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J

James J. Crawford

Altos Labs
H指数:41
被引数:6,313

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荣誉奖项

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Allosteric disordering of eIF2B regulates the integrated stress response

eIF2B的别构失序调控整合应激反应

Nature Chemical Biology
IF13.7
2026-06-290
OAAI
Udit Dalwadi; Advait Subramanian; Aniliese Deal; Julia E. Conrad; Tamara Nadjsombati; Meera Venkatesh; Morgane Boone; Pascal F. Egea; Lingjie He; Nimit Jain; D. John Lee; Yuwei Liu; Lucas C. Reineke; Kazuki Saito; Nathaniel Talledge; Hannah Toutkoushian; Maxence Le Vasseur; Francesca Zappa; Raoul J. de Groot; Diego Acosta-Alvear; Christopher P. Arthur; Jodi Nunnari; Susan Marqusee; Rosalie E. Lawrence; Mauro Costa-Mattioli; James J. Crawford; Frank J. M. van Kuppeveld; Tristan I. Croll; Peter Walter; Adam Frost
Lipid Tales: Optimizing Arylomycin Membrane Anchors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-10-113
PRE
Koehler, Michael F. T.; Chen, Yi-Chen; Chen, Yongsheng; Chen, Yuan; Crawford, James J.; Durk, Matthew R.; Garland, Keira; Hanan, Emily J.; Higuchi, Robert I.; Hu, Huiyong; Ly, Cuong Q.; Paraselli, Prasuna G.; Roberts, Tucker C.; Schwarz, Jacob B.; Smith, Peter A.; Yu, Zhiyong; Heise, Christopher E.
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

变构泛TEAD抑制剂阻断致癌YAP/TAZ信号传导并克服KRAS G12C抑制剂抗性

NATURE CANCER
IF28.5
2023-06-0562
OAAI
Hagenbeek, Thijs J. J.; Zbieg, Jason R. R.; Hafner, Marc; Mroue, Rana; Lacap, Jennifer A. A.; Sodir, Nicole M. M.; Noland, Cameron L. L.; Afghani, Shervin; Kishore, Ayush; Bhat, Kamakoti P. P.; Yao, Xiaosai; Schmidt, Stephen; Clausen, Saundra; Steffek, Micah; Lee, Wendy; Beroza, Paul; Martin, Scott; Lin, Eva; Fong, Rina; Di Lello, Paola; Kubala, Marta H. H.; Yang, Michelle N. -Y.; Lau, Jeffrey T. T.; Chan, Emily; Arrazate, Alfonso; An, Le; Levy, Elizabeth; Lorenzo, Maria N. N.; Lee, Ho-June; Pham, Trang H. H.; Modrusan, Zora; Zang, Richard; Chen, Yi-Chen; Kabza, Michal; Ahmed, Musaddeque; Li, Jason; Chang, Matthew T. T.; Maddalo, Danilo; Evangelista, Marie; Ye, Xin; Crawford, James J. J.; Dey, Anwesha
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
SCIENCE SIGNALING
IF6.6
2020-06-0224
PREAI
Corzo, Cesar A.; Varfolomeev, Eugene; Setiadi, A. Francesca; Francis, Ross; Klabunde, Sha; Senger, Kate; Sujatha-Bhaskar, Swathi; Drobnick, Joy; Do, Steven; Suto, Eric; Huang, Zhiyu; Eastham-Anderson, Jeffrey; Katewa, Arna; Pang, Jodie; Domeyer, Melanie; Dela Cruz, Christopher; Paler-Martinez, Andres; Lau, Vivian W. C.; Hadadianpour, Azadeh; Ramirez-Carrozi, Vladimir; Sun, Yonglian; Bao, Katherine; Xu, Daqi; Hunley, Emily; Brightbill, Hans D.; Warming, Soren; Roose-Girma, Merone; Wong, Alfred; Tam, Lucinda; Emson, Claire L.; Crawford, James J.; Young, Wendy B.; Pappu, Rajita; McKenzie, Brent S.; Asghari, Vida; Vucic, Domagoj; Hackney, Jason A.; Austin, Cary D.; Lee, Wyne P.; Lekkerkerker, Annemarie; Ghilardi, Nico; Bryan, Marian C.; Kiefer, James R.; Townsend, Michael J.; Zarrin, Ali A.
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling
CELL REPORTS
IF6.9
2020-06-0198
OAAI
Holden, Jeffrey K.; Crawford, James J.; Noland, Cameron L.; Schmidt, Stephen; Zbieg, Jason R.; Lacap, Jennifer A.; Zang, Richard; Miller, Gregory M.; Zhang, Yue; Beroza, Paul; Reja, Rohit; Lee, Wendy; Tom, Jeffrey Y. K.; Fong, Rina; Steffek, Micah; Clausen, Saundra; Hagenbeek, Thjis J.; Hu, Taishan; Zhou, Zheng; Shen, Hong C.; Cunningham, Christian N.
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-06-2539
PREAI
Blaquiere, Nicole; Castanedo, Georgette M.; Burch, Jason D.; Berezhkovskiy, Leonid M.; Brightbill, Hans; Brown, Suzanne; Chan, Connie; Chiang, Po-Chang; Crawford, James J.; Dong, Teresa; Fan, Peter; Feng, Jianwen; Ghilardi, Nico; Godemann, Robert; Gogol, Emily; Grabbe, Alice; Hole, Alison J.; Hu, Baihua; Hymowitz, Sarah G.; Ismaili, Moulay Hicham Alaoui; Le, Hoa; Lee, Patrick; Lee, Wyne; Lin, Xingyu; Liu, Ning; McEwan, Paul A.; McKenzie, Brent; Silvestre, Hernani L.; Suto, Eric; Sujatha-Bhaskar, Swathi; Wu, Guosheng; Wu, Lawren C.; Zhang, Yamin; Zhong, Zoe; Staben, Steven T.

研究方向

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