Shane W. Krska - Publications, H-index & Citations

Shane W. Krska

merck & company

42H指数

162论文数

8.7K被引数

收录论文 68

发表时间

Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-09-12

PREAI

Tyagarajan, Sriram; Andrews, Christine L.; Beshore, Douglas C.; Buevich, Alexei V.; Curran, Patrick J.; Dandliker, Peter; Greshock, Thomas J.; Hoar, Jason; Kim, Alex; Karnachi, Prabha; Knemeyer, Ian; Kozlowski, Joseph; Liu, Jian; Maletic, Milana; Myers, Robert; Rada, Vanessa; Sha, Deyou; Sauvagnat, Berengere; Vachal, Petr; Wolkenberg, Scott; Yu, Wensheng; Yu, Younong; Krska, Shane W.

Radical chlorination of non-resonant heterobenzylic C - H bonds and high-throughput diversification of heterocycles

CHEM

IF19.6

2024-05-01

PREAI

Golden, Dung L.; Flynn, Kaitlyn M.; Aikonen, Santeri; Hanneman, Christopher M.; Kalyani, Dipannita; Krska, Shane W.; Paton, Robert S.; Stahl, Shannon S.

Development of High-Throughput Experimentation Approaches for Rapid Radiochemical Exploration

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-04-05

PREAI

Webb, E. William; Cheng, Kevin; Winton, Wade P.; Klein, Brandon J. C.; Bowden, Gregory D.; Horikawa, Mami; Liu, S. Wendy; Wright, Jay S.; Verhoog, Stefan; Kalyani, Dipannita; Wismer, Michael; Krska, Shane W.; Sanford, Melanie S.; Scott, Peter J. H.

Cu Oxamate-Promoted Cross-Coupling of α-Branched Amines and Complex Aryl Halides: Investigating Ligand Function through Data Science

ACS CATALYSIS

IF13.1

2023-12-05

PREAI

Matthews, Adrian D.; Peters, Ellyn; Debenham, John S.; Gao, Qi; Nyamiaka, Maya D.; Pan, Jianping; Zhang, Li-Kang; Dreher, Spencer D.; Krska, Shane W.; Sigman, Matthew S.; Uehling, Mycah R.

Copper-Catalyzed Benzylic C-H Cross-Coupling Enabled by Redox Buffers: Expanding Synthetic Access to Three-Dimensional Chemical Space

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2023-12-05

OAAI

Chen, Si-Jie; Krska, Shane W.; Stahl, Shannon S.

Polar Heterobenzylic C(sp3)-H Chlorination Pathway Enabling Efficient Diversification of Aromatic Nitrogen Heterocycles

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2023-08-29

OAAI

Maity, Soham; Lopez, Marco A.; Bates, Desiree M.; Lin, Shishi; Krska, Shane W.; Stahl, Shannon S.

A preparative small- molecule mimic of liver CYP450 enzymes in the aliphatic C-H oxidation of carbocyclic N-heterocycles

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-07-10

OAAI

Chambers, Rachel K.; Weaver, Jacob D.; Kim, Jinho; Hoar, Jason L.; Krska, Shane W.; White, M. Christina

Accessing three-dimensional molecular diversity through benzylic C-H cross-coupling

NATURE SYNTHESIS

IF20

2023-06-01

OAAI

Chen, Si-Jie; He, Cyndi Qixin; Kong, May; Wang, Jun; Lin, Shishi; Krska, Shane W.; Stahl, Shannon S.

Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions

BIOCONJUGATE CHEMISTRY

IF3.9

2023-02-14

PREAI

Cao, Wendy; Maza, Johnathan C.; Chernyak, Natalia; Flygare, John A.; Krska, Shane W.; Toste, F. Dean; Francis, Matthew B.

The Catalysis Laboratory at Merck: 20 Years of Catalyzing Innovation

ACS CATALYSIS

IF13.1

2022-12-20

OAAI

Ruck, Rebecca T.; Strotman, Neil A.; Krska, Shane W.

Merging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening 通过高通量树脂上反应筛选将后期多样化与固相肽合成相结合

ACS CATALYSIS

IF13.1

2022-02-23

PREAI

Li, Shasha; Pissarnitski, Dmitri; Nowak, Timothy; Wleklinski, Michael; Krska, Shane W.

Development of a high intensity parallel photoreactor for high throughput screening

REACTION CHEMISTRY & ENGINEERING

IF3.1

2022-01-01

PREAI

Qi, Ning; Wismer, Michael K.; Conway, Donald, V; Krska, Shane W.; Dreher, Spencer D.; Lin, Shishi

A Neophyl Palladacycle as an Air- and Thermally Stable Precursor to Oxidative Addition Complexes

ORGANIC LETTERS

IF5

2021-10-06

OAAI

King, Ryan P.; Krska, Shane W.; Buchwald, Stephen L.

Copper-Catalyzed Cross-Coupling of Benzylic C-H Bonds and Azoles with Controlled N-Site Selectivity 铜催化的苄基c-h键和吡咯的交叉偶联，具有受控的N位选择性

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-08-31

OAAI

Chen, Si-Jie; Golden, Dung L.; Krska, Shane W.; Stahl, Shannon S.

Chemistry Informer Libraries: Conception, Early Experience, and Role in the Future of Cheminformatics

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2021-03-16

PREAI

Dreher, Spencer D.; Krska, Shane W.

Synthesis of HDAC Inhibitor Libraries via Microscale Workflow

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-02-08

OAAI

Dykstra, Kevin D.; Streckfuss, Eric; Liu, Min; Liu, Jian; Yu, Younong; Wang, Ming; Kozlowski, Joseph A.; Myers, Robert W.; Buevich, Alexei, V; Maletic, Milana M.; Vachal, Petr; Krska, Shane W.

Benzylic C-H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas

CHEMICAL SCIENCE

IF7.4

2021-01-01

OAAI

Suh, Sung-Eun; Nkulu, Leah E.; Lin, Shishi; Krska, Shane W.; Stahl, Shannon S.

Highly Efficient Asymmetric Synthesis of Sitagliptin (vol 131, pg 8798, 2009)

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2020-07-24

PREAI

Hansen, Karl B.; Hsiao, Yi; Xu, Feng; Rivera, Nelo; Clausen, Andrew; Kubryk, Michele; Krska, Shane; Rosner, Thorsten; Simmons, Bryon; Balsells, Jaume; Ikemoto, Nori; Sun, Yongkui; Spindler, Felix; Malan, Christophe; Grabowski, Edward J. J.; Armstrong, Joseph D., III

Application of High-Throughput Competition Experiments in the Development of Aspartate-Directed Site-Selective Modification of Tyrosine Residues in Peptides

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2020-06-17

OAAI

Chinn, Alex J.; Hwang, Jaeyeon; Kim, Byoungmoo; Parish, Craig A.; Krska, Shane W.; Miller, Scott J.

Site-Selective Synthesis of Insulin Azides and Bioconjugates 胰岛素叠氮化物和生物缀合物的位点选择性合成

BIOCONJUGATE CHEMISTRY

IF3.9

2019-04-04

PREAI

Boga, Sobhana Babu; Krska, Shane W.; Lin, Songnian; Pissarnitski, Dmitri; Yan, Lin; Kekec, Ahmet; Tang, Weijuan; Pierson, Nicholas A.; Strulson, Christopher A.; Streckfuss, Eric; Zhu, Xiaohong; Zhang, Xiaoping; Kelly, Terri; Parish, Craig A.

研究方向