Phillip A. Furman - Publications, H-index & Citations

Phillip A. Furman

Gilead Sciences

38H指数

125论文数

6.6K被引数

收录论文 30

发表时间

Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase (vol 55, pg 2481, 2012)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-03-24

PREAI

Sofia, Michael J.; Chang, Wonsuk; Furman, Phillip A.; Mosley, Ralph T.; Ross, Bruce S.

Editorial overview: Anti-infectives

CURRENT OPINION IN PHARMACOLOGY

IF4.2

2016-10-01

OAAI

Furman, Phillip; Sofia, Michael J.

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2014-11-01

OAAI

Lam, Angela M.; Edwards, Thomas E.; Mosley, Ralph T.; Murakami, Eisuke; Bansal, Shalini; Lugo, Christopher; Bao, Haiying; Otto, Michael J.; Sofia, Michael J.; Furman, Phillip A.

Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-01-29

PREAI

Kakarla, Ramesh; Liu, Jian; Naduthambi, Devan; Chang, Wonsuk; Mosley, Ralph T.; Bao, Donghui; Steuer, Holly-M. Micolochick; Keilman, Meg; Bansal, Shalini; Lam, Angela M.; Seibel, William; Neilson, Sandra; Furman, Phillip A.; Sofia, Michael J.

Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine (vol 57, pg 4181, 2013)

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2013-11-01

OAAI

Jones, Scott A.; Murakami, Eisuke; Delaney, William; Furman, Phillip; Hu, Jianming

Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-10-18

PREAI

Du, Jinfa; Chun, Byoung-Kwon; Mosley, Ralph T.; Bansal, Shalini; Bao, Haiying; Espiritu, Christine; Lam, Angela M.; Murakami, Eisuke; Niu, Congrong; Steuer, Holly M. Micolochick; Furman, Phillip A.; Sofia, Michael J.

Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2013-09-01

OAAI

Jones, Scott A.; Murakami, Eisuke; Delaney, William; Furman, Phillip; Hu, Jianming

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2012-07-01

OAAI

Niu, Congrong; Tolstykh, Tatiana; Bao, Haiying; Park, Yeojin; Babusis, Darius; Lam, Angela M.; Bansal, Shalini; Du, Jinfa; Chang, Wonsuk; Reddy, P. Ganapati; Zhang, Hai-Ren; Woolley, Joseph; Wang, Li-Quan; Chao, Piyun B.; Ray, Adrian S.; Otto, Michael J.; Sofia, Michael J.; Furman, Phillip A.; Murakami, Eisuke

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2012-06-01

226

OAAI

Lam, Angela M.; Espiritu, Christine; Bansal, Shalini; Steuer, Holly M. Micolochick; Niu, Congrong; Zennou, Veronique; Keilman, Meg; Zhu, Yuao; Lan, Shuiyun; Otto, Michael J.; Furman, Phillip A.

Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-01-23

288

PREAI

Sofia, Michael J.; Chang, Wonsuk; Furman, Phillip A.; Mosley, Ralph T.; Ross, Bruce S.

Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

JOURNAL OF VIROLOGY

IF3.8

2011-12-01

OAAI

Lam, Angela M.; Espiritu, Christine; Bansal, Shalini; Steuer, Holly M. Micolochick; Zennou, Veronique; Otto, Michael J.; Furman, Phillip A.

Adenosine Deaminase-like Protein 1 (ADAL1): Characterization and Substrate Specificity in the Hydrolysis of N6- or O6-Substituted Purine or 2-Aminopurine Nucleoside Monophosphates 腺苷脱氨酶样蛋白1 (ADAL1): N6-或O6-Substituted嘌呤或2-氨基嘌呤核苷单磷酸水解的表征和底物特异性

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-07-22

PREAI

Murakami, Eisuke; Bao, Haiying; Mosley, Ralph T.; Du, Jinfa; Sofia, Michael J.; Furman, Phillip A.

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-D-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2011-06-01

OAAI

Lam, Angela M.; Espiritu, Christine; Murakami, Eisuke; Zennou, Veronique; Bansal, Shalini; Steuer, Holly M. Micolochick; Niu, Congrong; Keilman, Meg; Bao, Haiying; Bourne, Nigel; Veselenak, Ronald L.; Reddy, P. Ganapati; Chang, Wonsuk; Du, Jinfa; Nagarathnam, Dhanapalan; Sofia, Michael J.; Otto, Michael J.; Furman, Phillip A.

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2010-12-17

OAAI

Chang, Wonsuk; Bao, Donghui; Chun, Byoung-Kwon; Naduthambi, Devan; Nagarathnam, Dhanapalan; Rachakonda, Suguna; Reddy, P. Ganapati; Ross, Bruce S.; Zhang, Hai-Ren; Bansal, Shalini; Espiritu, Christine L.; Keilman, Meg; Lam, Angela M.; Niu, Congrong; Steuer, Holly Micolochick; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J.

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2010-11-01

323

OAAI

Murakami, Eisuke; Tolstykh, Tatiana; Bao, Haiying; Niu, Congrong; Steuer, Holly M. Micolochick; Bao, Donghui; Chang, Wonsuk; Espiritu, Christine; Bansal, Shalini; Lam, Angela M.; Otto, Michael J.; Sofia, Michael J.; Furman, Phillip A.

Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-09-16

663

PREAI

Sofia, Michael J.; Bao, Donghui; Chang, Wonsuk; Du, Jinfa; Nagarathnam, Dhanapalan; Rachakonda, Suguna; Reddy, P. Ganapati; Ross, Bruce S.; Wang, Peiyuan; Zhang, Hai-Ren; Bansal, Shalini; Espiritu, Christine; Keilman, Meg; Lam, Angela M.; Steuer, Holly M. Micolochick; Niu, Congrong; Otto, Michael J.; Furman, Phillip A.

PSI-7851, a Pronucleotide of β-D-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2010-08-01

150

OAAI

Lam, Angela M.; Murakami, Eisuke; Espiritu, Christine; Steuer, Holly M. Micolochick; Niu, Congrong; Keilman, Meg; Bao, Haiying; Zennou, Veronique; Bourne, Nigel; Julander, Justin G.; Morrey, John D.; Smee, Donald F.; Frick, David N.; Heck, Julie A.; Wang, Peiyuan; Nagarathnam, Dhanapalan; Ross, Bruce S.; Sofia, Michael J.; Otto, Michael J.; Furman, Phillip A.

Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends

FUTURE MEDICINAL CHEMISTRY

IF3.4

2009-11-13

PREAI

Furman, Phillip A.; Lam, Angela M.; Murakami, Eisuke

The mechanism of action of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidme involves a second metabolic pathway leading to β-D-2'-deoxy-2-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2008-02-01

136

OAAI

Murakami, Eisuke; Niu, Congrong; Bao, Haiying; Steuer, Holly M. Micolochick; Whitaker, Tony; Nachman, Tammy; Sofia, Michael A.; Wang, Peiyuan; Otto, Michael J.; Furman, Phillip A.

Mechanism of activation of β-D-2′-deoxy-2′-fluoro-2′-C-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2007-02-01

157

OAAI

Murakami, Eisuke; Bao, Haiying; Ramesh, Mangala; McBrayer, Tamara R.; Whitaker, Tony; Steuer, Holly M. Micolochick; Schinazi, Raymond F.; Stuyver, Lieven J.; Obikhod, Aleksandr; Otto, Michael J.; Furman, Phillip A.

研究方向