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M

Marcellus Ubbink

leiden university

46H指数
265论文数
6.8K被引数
收录论文 85
发表时间
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Conserved Asp233–Asp246 hydrogen bond modulates active site dynamics in class A β-lactamases保守的Asp233–Asp246氢键调控A类β-内酰胺酶活性位点动力学
errProtein Science
IF5.2
err2026-09-18
err0
errOAAI
errCristina V. Lopez-Gallego; Monika Timmer; Jocelyne Vreede; Marcellus Ubbink
err分享
err收藏
Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid-resistant β-lactamase mutants磷酸盐离子调节两种克拉维酸抗性β-内酰胺酶突变体的酶活性和上位性效应。
errProtein Science
IF5.2
err2025-10-11
err0
errOAAI
errMarko Radojković; Saar F. Koene; Aleksandra Chikunova; Bogdan I. Florea; Sivanandam V. Natarajan; Aimee L. Boyle; Marcellus Ubbink
err分享
err收藏
Directed evolution of a beta-lactamase samples a wide variety of conformational statesβ-内酰胺酶的定向进化采样了广泛的构象状态
errProtein Science
IF5.2
err2025-10-11
err0
errOAAI
errJing Sun; Monika Timmer; Steffen Brünle; Aimee L. Boyle; Marcellus Ubbink
err分享
err收藏
A glycine at position 105 leads to clavulanic acid and avibactam resistance in class A β-lactamases105位的甘氨酸导致A类β-内酰胺酶对克拉维酸和阿维巴坦产生耐药性
errJournal of Biological Chemistry
IF3.9
err2025-06-06
err0
errOAAI
errMarko Radojković; Aleksandra Chikunova; Saar F. Koene; Monika Timmer; Sivanandam V. Natarajan; Aimee L. Boyle; Marcellus Ubbink
err分享
err收藏
The Nature of Nanodisc Lipids Influences Fragment-Based Drug Discovery Results
errCHEMICAL BIOLOGY & DRUG DESIGN
IF3.3
err2025-03-01
err0
errOAAI
errKnetsch, Tim G. J.; van Son, Henri; Kobayashi, Masakazu; Ubbink, Marcellus
err分享
err收藏
A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the β-lactamase BlaC (vol 278, 134665, 2024)
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2024-11-01
err0
PREAI
errSun, Jing; Boyle, Aimee L.; Bruenle, Steffen; Ubbink, Marcellus
err分享
err收藏
Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase (vol 250, 126160, 2023)
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2024-11-01
err0
PREAI
errSun, Jing; Chikunova, Aleksandra; Boyle, Aimee L.; Voskamp, Patrick; Timmer, Monika; Ubbink, Marcellus
err分享
err收藏
A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the (3-lactamase BlaC
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2024-10-01
err1
errOAAI
errSun, Jing; Boyle, Aimee L.; Brunle, Steffen; Ubbink, Marcellus
err分享
err收藏
Bimodal substrate binding in the active site of the glycosidase BcX
errFEBS JOURNAL
IF4.2
err2024-08-26
err1
errOAAI
errSaberi, Mahin; Chikunova, Aleksandra; Ben Bdira, Fredj; Cramer-Blok, Anneloes; Timmer, Monika; Voskamp, Patrick; Ubbink, Marcellus
err分享
err收藏
Positive epistasis drives clavulanic acid resistance in double mutant libraries of BlaC β-lactamase
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-02-17
err1
errOAAI
errRadojkovic, Marko; Ubbink, Marcellus
err分享
err收藏
Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2023-10-01
err5
errOAAI
errSun, Jing; Chikunova, Aleksandra; Boyle, Aimee L.; Voskamp, Patrick; Timmer, Monika; Ubbink, Marcellus
err分享
err收藏
Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis
errSCIENTIFIC REPORTS
IF3.9
err2023-09-16
err3
errOAAI
errvan Alen, Ilona; Garcia, Mayra A. Aguirre; Maaskant, Janneke J.; Kuijl, Coenraad P.; Bitter, Wilbert; Meijer, Annemarie H.; Ubbink, Marcellus
err分享
err收藏
Asp179 in the class A β-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis
errFEBS JOURNAL
IF4.2
err2023-07-02
err5
errOAAI
errvan Alen, Ilona; Chikunova, Aleksandra; van Zanten, Danny B.; de Block, Amber A.; Timmer, Monika; Brunle, Steffen; Ubbink, Marcellus
err分享
err收藏
Rigidified and Hydrophilic DOTA-like Lanthanoid Ligands: Design, Synthesis, and Dynamic Properties
errINORGANIC CHEMISTRY
IF4.7
err2023-02-17
err4
errOAAI
errMiao, Qing; Dekkers, Rene; Gupta, Karthick Babu Sai Sankar; Overhand, Mark; Dasgupta, Rubin; Ubbink, Marcellus
err分享
err收藏
Novel anti-repression mechanism of H-NS proteins by a phage protein
errNUCLEIC ACIDS RESEARCH
IF13.1
err2021-09-14
err7
errOAAI
errBen Bdira, Fredj; Erkelens, Amanda M.; Qin, Liang; Volkov, Alexander N.; Lippa, Andrew M.; Bowring, Nicholas; Boyle, Aimee L.; Ubbink, Marcellus; Dove, Simon L.; Dame, Remus T.
err分享
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Enhancing the population of the encounter complex affects protein complex formation efficiency
errFEBS JOURNAL
IF4.2
err2021-09-13
err0
errOAAI
errDi Savino, Antonella; Foerster, Johannes M.; Ullmann, G. Matthias; Ubbink, Marcellus
err分享
err收藏
Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2021-07-16
err8
errOAAI
errElings, Wouter; Chikunova, Aleksandra; van Zanten, Danny B.; Drenth, Ralphe; Ahmad, Misbha Ud Din; Blok, Anneloes J.; Timmer, Monika; Perrakis, Anastassis; Ubbink, Marcellus
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Conserved residues Glu37 and Trp229 play an essential role in protein folding of β-lactamase
errFEBS JOURNAL
IF4.2
err2021-05-02
err8
errOAAI
errChikunova, Aleksandra; Manley, Max P.; Ud Din Ahmad, Misbha; Bilman, Tugce; Perrakis, Anastassis; Ubbink, Marcellus
err分享
err收藏
A Two-Armed Probe for In-Cell DEER Measurements on Proteins (vol 26, pg 17128, 2020)用于对蛋白质进行细胞内鹿测量的双臂探针 (第26卷，17128页，2020)
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2021-03-26
err0
errOAAI
errMiao, Qing; Zurlo, Enrico; de Bruin, Donny; Wondergem, Joeri A. J.; Skinner, Simon P.; Timmer, Monika; Blok, Anneloes; Heinrich, Doris; Overhand, Mark; Huber, Martina; Ubbink, Marcellus
err分享
err收藏
A Two-Armed Probe for In-Cell DEER Measurements on Proteins**
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2020-11-17
err7
errOAAI
errMiao, Qing; Zurlo, Enrico; de Bruin, Donny; Wondergem, Joeri A. J.; Timmer, Monika; Blok, Anneloes; Heinrich, Doris; Overhand, Mark; Huber, Martina; Ubbink, Marcellus
err分享
err收藏

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