未登录 Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening Woolford, Alison J. -A.; Pero, Joseph E.; Aravapalli, Sridhar; Berdini, Valerio; Coyle, Joseph E.; Day, Philip J.; Dodson, Andrew M.; Grondin, Pascal; Holding, Finn P.; Lee, Lydia Y. W.; Li, Peng; Manas, Eric S.; Marino, Joseph, Jr.; Martin, Agnes C. L.; McCleland, Brent W.; McMenamin, Rachel L.; Murray, Christopher W.; Neipp, Christopher E.; Page, Lee W.; Patel, Vipulkumar K.; Potvain, Florent; Rich, Sharna; Rivero, Ralph A.; Smith, Kirsten; Somers, Donald O.; Trottet, Lionel; Velagaleti, Ranganadh; Williams, Glyn; Xie, Ren 分享 收藏
CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma Carlson, Heather A.; Smith, Richard D.; Damm-Ganamet, Kelly L.; Stuckey, Jeanne A.; Ahmed, Aqeel; Convery, Maire A.; Somers, Donald O.; Kranz, Michael; Elkins, Patricia A.; Cui, Guanglei; Peishoff, Catherine E.; Lambert, Millard H.; Dunbar, James B., Jr. 分享 收藏
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening Borthwick, Jennifer A.; Ancellin, Nicolas; Bertrand, Sophie M.; Bingham, Ryan P.; Carter, Paul S.; Chun, Chun-wa; Churcher, Ian; Dodic, Nerina; Fournier, Charlene; Francis, Peter L.; Hobbs, Andrew; Jamieson, Craig; Pickett, Stephen D.; Smith, Sarah E.; Somers, Donald O'N.; Spitzfaden, Claus; Suckling, Colin J.; Young, Robert J. 分享 收藏
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors Deng, Hongfeng; Zhou, Jingye; Sundersingh, Flora; Messer, Jeffrey A.; Somers, Donald O.; Ajakane, Myriam; Arico-Muendel, Christopher C.; Beljean, Arthur; Belyanskaya, Svetlana L.; Bingham, Ryan; Blazensky, Emily; Boullay, Anne-Benedicte; Boursier, Eric; Chai, Jing; Carter, Paul; Chung, Chun-Wa; Daugan, Alain; Ding, Yun; Herry, Kenny; Hobbs, Clare; Humphries, Eric; Kollmann, Christopher; Van Loc Nguyen; Nicodeme, Edwige; Smith, Sarah E.; Dodic, Nerina; Ancellin, Nicolas 分享 收藏
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits Bertrand, Sophie M.; Ancellin, Nicolas; Beaufils, Benjamin; Bingham, Ryan P.; Borthwick, Jennifer A.; Boullay, Anne-Benedicte; Boursier, Eric; Carter, Paul S.; Chung, Chun-wa; Churcher, Ian; Dodic, Nerina; Fouchet, Marie-Helene; Foumier, Charlene; Francis, Peter L.; Gummer, Laura A.; Herry, Kenny; Hobbs, Andrew; Hobbs, Clare I.; Homes, Paul; Jamieson, Craig; Nicodeme, Edwige; Pickettlt, Stephen D.; Reid, Fain H.; Simpson, Graham L.; Sloan, Lisa A.; Smith, Sarah E.; Somers, Donald O'N.; Spitzfaden, Claus; Suckling, Cohn J.; Valko, Kara; Washio, Yoshiaki; Young, Robert J. 分享 收藏
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy Alder, Catherine M.; Ambler, Martin; Campbell, Amanda J.; Champigny, Aurelie C.; Deakin, Angela M.; Harling, John D.; Harris, Carol A.; Longstaff, Tim; Lynn, Sean; Maxwell, Aoife C.; Mooney, Chris J.; Scullion, Callum; Singh, Onkar M. P.; Smith, Ian E. D.; Somers, Donald O.; Tame, Christopher J.; Wayne, Gareth; Wilson, Caroline; Woolven, James M. 分享 收藏
p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression Aston, Nicola M.; Bamborough, Paul; Buckton, Jacqueline B.; Edwards, Christopher D.; Holmes, Duncan S.; Jones, Katherine L.; Patel, Vipulkumar K.; Smee, Penny A.; Somers, Donald O.; Vitulli, Giovanni; Walker, Ann L. 分享 收藏
Pyrrolidine-5,5-trans-lactams.: 4.: Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease Slater, MJ; Amphlett, EM; Andrews, DM; Bamborough, P; Carey, SJ; Johnson, MR; Jones, PS; Mills, G; Parry, NR; Somers, DO; Stewart, AJ; Skarzynski, T 分享 收藏
Pyrrolidine-5,5-trans-lactams.: 2.: The use of X-ray crystal structure data in the optimization of P3 and P4 substituents Andrews, DM; Chaignot, H; Coomber, BA; Good, AC; Hind, SL; Johnson, MR; Jones, PS; Mills, G; Robinson, JE; Skarzynski, T; Slater, MJ; Somers, DO 分享 收藏
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