Clara Hartmanshenn

merck & co., inc.

H指数:9

被引数:987

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Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide

生物催化级联实现大环肽enlicitide的制造

Science

IF45.8

2026-05-070

PRE

Artis Klapars; Anna Fryszkowska; Stephanie Galanie; Omer Ad; Ellen Y. Aguilera; Nnamdi Akporji; Chihui An; Stephanus Axnanda; Tewoderos M. Ayele; Richard S. Ayikpoe; Rodell C. Barrientos; Matthew R. Bauerle; Marc R. Becker; Kevin M. Belyk; Lisa Bereznitski; Jackson K. B. Cahn; Karla Camacho Soto; Louis-Charles Campeau; Kevin R. Campos; Anagha Chandra; Hsieh Yao Darryl Chang; Mengbin Chen; Zhiwei Chen; Wai Ling Cheung-Lee; Cheol K. Chung; Stephanie W. Chun; Sarah S. Co; Ryan D. Cohen; Stephen M. Dalby; Guilherme Dal Poggetto; Truc Do; Spencer D. Dreher; Riki J. Drout; Noah P. Dunham; Yi Fan; Ryan M. Flessner; Jacob H. Forstater; Scott P. France; Janaka C. Gamekkanda; Donald R. Gauthier; Agnieszka A. Gil; Jacob W. Greenwood; Noel Ha; Holst M. Halsey; Xinxin Han; Michael Hartmann; Clara Hartmanshenn; Yu He; Edgar Hernandez; Kaori Hiraga; Hsing-I Ho; Cynthia M. Hong; Alan Hruza; Hang Hu; Kari Hullen; Alan M. Hyde; Tetsuji Itoh; Chey M. Jones; Woo-Ok Jung; Kanan Kanuga; James Levi Knippel; Joshua N. Kolev; Jongrock Kong; Birgit Kosjek; Sara Koynov; Michael H. Kress; Bharath Krishnamurthi; Jeffrey T. Kuethe; Thomas T. Kwok; Alfred Y. Lee; Joshua Lee; Qiuhan Li; Shasha Li; Jing Liao; Wenjun Liu; Gurpreet Longia; Emma Madrigal; Peter E. Maligres; Kevin M. Maloney; Erin L. McCarthy; John A. McIntosh; Samaneh Mesbahi-Vasey; Margaret Miller; Mansi Modi; Jeffrey C. Moore; Debopreeti Mukherjee; Grant S. Murphy; Jennifer Victoriano Obligacion; Weilan Pan; Julia Parzecki; Anisha Patel; Teng Peng; Byron K. Peters; Tiffany Piou; Carlos A. Pons Siepermann; Christopher K. Prier; Akasha K. Purohit; Yangzhong Qin; Erik L. Regalado; Mikhail Reibarkh; Nelo R. Rivera; Sandra A. Robaire; Lee Robison; Syamantak Roy; Rebecca T. Ruck; Katie A. Rykaczewski; Christopher H. Schuster; Erica L. Schwalm; Andrew N. Singh; Eric Sirota; Alexandra C. Sun; Weijuan Tang; David A. Thaisrivongs; Nimisha Thakur; Weidong Tong; Van Truong; Ryan Tsoi; Qiang Tu; Ben W. H. Turnbull; Ophelia Ukaegbu; David A. Vargas; Juan E. Velasquez; Deeptak Verma; Heather Wang; Tao Wang; Xiao Wang; Ying Wang; Zhixun Wang; Matthew S. Winston; Chunyu Wu; Brian M. Wyvratt; Kai-Jiong Xiao; Yingju Xu; Jia-Xuan Yan; Hao Yang; Victoria Zhang; Yongqian Zhang; Michelle Zheng; Wendy Zhong

