Steven J. Charlton - Publications, H-index & Citations

Steven J. Charlton

omass therapeutics

38H指数

129论文数

5.0K被引数

收录论文 66

发表时间

The Pharmacology of the SLC15A4-TASL Complex, an Emerging Target for the Treatment of Lupus SLC15A4-TASL复合物的药理学研究，一种治疗狼疮的新兴靶点

Pharmacology Research & Perspectives

IF2.3

2026-09-30

OAAI

Alex L. Wilkinson; Dillon Popat; Kathy Sengmany; Miguel C. Silva; Steven J. Charlton; Charles S. Lay

Explicit formulas for Grassmannian polylogarithms in weights 4 and 5 重数4和5的Grassmannian多对数函数的显式公式

JOURNAL OF NUMBER THEORY

IF0.7

2025-10-01

PREAI

Charlton, Steven; Gangl, Herbert; Radchenko, Danylo

Development of a BRET based chloride biosensor for high throughput screening of KCC2 modulators 基于BRET的氯离子生物传感器在KCC2调节剂的高通量筛选中的应用开发

SLAS Discovery

IF2.7

2025-06-24

OAAI

Charles S. Lay; Elvira Diamantopoulou; Katharina L. Dürr; Idlir Liko; Steven J. Charlton

Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting 32-adrenoceptor agonist, indacaterol, in human airway epithelial cells 卡巴胆碱（一种毒蕈碱受体激动剂）与长效32-肾上腺素受体激动剂indacaterol在人体气道上皮细胞中的基因组串扰

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-06-01

PREAI

Jayasinghe, Varuna; Joshi, Radhika; Joshi, Taruna; Paracha, Tamkeen U.; Kooi, Cora; Mostafa, Mahmoud M.; Bauer, Carla M. T.; Charlton, Steven J.; Iartchouk, Oleg; Maillet, Ashley; Morris, Melody K.; Ruda, Vera M.; Sandham, David A.; Wang, Yanqun; Newton, Robert; Giembycz, Mark A.

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor 鉴定多巴胺D2受体正位别构调节剂的脂质暴露外旋结合位点

ACS CHEMICAL NEUROSCIENCE

IF3.9

2025-05-15

PREAI

Lim, Herman D.; Bartuzi, Damian; Keen, Alastair C.; Rauffenbart, Caroline; Glenn, Jacqueline; Charlton, Steven J.; Lovera, Silvia; Sands, Zara A.; Ates, Ali; Wood, Martyn; Canals, Meritxell; Javitch, Jonathan A.; Carlsson, Jens; Lane, J. Robert

Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-07-31

OAAI

Casella, Bianca Maria; Farmer, James P. P.; Nesheva, Desislava N. N.; Williams, Huw E. L.; Charlton, Steven J. J.; Holliday, Nicholas D. D.; Laughton, Charles A. A.; Mistry, Shailesh N. N.

Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor

NATURE CHEMISTRY

IF20.2

2022-11-10

OAAI

Yen, Hsin-Yung; Liko, Idlir; Song, Wanling; Kapoor, Parth; Almeida, Fernando; Toporowska, Joanna; Gherbi, Karolina; Hopper, Jonathan T. S.; Charlton, Steven J.; Politis, Argyris; Sansom, Mark S. P.; Jazayeri, Ali; Robinson, Carol, V

Using NanoBit complementation and TR FRET to Study the Mechanism of Action of Small-molecule Modulators of CXCR2

FASEB JOURNAL

IF4.2

2020-04-21

OAAI

Nesheva, Desislava; Charlton, Steven; Mistry, Sheilesh; Holliday, Nicholas

Investigating the Kinetics of β1 and β2 Adrenoceptor Effector Recruitment using Luciferase Complementation Assays

FASEB JOURNAL

IF4.2

2020-04-21

OAAI

Dijon, Nicola; Holliday, Nicholas; Charlton, Steven

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-10-03

OAAI

Fyfe, Tim J.; Kellam, Barrie; Sykes, David A.; Capuano, Ben; Scammells, Peter J.; Lane, J. Robert; Charlton, Steven J.; Mistry, Shailesh N.

