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收藏Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
Wagner, BL; Valledor, AF; Shao, G; Daige, CL; Bischoff, ED; Petrowski, M; Jepsen, K; Baek, SH; Heyman, RA; Rosenfeld, MG; Schulman, IG; Glass, CK 分享 收藏 Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927Kahraman, Mehmet; Govek, Steven P.; Nagasawa, Johnny Y.; Lai, Andiliy; Bonnefous, Celine; Douglas, Karensa; Sensintaffar, John; Liu, Nhin; Lee, KyoungJin; Aparicio, Anna; Kaufman, Josh; Qian, Jing; Slaw, Gang; Prudente, Rene; Joseph, James D.; Darimont, Beatrice; Brigham, Daniel; Heyman, Richard; Rix, Peter J.; Hager, Jeffrey H.; Smith, Nicholas D. 分享 收藏 Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast CancerNagasawa, Johnny; Govek, Steven; Kahraman, Mehmet; Lai, Andiliy; Bonnefous, Celine; Douglas, Karensa; Sensintaffar, John; Lu, Nhin; Lee, KyoungJin; Aparicio, Anna; Kaufman, Josh; Qian, Jing; Shao, Gang; Prudente, Rene; Joseph, James D.; Darimont, Beatrice; Brigham, Daniel; Maheu, Kate; Heyman, Richard; Rix, Peter J.; Hager, Jeffrey H.; Smith, Nicholas D. 分享 收藏 Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER plus breast cancer: From GDC-0810 to GDC-0927Kahraman, Mehmet; Govek, Steven P.; Nagasawa, Johnny Y.; Lai, Andiliy; Bonnefous, Celine; Douglas, Karensa; Sensintaffar, John; Lu, Nhin; Lee, KyoungJin; Aparicio, Anna; Kaufman, Josh; Qian, Jing; Shao, Gang; Prudente, Rene; Joseph, James D.; Darimont, Beatrice; Brigham, Daniel; Heyman, Richard; Rix, Peter J.; Hager, Jeffrey H.; Smith, Nicholas D.; Blake, Robert A.; Chang, Jae; Choo, Edna; Daemen, Anneleen; Friedman, Lori S.; Guan, Jane; Hartman, Steven; Ingalla, Ellen; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada; Metcalfe, Ciara; Mody, Vidhi; Nannini, Michelle; Sampath, Deepak; Young, Amy; Vinogradova, Maia; Zhou, Wei; Liang, Jun; Wang, Xiaojing 分享 收藏 The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER plus breast cancerJoseph, James D.; Darimont, Beatrice; Zhou, Wei; Arrazate, Alfonso; Young, Amy; Ingalla, Ellen; Walter, Kimberly; Blake, Robert A.; Nonomiya, Jim; Guan, Zhengyu; Kategaya, Lorna; Govek, Steven P.; Lai, Andiliy G.; Kahraman, Mehmet; Brigham, Dan; Sensintaffar, John; Lui, Nhin; Sheo, Gang; Qian, Jing; Grillot, Kate; Moon, Michael; Prudente, Rene; Bischoff, Eric; Lee, Kyoung-Jin; Bonnefous, Celine; Douglas, Karensa L.; Julien, Jackaline D.; Nagasawa, Johnny Y.; Aparicio, Anna; Kaufman, Josh; Haley, Benjamin; Giltnane, Jennifer M.; Wertz, Ingrid E.; Lackner, Mark R.; Nannini, Michelle A.; Sampath, Deepak; Schwarz, Luis; Manning, Henry Charles; Tantawy, Mohammed Noor; Arteaga, Carlos L.; Heyman, Richard A.; Rix, Peter J.; Friedman, Lori; Smith, Nicholas D.; Metcalfe, Ciara; Hager, Jeffrey H. 分享 收藏 Discovery of GDC-0810 a novel, non-steroidal selective estrogen receptor degrader with robust activity in pre-clinical models of endocrine-resistant breast cancerJoseph, James; Govek, Steven; Darimont, Beatrice; Brigham, Daniel; Aparicio, Anna; Bischoff, Eric; Kahraman, Mehmet; Nannini, Michelle; Kaufman, Joshua; Lai, Andily; Lee, Kyoung-Jin; Oeh, Jason; Lu, Nhin; Zhou, Wei; Moon, Michael; Qian, Jing; Sensintaffar, John; Shao, Gang; Sampath, Deepak; Friedman, Lori S.; Rix, Peter; Heyman, Richard A.; Smith, Nicholas; Hager, Jeffrey H. 