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J

Jonathan M. E. Hughes

Merck and Co. Inc.
H指数:16
被引数:1,125

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Biocatalytic Oxidative Desymmetrization of the Substituted Pyrrolidine Intermediate of MK-7845: An Investigational Antiviral Therapy for COVID-19

MK-7845的取代吡咯烷中间体的生物催化氧化不对称反应：一种用于COVID-19的探索性抗病毒疗法

Organic Process Research & Development
IF3.5
2026-03-110
PRE
Shorouk O. Badir; Yangzhong Qin; Michelle Zheng; David A. Vargas; Birgit Kosjek; Ajit Vikram; Anna L. Dunn; Michael Whittington; Yining Ji; Keith A. Mattern; Alex M. Confer; Jonathan M. E. Hughes; Reed T. Larson; Justin A. Newman; Nastaran Salehi Marzijarani; Nadine Kuhl; Jamie M. McCabe Dunn
Asymmetric Synthesis of KRAS G12C Inhibitor MK-1084 via a Crystallization-Induced Diastereomer Transformation (CIDT)

通过结晶诱导的非对映体转化 (CIDT) 不对称合成KRAS G12C抑制剂MK-1084

ORGANIC LETTERS
IF5
2026-01-010
PRE
Li, Hongming; Shang, Gao; Song, Zhiguo J.; Wen, Xin; Chen, Yonggang; Tan, Lushi; Xiao, Kai-Jiong; Xu, Jing; Sather, Aaron C.; Kong, Jongrock; Belyk, Kevin M.; Johnson, Heather C.; Hughes, Jonathan M. E.; Nawrat, Christopher C.; Kwan, Eugene E.; He, Cyndi Qixin; Lam, Yu-hong; Zhang, Jin; Fan, Chao; Song, Zhiyan; Liu, Guiquan; Wan, Baoqiang; Yuan, Yongpeng; Maddess, Matthew; Yin, Jingjun
Asymmetric Synthesis of MK-7845, an Investigational Treatment for COVID-19

MK-7845的不对称合成，新型冠状病毒肺炎的研究性治疗

ORGANIC LETTERS
IF5
2025-10-010
PRE
Larson, Reed T.; Turnbull, Ben W. H.; Moon, Patrick J.; Lehnherr, Dan; Hughes, Jonathan M. E.; Popov, Stasik; Brito, Gilmar A.; Andreani, Teresa; Kim, Suhong; Herbort, James; Sifri, Renee J.; Badir, Shorouk O.; Onyeagusi, Chibueze I.; Deprez, Nicholas R.; Otte, Douglas; Gauthier, Donald R.; Kuhl, Nadine; Ji, Yining; Neel, Andrew J.; Cohen, Ryan D.; Derrick, Jeffrey S.; Bottecchia, Cecilia; Hartmanshenn, Clara; Vargas, David A.; Dal Poggetto, Guilherme; Confer, Alex M.; Zheng, Michelle; Qin, Yangzhong; Vikram, Ajit; Newman, Justin A.; Sakhaei, Zeinab; Drout, Riki J.; Chen, Lu; Wu, Zheng; Castro, Steve; Betancourt, Stella K.; Longia, Gurpreet; Kassim, Brittany; Xu, Yingju; Dunn, Jamie M. McCabe; Marzijarani, Nastaran Salehi
Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-220
PRE
Skudlarek, Jason W.; Cooke, Andrew J.; Mitchell, Helen J.; Babaoglu, Kerim; Shaw, Anthony W.; Tong, Ling; Nomland, Ashley B.; Labroli, Marc; Sha, Deyou; Mulhearn, James J.; Wu, Chengwei; Li, Sarah W.; Beshore, Douglas C.; Hughes, Jonathan M. E.; Jouffroy, Matthieu; Wang, Hao; Balibar, Carl J.; Painter, Ronald E.; Shen, Pamela; Lange, Henry S.; Ishchenko, Andrii; Chen, Yun-Ting; Klein, Daniel J.; Tracy, Rodger W.; Miller, Randy R.; Cabalu, Tamara D.; Wu, Zhe; Leithead, Andrew; Scapin, Giovanna; Hruza, Alan W.; Dzhekieva, Liudmila; Bukhtiyarova, Marina; Homsher, Michelle F.; Xu, Min; Bahnck-Teets, Carolyn; McKenney, David; Buevich, Alexei V.; Liu, Jian; Zhang, Li-Kang; Meng, Tao; Kelly, Terri; Dinunzio, Edward; Soisson, Stephen; Cheng, Robert K. Y.; Hennig, Michael; Raheem, Izzat; Walker, Scott S.
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19
ORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
2024-06-062
PRE
Deprez, Nicholas R.; Hughes, Jonathan M. E.; Badir, Shorouk O.; Popov, Stasik; Andreani, Teresa; Bade, Rachel S.; Hartmanshenn, Clara; Kwok, Thomas Tai-min; Gauthier Jr, Donald R.; Marzijarani, Nastaran Salehi; Sakhaei, Zeinab; Drout, Riki; Castro, Steve; Schenk, David J.; Wolstenholme, Charles; Padivitage, Nilusha; Welch, Cody; Kowalski, Jason R.; Kassim, Brittany; Liu, Yong; Cohen, Ryan D.; Confer, Alex M.; Dal Poggetto, Guilherme; Brunskill, Andrew P. J.; Peng, Feng; Qi, Ji; Xu, Jing; Lin, Mingxiang; Dunn, Jamie M. McCabe
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-2320
PRE
Quiroz, Ryan, V; Reutershan, Michael H.; Schneider, Sebastian E.; Sloman, David; Lacey, Brian M.; Swalm, Brooke M.; Yeung, Charles S.; Gibeau, Craig; Spellman, Daniel S.; Rankic, Danica A.; Chen, Dapeng; Witter, David; Linn, Doug; Munsell, Erik; Feng, Guo; Xu, Haiyan; Hughes, Jonathan M. E.; Lim, Jongwon; Sauri, Josep; Geddes, Kristin; Wan, Murray; Mansueto, My Sam; Follmer, Nicole E.; Fier, Patrick S.; Siliphaivanh, Phieng; Daublain, Pierre; Palte, Rachel L.; Hayes, Robert P.; Lee, Sandra; Kawamura, Shuhei; Silverman, Steven; Sanyal, Sulagna; Henderson, Timothy J.; Ye, Yingchun; Gao, Yuanwei; Nicholson, Benjamin; Machacek, Michelle R.

研究方向

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R
Rohan R. Merchant
H 指数:28论文数:110被引数:3,245
T
Tian Qin
H 指数:38论文数:118被引数:6,338
J
Jet Tsien
H 指数:11论文数:51被引数:840
A
Alex M. Confer
H 指数:7论文数:32被引数:205
C
Clara Hartmanshenn
H 指数:9论文数:21被引数:981
N
Nastaran Salehi Marzijarani
H 指数:7论文数:17被引数:336
J
Jamie M. McCabe Dunn
H 指数:12论文数:46被引数:418
T
Teresa Andreani
H 指数:9论文数:37被引数:299
B
Byron K. Peters
H 指数:15论文数:54被引数:2,243
P
Patrick S. Fier
H 指数:26论文数:71被引数:3,309