Investigating the Influence of Tracer Kinetics on Competition-Kinetic Association Binding Assays: Identifying the Optimal Conditions for Assessing the Kinetics of Low-Affinity Compounds

MOLECULAR PHARMACOLOGY

IF3

2019-09-01

OAAI

Sykes, David A.; Jain, Palash; Charlton, Steven J.

Profile of ARX001822, a highly potent, selective and orally bioavailable A2a antagonist effective in preventing adenosinergic suppression of T cell activation

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Finan, Peter M.; Pettipher, Roy; White, Jonathan; Patel, Viral; Moulton, Ben; Porres, Soraya; Gherbi, Karolina; Rosethorne, Elizabeth M.; Charlton, Steven J.; McCarthy, Clive

Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2019-05-01

OAAI

Koziczak-Holbro, Magdalena; Rigel, Dean F.; Dumotier, Berengere; Sykes, David A.; Tsao, Jeffrey; Ngoc-Hong Nguyen; Bosch, Julian; Jourdain, Marie; Flotte, Ludivine; Adachi, Yuichiro; Kiffe, Michael; Azria, Moise; Fairhurst, Robin A.; Charlton, Steven J.; Richardson, Brian P.; Lach-Trifilieff, Estelle; Glass, David J.; Ullrich, Thomas; Hatakeyama, Shinji

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

SCIENCE SIGNALING

IF6.6

2018-10-09

OAAI

Civciristov, Srgjan; Ellisdon, Andrew M.; Suderman, Ryan; Pon, Cindy K.; Evans, Bronwyn A.; Kleifeld, Oded; Charlton, Steven J.; Hlavacek, William S.; Canals, Meritxell; Halls, Michelle L.

Reply to 'Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects'

NATURE COMMUNICATIONS

IF15.7

2018-09-03

OAAI

Sykes, David A.; Lane, J. Robert; Szabo, Monika; Capuano, Ben; Javitch, Jonathan A.; Charlton, Steven J.

Biased Agonism in Drug Discovery-Is It Too Soon to Choose a Path?

MOLECULAR PHARMACOLOGY

IF3

2018-04-01

OAAI

Michel, Martin C.; Charlton, Steven J.

Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes

SCIENTIFIC REPORTS

IF3.9

2018-02-22

OAAI

Gherbi, Karolina; Briddon, Stephen J.; Charlton, Steven J.

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

NATURE COMMUNICATIONS

IF15.7

2017-10-02

161

OAAI

Sykes, David A.; Moore, Holly; Stott, Lisa; Holliday, Nicholas; Javitch, Jonathan A.; Lane, J. Robert; Charlton, Steven J.

Discovery of Fevipiprant (NVP-QAWO39), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma (vol 8, pg 582, 2017)

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2017-09-01

OAAI

Sandham, David A.; Barker, Lucy; Brown, Lyndon; Brown, Zarin; Budd, David; Charlton, Steven J.; Chatterjee, Devnandan; Cox, Brian; Dubois, Gerald; Duggan, Nicholas; Hall, Edward; Hatto, Julia; Leblanc, Catherine; Maas, Janet; Manini, Jodie; Profit, Rachael; Riddy, Darren; Ritchie, Catherine; Sohal, Bindi; Shaw, Duncan; Stringer, Rowan; Sykes, David A.; Thomas, Matthew; Turner, Katharine L.; Watson, Simon J.; West, Ryan; Willard, Elisabeth; Williams, Gareth; Willis, Jennifer

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2017-04-27

OAAI

Sandham, David A.; Barker, Lucy; Brown, Lyndon; Brown, Zarin; Budd, David; Charlton, Steven J.; Chatterjee, Devnandan; Cox, Brian; Dubois, Gerald; Duggan, Nicholas; Hall, Edward; Hatto, Julia; Maas, Janet; Manini, Jodie; Profit, Rachael; Riddy, Darren; Ritchie, Catherine; Sohal, Bindi; Shaw, Duncan; Stringer, Rowan; Sykes, David A.; Thomas, Matthew; Turner, Katharine L.; Watson, Simon J.; West, Ryan; Willard, Elisabeth; Williams, Gareth; Willis, Jennifer

研究方向