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W

Wendy Lee

Genentech
H指数:13
被引数:1,065

个人简介

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教育背景

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工作经历

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荣誉奖项

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Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model

共价泛TEAD抑制剂阻断YAP活性，并在Hippo依赖性癌症模型中表现出脑渗透性

Nature Communications
IF15.7
2026-06-270
OAAI
Thijs J. Hagenbeek; Jason Zbieg; Russell Smith; Sayantanee Paul; Luca Gerosa; Consuelo Torrini; Alissa D. Guarnaccia; Christy Ong; Jennifer A. Lacap; Miaoran Ning; Nicole M. Sodir; Marc Hafner; Julien Tremblay; James Hawley; Bryan Chan; Vishal A. Verma; Ramsay E. Beveridge; Peter L. Hsu; Gözde Ulas; Lisha Wang; Jim Nonomiya; Shu Chen; Victoria Pham; Joshua Webster; Jessica Preston; Jeff Hung; Jeff Eastham; Debra Dunlap; Wendy Lee; Paul Beroza; Naema Nayyar; Scott Martin; Eva Lin; Julie Weng; Scott A. Foster; Frances Shanahan; Rina Fong; Gladys Boenig; Paola Di Lello; Marta H. Kubala; Thomas Hunsaker; Mirunalini Ravichandran; Pablo Saenz-Lopez Larrocha; Jeffrey Lau; Le An; Elizabeth Levy; Maria N. Lorenzo; Jennie R. Lill; Zora D. Modrusan; Yi-Chen Chen; Xiaosai Yao; Priscilla K. Brastianos; Danilo Maddalo; Anwesha Dey
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

变构泛TEAD抑制剂阻断致癌YAP/TAZ信号传导并克服KRAS G12C抑制剂抗性

NATURE CANCER
IF28.5
2023-06-0562
OAAI
Hagenbeek, Thijs J. J.; Zbieg, Jason R. R.; Hafner, Marc; Mroue, Rana; Lacap, Jennifer A. A.; Sodir, Nicole M. M.; Noland, Cameron L. L.; Afghani, Shervin; Kishore, Ayush; Bhat, Kamakoti P. P.; Yao, Xiaosai; Schmidt, Stephen; Clausen, Saundra; Steffek, Micah; Lee, Wendy; Beroza, Paul; Martin, Scott; Lin, Eva; Fong, Rina; Di Lello, Paola; Kubala, Marta H. H.; Yang, Michelle N. -Y.; Lau, Jeffrey T. T.; Chan, Emily; Arrazate, Alfonso; An, Le; Levy, Elizabeth; Lorenzo, Maria N. N.; Lee, Ho-June; Pham, Trang H. H.; Modrusan, Zora; Zang, Richard; Chen, Yi-Chen; Kabza, Michal; Ahmed, Musaddeque; Li, Jason; Chang, Matthew T. T.; Maddalo, Danilo; Evangelista, Marie; Ye, Xin; Crawford, James J. J.; Dey, Anwesha
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling
CELL REPORTS
IF6.9
2020-06-0198
OAAI
Holden, Jeffrey K.; Crawford, James J.; Noland, Cameron L.; Schmidt, Stephen; Zbieg, Jason R.; Lacap, Jennifer A.; Zang, Richard; Miller, Gregory M.; Zhang, Yue; Beroza, Paul; Reja, Rohit; Lee, Wendy; Tom, Jeffrey Y. K.; Fong, Rina; Steffek, Micah; Clausen, Saundra; Hagenbeek, Thjis J.; Hu, Taishan; Zhou, Zheng; Shen, Hong C.; Cunningham, Christian N.
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-02-19211
OAAI
Crawford, James J. y; Johnson, Adam R.; Misner, Dinah L.; Belmont, Lisa D.; Castanedo, Georgette; Choy, Regina; Coraggio, Melis; Doug, Liming; Eigenbrot, Charles; Erickson, Rebecca; Ghilardi, Nico; Hau, Jonathan; Katewa, Arna; Kohli, Pawan Bir; Lee, Wendy; Lubach, Joseph W.; McKenzie, Brent S.; Ortwine, Daniel F.; Schutt, Leah; Tay, Suzanne; Wei, BinQing; Reif, Karin; Liu, Lichuan; Wong, Harvey; Young, Wendy B.
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-05-2455
PREAI
Rudolph, Joachim; Murray, Lesley J.; Ndubaku, Chudi O.; O'Brien, Thomas; Blackwood, Elizabeth; Wang, Weiru; Aliagas, Ignacio; Gazzard, Lewis; Crawford, James J.; Drobnick, Joy; Lee, Wendy; Zhao, Xianrui; Hoeflich, Klaus P.; Favor, David A.; Dong, Ping; Zhang, Haiming; Heise, Christopher E.; Oh, Angela; Ong, Christy C.; La, Hank; Chakravarty, Paroma; Chan, Connie; Jakubiak, Diana; Epler, Jennifer; Ramaswamy, Sreemathy; Vega, Roxanne; Cain, Gary; Diaz, Dolores; Zhong, Yu
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2015-11-0372
OAAI
Ndubaku, Chudi O.; Crawford, James J.; Drobnick, Joy; Aliagas, Ignacio; Campbell, David; Dong, Ping; Dornan, Laura M.; Duron, Sergio; Epler, Jennifer; Gazzard, Lewis; Heise, Christopher E.; Hoeflich, Klaus P.; Jakubiak, Diana; La, Hank; Lee, Wendy; Lin, Baiwei; Lyssikatos, Joseph P.; Maksimoska, Jasna; Marmorstein, Ronen; Murray, Lesley J.; O'Brien, Thomas; Oh, Angela; Ramaswamy, Sreemathy; Wang, Weiru; Zhao, Xianrui; Zhong, Yu; Blackwood, Elizabeth; Rudolph, Joachim
Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

利用pre-dfg残基Thr-406在氨基吡唑型PAK1抑制剂系列中获得高激酶选择性

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2015-05-2215
OAAI
Rudolph, Joachim; Aliagas, Ignacio; Crawford, James J.; Mathieu, Simon; Lee, Wendy; Chao, Qi; Dong, Ping; Rouge, Lionel; Wang, Weiru; Heise, Christopher; Murray, Lesley J.; La, Hank; Liu, Yanzhou; Manning, Gerard; Diederich, Francois; Hoeflich, Klaus P.

研究方向

暂未获取到该数据
J
James J. Crawford
H 指数:41论文数:161被引数:6,313
J
Joachim Rudolph
H 指数:37论文数:169被引数:4,936
L
Lesley Murray
H 指数:43论文数:184被引数:9,914
W
Weiru Wang
H 指数:42论文数:168被引数:1.0万
K
Klaus P. Hoeflich
H 指数:47论文数:267被引数:1.1万
I
Ignacio Aliagas
H 指数:18论文数:32被引数:2,395
H
Hank La
H 指数:25论文数:128被引数:2,292
C
Christopher E. Heise
H 指数:29论文数:86被引数:5,587
P
Paul Beroza
H 指数:26论文数:52被引数:2,588
S
Sreemathy Ramaswamy
H 指数:10论文数:21被引数:453