分享 收藏 Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer XenograftsLai, Andiliy; Kahraman, Mehmet; Govek, Steven; Nagasawa, Johnny; Bonnefous, Celine; Julien, Jackie; Douglas, Karensa; Sensintaffar, John; Lu, Nhin; Lee, Kyoung-jin; Aparicio, Anna; Kaufman, Josh; Qian, Jing; Shao, Gang; Prudente, Rene; Moon, Michael J.; Joseph, James D.; Darimont, Beatrice; Brigham, Daniel; Grillot, Kate; Heyman, Richard; Rix, Peter J.; Hager, Jeffrey H.; Smith, Nicholas D. 分享 收藏 A novel class of selective estrogen receptors degraders regresses tumors in pre-clinical models of endocrine-resistant breast cancerDarimont, Beatrice; Govek, Steven; Lu, Nihn; Nagasawa, Johnny; Prudente, Rene; Qian, Jing; Sensintaffar, John; Shao, Gang; Heyman, Richard; Rix, Peter; Smith, Nicholas; Hager, Jeffrey; Joseph, James; Grillot, Katherine; Aparicio, Anna; Bischoff, Eric; Kahraman, Mehmet; Kaufman, Josh; Lai, Andiliy; Lee, Kyoung-Jin 分享 收藏 Novel selective estrogen receptors degraders regress tumors in pre-clinical models of endocrine-resistant breast cancerHager, J. H.; Darimont, B.; Joseph, J.; Govek, S.; Grillot, K.; Aparicio, A.; Bischoff, E.; Kahraman, M.; Kaufman, J.; Lai, A.; Lee, K-J; Lu, N.; Nagasawa, J.; Prudente, R.; Qian, J.; Sensintaffar, J.; Shao, G.; Heyman, R.; Rix, P.; Smith, N. D. 分享 收藏 ARN-509: A Novel Antiandrogen for Prostate Cancer TreatmentClegg, Nicola J.; Wongvipat, John; Joseph, James D.; Tran, Chris; Ouk, Samedy; Dilhas, Anna; Chen, Yu; Grillot, Kate; Bischoff, Eric D.; Cal, Ling; Aparicio, Anna; Dorow, Steven; Arora, Vivek; Shao, Gang; Qian, Jing; Zhao, Hong; Yang, Guangbin; Cao, Chunyan; Sensintaffar, John; Wasielewska, Teresa; Herbert, Mark R.; Bonnefous, Celine; Darimont, Beatrice; Scher, Howard I.; Smith-Jones, Peter; Klang, Mark; Smith, Nicholas D.; De Stanchina, Elisa; Wu, Nian; Ouerfelli, Ouathek; Rix, Peter J.; Heyman, Richard A.; Jung, Michael E.; Sawyers, Charles L.; Hager, Jeffrey H. 分享 收藏 分享 收藏 分享 收藏 Biological characterization of a heterodimer-selective retinoid X receptor modulator: Potential benefits for the treatment of type 2 diabetesLeibowitz, MD; Ardecky, RJ; Boehm, MF; Broderick, CL; Carfagna, MA; Crombie, DL; D'Arrigo, J; Etgen, GJ; Faul, MM; Grese, TA; Havel, H; Hein, NI; Heyman, RA; Jolley, D; Klausing, K; Liu, S; Mais, DE; Mapes, CM; Marschke, KB; Michellys, PV; Montrose-Rafizadeh, C; Ogilvie, KM; Pascual, B; Rungta, D; Tyhonas, JS; Urcan, MS; Wardlow, M; Yumibe, N; Reifel-Miller, A 分享 收藏 分享 收藏 Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand雌激素相关受体 α (err α) 配体对ppar γ 共激活因子1 α (PGC-1α) 信号的调节Willy, PJ; Murray, IR; Qian, J; Busch, BB; Stevens, WC; Martin, R; Mohan, R; Zhou, SH; Ordentlich, P; Wei, P; Sapp, DW; Horlick, RA; Heyman, RA; Schulman, IG 分享 收藏 The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor β-dependent apoptosis in breast cancerRendi, MH; Suh, N; Lamph, WW; Krajewski, S; Reed, JC; Heyman, RA; Berchuck, A; Liby, K; Risingsong, R; Royce, DB; Williams, CR; Sporn, MB 分享 收藏 Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1cWatanabe, M; Houten, SM; Wang, L; Moschetta, A; Mangelsdorf, DJ; Heyman, RA; Moore, DD; Auwerx, J 分享 收藏 Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscleErrα 和Gabpa/b指定了糖尿病肌肉中pgc-1α 依赖性氧化磷酸化基因表达的改变Mootha, VK; Handschin, C; Arlow, D; Xie, XH; St Pierre, J; Sihag, S; Yang, WL; Altshuler, D; Puigserver, P; Patterson, N; Willy, PJ; Schulman, IG; Heyman, RA; Lander, ES; Spiegelman, BM 分享 收藏 分享 收藏 
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