Laura S. Itzhaki - Publications, H-index & Citations

Laura S. Itzhaki

university of cambridge

40H指数

213论文数

6.0K被引数

收录论文 67

发表时间

De novo grafted coiled-coil peptides as p53/hDM2 inhibitors 从头移植的螺旋-螺旋肽作为p53/hDM2抑制剂

rsc chem. biol.

IF0

2026-06-12

OAAI

Freya Spain; Diana Gimenez; Amanda M. Acevedo-Jake; Bram Mylemans; Nikolas J. Brooks; Boguslawa Korona; Danny T. Huang; Thomas A. Edwards; Aneika C. Leney; Laura Itzhaki; Derek N. Woolfson; Andrew J. Wilson

Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilizing Effects on the Scaffold PR65 小分子蛋白磷酸酶2A激活剂对支架PR65产生全局稳定效应

JACS Au

IF8.7

2026-04-20

OAAI

Mohsin M. Naqvi; Maria Zacharopoulou; Satyaki Saha; Anupam Banerjee; Sema Z. Yilmaz; Vanda Sunderlikova; Chris M. Johnson; Janet R. Kumita; Shang-Hua Yang; Reuven Gordon; Michael Ohlmeyer; Sander J. Tans; Mert Gur; Ivet Bahar; Laura S. Itzhaki

Small Molecule Activator of Phosphatase PP2A Remodels Scaffold PR65 Structural Dynamics To Promote Holoenzyme Assembly

JACS Au

IF8.7

2026-01-20

OAAI

Sema Z. Yilmaz; Anupam Banerjee; Satyaki Saha; Michael Ohlmeyer; Reuven Gordon; Laura S. Itzhaki; Ivet Bahar; Mert Gur

Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a 纳米抗体恢复了肿瘤抑制蛋白p16INK4a的癌症相关突变体的稳定性

Structure

IF4.3

2025-08-14

OAAI

Owen Burbidge; Martyna W. Pastok; Diana Papini; Samantha L. Hodder; Grasilda Zenkevičiūtė; Kenneth Z.J. Tan; Shannon Turberville; Martin E.M. Noble; Jane A. Endicott; Laura Itzhaki

Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils 使用稳定的蛋白质骨架展示与α-突触核蛋白纤维结合的肽段

PROTEIN SCIENCE

IF5.2

2025-05-15

OAAI

Bismut, Samuel; Schneider, Matthias M.; Miyasaki, Masashi; Feng, Yuqing; Wilde, Ellis J.; Gunawardena, M. Dylan; Knowles, Tuomas P. J.; Schierle, Gabrielle S. Kaminski; Itzhaki, Laura S.; Kumita, Janet R.

Nanoparticle-Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology 纳米颗粒介导的靶向蛋白降解：一种新兴的治疗技术

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2025-05-09

OAAI

Dr. Andrew G. Baker; Adrian Pui Ting Ho; Prof. Laura S. Itzhaki; Prof. Ljiljana Fruk

CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer CHD8 与 BCL11A 相互作用，以在 triple negative breast cancer（三阴性乳腺癌）中诱导癌基因转录。

EMBO JOURNAL

IF8.3

2025-05-06

OAAI

Waterhouse, Mark; Lazarus, Kyren; Santolla, Maria Francesca; Pensa, Sara; Williams, Eleanor; Siu, Abigail J. Q.; Mohammed, Hisham; Mohorianu, Irina; Maggiolini, Marcello; Carroll, Jason; Itzhaki, Laura S.; Rahman, Taufiq; Khaled, Walid T.

Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates 串联重复蛋白为工程生物分子凝聚体引入了可调谐的特性。

CHEMICAL SCIENCE

IF7.4

2025-01-01

OAAI

Ng, Tin Long Chris; Hoare, Mateo P.; Maristany, M. Julia; Wilde, Ellis J.; Sneideris, Tomas; Huertas, Jan; Agbetiameh, Belinda K.; Furukawa, Mona; Joseph, Jerelle A.; Knowles, Tuomas P. J.; Collepardo-Guevara, Rosana; Itzhaki, Laura S.; Kumita, Janet R.

How to target membrane proteins for degradation: Bringing GPCRs into the TPD fold

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-12-01

OAAI

Korona, Boguslawa; Itzhaki, Laura S.

