未登录 分享 收藏
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity Wichroski, Michael; Benci, Joseph; Liu, Si-Qi; Chupak, Louis; Fang, Jie; Cao, Carolyn; Wang, Cindy; Onorato, Joelle; Qiu, Hongchen; Shan, Yongli; Banas, Dana; Powles, Ryan; Locke, Gregory; Witt, Abigail; Stromko, Caitlyn; Qi, Huilin; Zheng, Xiaofan; Martin, Scott; Ding, Min; Gentles, Robert; Meanwell, Nicholas; Velaparthi, Upender; Olson, Richard; Wee, Susan; Tenney, Daniel; Parker, Christopher G.; Cravatt, Benjamin F.; Lawrence, Michael; Borzilleri, Robert; Lees, Emma 分享 收藏
分享 收藏
分享 收藏
Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies Easton, Amy; Jensen, Marianne L.; Wang, Congwei; Hagedorn, Peter H.; Li, Yuwen; Weed, Michael; Meredith, Jere E.; Guss, Valerie; Jones, Kelli; Gill, Martin; Krause, Carol; Brown, Jeffrey M.; Hunihan, Lisa; Natale, Joanne; Fernandes, Alda; Lu, Yifeng; Polino, Joe; Bookbinder, Mark; Cadelina, Greg; Benitex, Yulia; Sane, Ramola; Morrison, John; Drexler, Dieter; Mercer, Stephen E.; Bon, Charlotte; Pandya, Nikhil J.; Jagasia, Ravi; Yang, Tai-Hsien Ou; Distler, Tania; Grueninger, Fiona; Meldgaard, Michael; Terrigno, Marco; Macor, John E.; Albright, Charles F.; Loy, James; Hoeg, Anja M.; Olson, Richard E.; Cacace, Angela M. 分享 收藏
Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features Hagedorn, Peter H.; Brown, Jeffrey M.; Easton, Amy; Pierdomenico, Maria; Jones, Kelli; Olson, Richard E.; Mercer, Stephen E.; Li, Dong; Loy, James; Hog, Anja M.; Jensen, Marianne L.; Gill, Martin; Cacace, Angela M. 分享 收藏
Preparations for a European R&D roadmap for an inertial fusion demo reactor 为惯性聚变演示反应堆的欧洲研发路线图做准备 Norreys, P. A.; Ceurvorst, L.; Sadler, J. D.; Spiers, B. T.; Aboushelbaya, R.; Mayr, M. W.; Paddock, R.; Ratan, N.; Savin, A. F.; Wang, R. H. W.; Glize, K.; Trines, R. M. G. M.; Bingham, R.; Hill, M. P.; Sircombe, N.; Ramsay, M.; Allan, P.; Hobbs, L.; James, S.; Skidmore, J.; Fyrth, J.; Luis, J.; Floyd, E.; Brown, C.; Haines, B. M.; Olson, R. E.; Yi, S. A.; Zylstra, A. B.; Flippo, K.; Bradley, P. A.; Peterson, R. R.; Kline, J. L.; Leeper, R. J. 分享 收藏
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides Anderson, Brian R.; Jensen, Marianne L.; Hagedorn, Peter H.; Little, Sean C.; Olson, Richard E.; Ammar, Ron; Kienzle, Bernadette; Thompson, John; McDonald, Ivar; Mercer, Stephen; Vikesaa, Jonas; Nordbo, Bettina; Iben, Larry; Cao, Yang; Natale, Joanne; Dalton-Kay, Greg; Cacace, Angela; Hansen, Bo R.; Hedtjarn, Maj; Koch, Troels; Bristow, Linda J. 分享 收藏
Observation of persistent species temperature separation in inertial confinement fusion mixtures Haines, Brian M.; Shah, R. C.; Smidt, J. M.; Albright, B. J.; Cardenas, T.; Douglas, M. R.; Forrest, C.; Glebov, V. Yu; Gunderson, M. A.; Hamilton, C. E.; Henderson, K. C.; Kim, Y.; Lee, M. N.; Murphy, T. J.; Oertel, J. A.; Olson, R. E.; Patterson, B. M.; Randolph, R. B.; Schmidt, D. W. 分享 收藏
