYeh, Teng-Kuang; Kuo, Ching-Chuan; Lee, Yue-Zhi; Ke, Yi-Yu; Chu, Kuang-Feng; Hsu, Hsing-Yu; Chang, Hsin-Yu; Liu, Yu-Wei; Song, Jen-Shin; Yang, Cheng-Wei; Lin, Li-Mei; Sun, Manwu; Wu, Szu-Huei; Kuo, Po-Chu; Shih, Chuan; Chen, Chiung-Tong; Tsou, Lun Kelvin; Lee, Shiow-Ju 分享 收藏 分享 收藏 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than MorphineChao, Po-Kuan; Ueng, Shau-Hua; Ou, Li-Chin; Yeh, Teng-Kuang; Chang, Wan-Ting; Chang, Hsiao-Fu; Chen, Shu-Chun; Tao, Pao-Luh; Law, Ping-Yee; Loh, Horace H.; Cheng, Ming-Fu; Chuang, Jian-Ying; Chen, Chiung-Tong; Shih, Chuan; Yeh, Shiu-Hwa 分享 收藏 
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