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ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells ISB 2001三特异性T细胞接合器显示出强烈的肿瘤细胞毒性并克服了多发性骨髓瘤细胞的免疫逃逸机制 Carretero-Iglesia, Laura; Hall, Olivia J.; Berret, Jeremy; Pais, Daniela; Estoppey, Carole; Chimen, Myriam; Monney, Thierry; Loyau, Jeremy; Dreyfus, Cyrille; Macoin, Julie; Perez, Cynthia; Menon, Vinu; Gruber, Isabelle; Laurendon, Amelie; Caro, Lydia N.; Gudi, Girish S.; Matsuura, Tomomi; van der Graaf, Piet H.; Blein, Stanislas; Mbow, M. Lamine; Croasdale-Wood, Rebecca; Srivastava, Ankita; Dyson, Michael R.; Matthes, Thomas; Kaya, Zeynep; Edwards, Claire M.; Edwards, James R.; Maiga, Sophie; Pellat-Deceunynck, Catherine; Touzeau, Cyrille; Moreau, Philippe; Konto, Cyril; Drake, Adam; Zhukovsky, Eugene A.; Perro, Mario; Pihlgren, Maria 分享 收藏
Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma Grandclement, C.; Estoppey, C.; Dheilly, E.; Panagopoulou, M.; Monney, T.; Dreyfus, C.; Loyau, J.; Labanca, V.; Drake, A.; De Angelis, S.; Rubod, A.; Frei, J.; Caro, L. N.; Blein, S.; Martini, E.; Chimen, M.; Matthes, T.; Kaya, Z.; Edwards, C. M.; Edwards, J. R.; Menoret, E.; Kervoelen, C.; Pellat-Deceunynck, C.; Moreau, P.; Mbow, M. L.; Srivastava, A.; Dyson, M. R.; Zhukovsky, E. A.; Perro, M.; Sammicheli, S. 分享 收藏
Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies T细胞恶性肿瘤中靶向TRBC1和TRBC2的免疫疗法的结构指导工程 Ferrari, Mathieu; Righi, Matteo; Baldan, Vania; Wawrzyniecka, Patrycja; Bulek, Anna; Kinna, Alexander; Ma, Biao; Bughda, Reyisa; Akbar, Zulaikha; Srivastava, Saket; Gannon, Isaac; Robson, Mathew; Sillibourne, James; Jha, Ram; El-Kholy, Mohamed; Amin, Oliver Muhammad; Kokalaki, Evangelia; Banani, Mohammed Amin; Hussain, Rehan; Day, William; Lim, Wen Chean; Ghongane, Priyanka; Hopkins, Jade R.; Jungherz, Dennis; Herling, Marco; Welin, Martin; Surade, Sachin; Dyson, Michael; Mccafferty, John; Logan, Derek; Cordoba, Shaun; Thomas, Simon; Sewell, Andrew; Maciocia, Paul; Onuoha, Shimobi; Pule, Martin 分享 收藏
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Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries Dyson, Michael R.; Masters, Edward; Pazeraitis, Deividas; Perera, Rajika L.; Syrjanen, Johanna L.; Surade, Sachin; Thorsteinson, Nels; Parthiban, Kothai; Jones, Philip C.; Sattar, Maheen; Wozniak-Knopp, Gordana; Rueker, Florian; Leah, Rachael; McCafferty, John 分享 收藏
A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing Parthiban, Kothai; Perera, Rajika L.; Sattar, Maheen; Huang, Yanchao; Mayle, Sophie; Masters, Edward; Griffiths, Daniel; Surade, Sachin; Leah, Rachael; Dyson, Michael R.; McCafferty, John 分享 收藏
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Application of phage display to high throughput antibody generation and characterization Schofield, Darren J.; Pope, Anthony R.; Clementel, Veronica; Buckell, Jenny; Chapple, Susan D. J.; Clarke, Kay F.; Conquer, Jennie S.; Crofts, Anna M.; Crowther, Sandra R. E.; Dyson, Michael R.; Flack, Gillian; Griffin, Gareth J.; Hooks, Yvette; Howat, William J.; Kolb-Kokocinski, Anja; Kunze, Susan; Martin, Cecile D.; Maslen, Gareth L.; Mitchell, Joanne N.; O'Sullivan, Maureen; Perera, Rajika L.; Roake, Wendy; Shadbolt, S. Paul; Vincent, Karen J.; Warford, Anthony; Wilson, Wendy E.; Xie, Jane; Young, Joyce L.; McCafferty, John 分享 收藏
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