Influence of point mutations on PR65 conformational adaptability: Insights from molecular simulations and nanoaperture optical tweezers

SCIENCE ADVANCES

IF12.5

2024-05-31

OAAI

Banerjee, Anupam; Mathew, Samuel; Naqvi, Mohsin M.; Yilmaz, Sema Z.; Zacharopoulou, Maria; Doruker, Pemra; Kumita, Janet R.; Yang, Shang-Hua; Gur, Mert; Itzhaki, Laura S.; Gordon, Reuven; Bahar, Ivet

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-05-13

OAAI

King, Harry R.; Bycroft, Mark; Nguyen, Thanh-Binh; Kelly, Geoff; Vinogradov, Alexander A.; Rowling, Pamela J. E.; Stott, Katherine; Ascher, David B.; Suga, Hiroaki; Itzhaki, Laura S.; Artavanis -Tsakonas, Katerina

Investigating the Interactions of the Cucumber Mosaic Virus 2b Protein with the Viral 1a Replicase Component and the Cellular RNA Silencing Factor Argonaute 1

VIRUSES-BASEL

IF3.5

2024-04-25

OAAI

Crawshaw, Sam; Murphy, Alex M.; Rowling, Pamela J. E.; Nietlispach, Daniel; Itzhaki, Laura S.; Carr, John P.

Tandem-repeat proteins conformational mechanics are optimized to facilitate functional interactions and complexations

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2024-02-01

OAAI

Ventura, Carlos; Banerjee, Anupam; Zacharopoulou, Maria; Itzhaki, Laura S.; Bahar, Ivet

Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution 红光调制的邻位 -氯偶氮苯光开关，用于肽装订通过芳族取代

RSC Chemical Biology

IF3.1

2024-01-01

OAAI

Kapun, Mia; Perez-Areales, F. Javier; Ashman, Nicola; Rowling, Pamela J. E.; Schober, Tim; Fowler, Elaine; Itzhaki, Laura S.; Spring, David R.

Counting Degrons: Lessons From Multivalent Substrates for Targeted Protein Degradation

FRONTIERS IN PHYSIOLOGY

IF3.4

2022-07-04

OAAI

Okoye, Cynthia N.; Rowling, Pamela J. E.; Itzhaki, Laura S.; Lindon, Catherine

Multivalent Interaction of Beta-Catenin With its Intrinsically Disordered Binding Partner Adenomatous Polyposis Coli

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2022-06-08

OAAI

Rowling, Pamela J. E.; Murton, Ben L.; Du, Zhen; Itzhaki, Laura S.

Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2022-05-09

OAAI

Wezen, Xavier Chee; Chandran, Aneesh; Eapen, Rohan Sakariah; Waters, Elaine; Bricio-Moreno, Laura; Tosi, Tommaso; Dolan, Stephen; Millership, Charlotte; Kadioglu, Aras; Grundling, Angelika; Itzhaki, Laura S.; Welch, Martin; Rahman, Taufiq

Micromechanics of soft materials using microfluidics

MRS BULLETIN

IF4.9

2022-04-11

OAAI

Xu, Yufan; Zhu, Hongjia; Shen, Yi; Guttenplan, Alexander P. M.; Saar, Kadi L.; Lu, Yuqian; Vigolo, Daniele; Itzhaki, Laura S.; Knowles, Tuomas P. J.

Unraveling the Mechanics of a Repeat-Protein Nanospring: From Folding of Individual Repeats to Fluctuations of the Superhelix

ACS NANO

IF16

2022-03-08

OAAI

Synakewicz, Marie; Eapen, Rohan S.; Perez-Riba, Albert; Rowling, Pamela J. E.; Bauer, Daniela; Weissl, Andreas; Fischer, Gerhard; Hyvonen, Marko; Rief, Matthias; Itzhaki, Laura S.; Stigler, Johannes

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity Α-突触核蛋白寡聚体中的病理性G51D突变赋予不同的结构属性和细胞毒性

MOLECULES

IF4.6

2022-02-15

OAAI

Xu, Catherine K.; Castellana-Cruz, Marta; Chen, Serene W.; Du, Zhen; Meisl, Georg; Levin, Aviad; Mannini, Benedetta; Itzhaki, Laura S.; Knowles, Tuomas P. J.; Dobson, Christopher M.; Cremades, Nunilo; Kumita, Janet R.

研究方向