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481 Boy, Kenneth M.; Guernon, Jason M.; Zuev, Dmitry S.; Xu, Li; Zhang, Yunhui; Shi, Jianliang; Marcin, Lawrence R.; Higgins, Mendi A.; Wu, Yong-Jin; Krishnananthan, Subramaniam; Li, Jianqing; Trehan, Ashok; Smith, Daniel; Toyn, Jeremy H.; Meredith, Jere E.; Burton, Catherine R.; Kimura, S. Roy; Zvyaga, Tatyana; Zhuo, Xiaoliang; Lentz, Kimberley A.; Grace, James E.; Denton, Rex; Morrison, John S.; Mathur, Arvind; Albright, Charles F.; Ahlijanian, Michael K.; Olson, Richard E.; Thompson, Lorin A.; Macor, John E. 分享 收藏
Process Optimization for the Large-Scale Preparation of (2S,3aR,7aS)-tert-Butyl Hexahydro-2,5-methanopyrrolo[3,2-c]pyridine-1(4H)-carboxylate, an Intermediate for Nicotinic Acetylcholine Receptor Agonists Jarugu, Lokesh Babu; Reddy, China Anki; Chikkananjunda, Nanjundaswamy Kanikahalli; Krishnamoorthy, Suresh; Sarvanakumar, Pon; Sankar, Ulaganathan; Arunachalam, Pirama Nayagam; McDonald, Ivar M.; Olson, Richard E.; Rampulla, Richard; Mathur, Arvind; Gupta, Anuradha 分享 收藏
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder Marcin, Lawrence R.; Warrier, Jayakumar; Thangathirupathy, Srinivasan; Shi, Jianliang; Karageorge, George N.; Pearce, Bradley C.; Ng, Alicia; Park, Hyunsoo; Kempson, James; Li, Jianqing; Zhang, Huiping; Mathur, Arvind; Reddy, Aliphedi B.; Nagaraju, G.; Tonukunuru, Gopikishan; Gupta, Grandhi V. R. K. M.; Kamble, Manjunatha; Mannoori, Raju; Cheruku, Srinivas; Jogi, Srinivas; Gulia, Jyoti; Bastia, Tanmaya; Sanmathi, Charulatha; Aher, Jayant; Kallem, Rajareddy; Srikumar, Bettadapura N.; Viaya, Kumar Kuchibhotla; Naidu, Pattipati S.; Paschapur, Mahesh; Kalidindi, Narasimharaju; Vikramadithyan, Reeba; Ramarao, Manjunath; Denton, Rex; Molski, Thaddeus; Shields, Eric; Subramanian, Murali; Zhuo, Xiaoliang; Nophsker, Michelle; Simmermacher, Jean; Sinz, Michael; Albright, Charlie; Bristow, Linda J.; Islam, Imadul; Bronson, Joanne J.; Olson, Richard E.; King, Dalton; Thompson, Lorin A.; Macor, John E. 分享 收藏
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning Weed, Michael R.; Polino, Joseph; Signor, Laura; Bookbinder, Mark; Keavy, Deborah; Benitex, Yulia; Morgan, Daniel G.; King, Dalton; Macor, John E.; Zaczek, Robert; Olson, Richard; Bristow, Linda J. 分享 收藏