Asymmetric Synthesis of MK-7845, an Investigational Treatment for COVID-19

MK-7845的不对称合成，新型冠状病毒肺炎的研究性治疗

ORGANIC LETTERS

IF5

2025-10-010

PRE

Larson, Reed T.; Turnbull, Ben W. H.; Moon, Patrick J.; Lehnherr, Dan; Hughes, Jonathan M. E.; Popov, Stasik; Brito, Gilmar A.; Andreani, Teresa; Kim, Suhong; Herbort, James; Sifri, Renee J.; Badir, Shorouk O.; Onyeagusi, Chibueze I.; Deprez, Nicholas R.; Otte, Douglas; Gauthier, Donald R.; Kuhl, Nadine; Ji, Yining; Neel, Andrew J.; Cohen, Ryan D.; Derrick, Jeffrey S.; Bottecchia, Cecilia; Hartmanshenn, Clara; Vargas, David A.; Dal Poggetto, Guilherme; Confer, Alex M.; Zheng, Michelle; Qin, Yangzhong; Vikram, Ajit; Newman, Justin A.; Sakhaei, Zeinab; Drout, Riki J.; Chen, Lu; Wu, Zheng; Castro, Steve; Betancourt, Stella K.; Longia, Gurpreet; Kassim, Brittany; Xu, Yingju; Dunn, Jamie M. McCabe; Marzijarani, Nastaran Salehi

Total Synthesis of Enlicitide Decanoate

恩利西肽癸酸酯的全合成

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2025-03-243

PRE

Li, Hongming; Thaisrivongs, David A.; Shang, Gao; Chen, Yonggang; Chen, Qinghao; Tan, Lushi; Xiao, Kai-Jiong; Larson, Reed T.; Kuethe, Jeffrey T.; Lee, Joshua; Deprez, Nicholas R.; Nolting, Andrew F.; Poirier, Marc; Bulger, Paul G.; Regalado, Erik L.; Biba, Mirlinda; Tsay, Fuh-Rong; Dasilva, Jimmy; Prier, Chris K.; Strulson, Christopher A.; Zawatzky, Kerstin; Liu, Zhu; Newman, Justin A.; Sokolowsky, Kathleen; Tang, Weijuan; Hullen, Kari; Thakur, Nimisha; Welch, Cody; Patel, Smit; He, Yu; Xu, Jing; Variankaval, Narayan; Klapars, Artis; Kong, Jongrock; Desmond, Richard; Varsolona, Richard; Maligres, Peter E.; Siepermann, Carlos A. Pons; Robison, Lee; Piou, Tiffany; Hartmanshenn, Clara; Chandra, Anagha; Patel, Anisha; Becker, Marc R.; Liu, Guiquan; Duan, Jianjun; Wan, Baoqiang; Xiao, Chengqian; Yuan, Yongpeng; Cao, Xiaohui; Chen, Lu; Yi, Ruxia; Wu, Zheng; Feng, Minyi; Li, Donghong; Song, Zhiyan; Dong, Yawei; Sun, Julin; Li, Biao; Shao, Guangxin; Campeau, Louis-Charles; Yin, Jingjun

Attribute ranging as a coordinated strategy between drug substance and drug product to accelerate commercial process nomination

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2025-02-010

PRE

Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-06-062

PRE

Deprez, Nicholas R.; Hughes, Jonathan M. E.; Badir, Shorouk O.; Popov, Stasik; Andreani, Teresa; Bade, Rachel S.; Hartmanshenn, Clara; Kwok, Thomas Tai-min; Gauthier Jr, Donald R.; Marzijarani, Nastaran Salehi; Sakhaei, Zeinab; Drout, Riki; Castro, Steve; Schenk, David J.; Wolstenholme, Charles; Padivitage, Nilusha; Welch, Cody; Kowalski, Jason R.; Kassim, Brittany; Liu, Yong; Cohen, Ryan D.; Confer, Alex M.; Dal Poggetto, Guilherme; Brunskill, Andrew P. J.; Peng, Feng; Qi, Ji; Xu, Jing; Lin, Mingxiang; Dunn, Jamie M. McCabe

Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation-Lithiation as a Batch-Flow Process

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-05-090

PRE

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5-Chemoenzymatic Diastereoselective Fluorination/DKR

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-02-074

PRE

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6-Development of a Nucleophilic Aromatic Substitution in Water

ORGANIC PROCESS RESEARCH & DEVELOPMENT