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-D-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorders Bristow, Linda J.; Gulia, Jyoti; Weed, Michael R.; Srikumar, Bettadapura N.; Li, Yu-Wen; Graef, John D.; Naidu, Pattipati S.; Sanmathi, Charulatha; Aher, Jayant; Bastia, Tanmaya; Paschapur, Mahesh; Kalidindi, Narasimharaju; Kumar, Kuchibhotla Vijaya; Molski, Thaddeus; Pieschl, Rick; Fernandes, Alda; Brown, Jeffrey M.; Sivarao, Digavalli V.; Newberry, Kimberly; Bookbinder, Mark; Polino, Joseph; Keavy, Deborah; Newton, Amy; Shields, Eric; Simmermacher, Jean; Kempson, James; Li, Jianqing; Zhang, Huiping; Mathur, Arvind; Kallem, Raja Reddy; Sinha, Meenakshee; Ramarao, Manjunath; Vikramadithyan, Reeba K.; Thangathirupathy, Srinivasan; Warrier, Jayakumar; Islam, Imadul; Bronson, Joanne J.; Olson, Richard E.; Macor, John E.; Albright, Charlie F.; King, Dalton; Thompson, Lorin A.; Marcin, Lawrence R.; Sinz, Michael 分享 收藏
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators Robertson, Alan S.; Iben, Lawrence G.; Wei, Cong; Meredith, Jere E., Jr.; Drexler, Dieter M.; Banks, Martyn; Vite, Gregory D.; Olson, Richard E.; Thompson, Lorin A.; Albright, Charles F.; Ahlijanian, Michael K.; Toyn, Jeremy H. 分享 收藏
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation 发现非两性离子芳基磺酰胺作为Nav1.7抑制剂，在临床前行为模型和疼痛神经元激活的转化措施中具有功效 Wu, Yong-Jin; Guernon, Jason; McClure, Andrea; Luo, Guanglin; Rajamani, Ramkumar; Ng, Alicia; Easton, Amy; Newton, Amy; Bourin, Clotilde; Parker, Dawn; Mosure, Kathleen; Barnaby, Omar; Soars, Matthew G.; Knox, Ronald J.; Matchett, Michele; Pieschl, Rick; Herrington, James; Chen, Ping; Sivarao, D. V.; Bristow, Linda J.; Meanwell, Nicholas A.; Bronson, Joanne; Olson, Richard; Thompson, Lorin A.; Dzierba, Carolyn 分享 收藏
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents Pieschl, Rick L.; Miller, Regina; Jones, Kelli M.; Post-Munson, Debra J.; Chen, Ping; Newberry, Kimberly; Benitex, Yulia; Molski, Thaddeus; Morgan, Daniel; McDonald, Ivar M.; Macor, John E.; Olson, Richard E.; Asaka, Yukiko; Digavalli, Siva; Easton, Amy; Herrington, James; Westphal, Ryan S.; Lodge, Nicholas J.; Zaczek, Robert; Bristow, Linda J.; Li, Yu-Wen 分享 收藏
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain Wu, Yong-Jin; Guernon, Jason; Shi, Jianliang; Ditta, Jonathan; Robbins, Kevin J.; Rajamani, Ramkumar; Easton, Amy; Newton, Amy; Bourin, Clotilde; Mosure, Kathleen; Soars, Matthew G.; Knox, Ronald J.; Matchett, Michele; Pieschl, Rick L.; Post-Munson, Debra J.; Wang, Shuya; Herrington, James; Graef, John; Newberry, Kimberly; Bristow, Linda J.; Meanwell, Nicholas A.; Olson, Richard; Thompson, Lorin A.; Dzierba, Carolyn 分享 收藏
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor B-973，α7烟碱型乙酰胆碱受体的新型哌嗪正变构调节剂 Post-Munson, Debra J.; Pieschl, Rick L.; Molski, Thaddeus F.; Graef, John D.; Hendricson, Adam W.; Knox, Ronald J.; McDonald, Ivar M.; Olson, Richard E.; Macor, John E.; Weed, Michael R.; Bristow, Linda J.; Kiss, Laszlo; Ahlijanian, Michael K.; Herrington, James 分享 收藏
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
