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J

J. Robert Lane

University of Nottingham

41H指数
138论文数
7.5K被引数
收录论文 90
发表时间
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The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology多巴胺D3受体与卡利拉赞结合的结构揭示了具有设计药理学特性的部分激动剂的原则
errScience Advances
IF12.5
err2026-08-28
err0
errOAAI
errEliane Hadas Yardeni; Dóra Judit Kiss; Julie Sanchez; Keshet Shavit; Dénes Szepesi Kovács; Attila Egyed; Caleb D. Vogt; Supriya A. Gaitonde; Jacqueline Glenn; Meritxell Canals; Michel Bouvier; Amy Hauck Newman; J. Robert Lane; György M. Keserű; Moran Shalev-Benami
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Quantification of drug rebinding at dopamine D2 receptor-expressing cell membranes with implications for extrapyramidal side effects在多巴胺D2受体表达细胞膜上对药物再结合进行定量，并探讨其对锥体外系副作用的影响
errCommunications Biology
IF5.1
err2026-08-19
err0
errOAAI
errHannah J. Lockington; Meritxell Canals; Jonathan A. Javitch; Stephen J. Briddon; J. Robert Lane
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err收藏
Dual-target mu opioid-dopamine D3 receptor (MOR-D3R) ligands based on etonitazene: New leads for transforming nitazenes into novel analgesics基于依诺硝唑的双靶点μ阿片-多巴胺D3受体(MOR-D3R)配体：将硝唑类化合物转化为新型镇痛药的新先导化合物
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-06-01
err0
PREAI
errJahan, Khorshada; Glatfelter, Grant; Sanchez, Julie; Maitland, Alexander D.; Bonifazi, Alessandro; Saab, Elizabeth; Keegan, Bradley M.; Rais, Rana; Bi, Guo-Hua; Gomez, Juan L.; Michaelides, Michael; Xi, Zheng-Xiong; Lane, J. Robert; Canals, Meritxell; Baumann, Michael H.; Newman, Amy Hauck
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Membrane Permeability Drives the Extreme Potency of Fentanyl膜通透性驱动芬太尼的极端效力
errJACS Au
IF8.7
err2026-02-18
err0
errOAAI
errJoseph Clayton; George J. Farmer; Jacqueline Glenn; Shailesh N. Mistry; J. Robert Lane; Lei Shi; Lidiya Stavitskaya; Meritxell Canals; Jana Shen
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Targeted inhibition of mu-opioid receptors in neuronal subpopulations by membrane-tethered Naloxo-DART antagonists通过膜锚定Naloxo-DART拮抗剂靶向抑制神经元亚群中的μ-阿片受体
errCell Chemical Biology
IF7.2
err2025-12-03
err0
errOAAI
errJ. Sanchez; A. Bonifazi; S. Groom; M.O. Sambrook; G.A. Camacho-Hernandez; E.J. Kuijer; S. Karimi; K.U. Therese; M. Hauge Pedersen; C. Rauffenbart; M. Canals; A.H. Newman; C.P. Bailey; J.A. Javitch; J.R. Lane
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Discovery; Characterization; and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D3 Dopamine Receptor发现、表征和优化一种新型的D3多巴胺受体阳性别构调节剂-拮抗剂
errJournal of Medicinal Chemistry
IF6.8
err2025-08-01
err0
PREAI
errAmy E. Moritz; Feijun Wang; Nora S. Madaras; Amber M. Kelley; Kirsten K. Snyder; Disha Gandhi; Laura R. Inbody; Emmanuel O. Akano; Lei Shi; J. Robert Lane; R. Benjamin Free; Kevin J. Frankowski; David R. Sibley
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Mu Opioid Receptor Activation is Required for NMDA Receptor Antagonist Effects on Stress-induced Maladaptive Behaviorμ阿片受体激活是NMDA受体拮抗剂对压力诱导的不良行为效应所必需的。
errBiological Psychiatry
IF9
err2025-07-07
err0
errOAAI
errCory B. Langreck; Briana Chen; Victor M. Luna; Mel Nelson; Gergely Turi; Rob Hill; Gilles Rubinstenn; Meritxell Canals; J. Robert Lane; Christine A. Denny; Jonathan A. Javitch
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Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor鉴定多巴胺D2受体正位别构调节剂的脂质暴露外旋结合位点
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2025-05-15
err0
PREAI
errLim, Herman D.; Bartuzi, Damian; Keen, Alastair C.; Rauffenbart, Caroline; Glenn, Jacqueline; Charlton, Steven J.; Lovera, Silvia; Sands, Zara A.; Ates, Ali; Wood, Martyn; Canals, Meritxell; Javitch, Jonathan A.; Carlsson, Jens; Lane, J. Robert
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Photo-BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-10-08
err0
errOAAI
errGerwe, Hubert; Schaller, Eva; Sortino, Rosalba; Opar, Ekin; Martinez-Tambella, Joaquin; Bermudez, Marcel; Lane, J. Robert; Gorostiza, Pau; Decker, Michael
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In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-02-12
err5
PREAI
errTsai, Meng-Hua M.; Chen, Li; Baumann, Michael H.; Canals, Meritxell; Javitch, Jonathan A.; Lane, J. Robert; Shi, Lei
err分享
err收藏
Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans
errCHEMICAL COMMUNICATIONS
IF4.2
err2024-01-01
err0
errOAAI
errMoore, Jonathan C.; Modell, Louis; Glenn, Jacqueline R.; Jones, Kieran D.; Argent, Stephen P.; Lane, J. Robert; Canals, Meritxell; Lam, Hon Wai
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Assessment of the potential of novel and classical opioids to induce respiratory depression in mice评估新型和经典阿片类药物诱导小鼠呼吸抑制的潜力
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2023-08-22
err6
errOAAI
errHill, Rob; Sanchez, Julie; Lemel, Laura; Antonijevic, Mirjana; Hosking, Yselkla; Mistry, Shailesh N.; Kruegel, Andrew C.; Javitch, Jonathan A.; Lane, J. Robert; Canals, Meritxell
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Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics双靶点多巴胺D3 (D3R) 和 μ-阿片 (MOR) 受体配体作为潜在更安全的镇痛药的药理和理化性质优化
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-07-19
err6
errOAAI
errBonifazi, Alessandro; Saab, Elizabeth; Sanchez, Julie; Nazarova, Antonina L.; Zaidi, Saheem A.; Jahan, Khorshada; Katritch, Vsevolod; Canals, Meritxell; Lane, J. Robert; Newman, Amy Hauck
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Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders基于Cariprazine的多巴胺D3/D2受体配体用于治疗可能被双重诊断为情感障碍的精神兴奋剂使用障碍
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-01-20
err3
errOAAI
errGogarnoiu, Emma S.; Vogt, Caleb D.; Sanchez, Julie; Bonifazi, Alessandro; Saab, Elizabeth; Shaik, Anver Basha; Soler-Cedeno, Omar; Bi, Guo-Hua; Klein, Benjamin; Xi, Zheng-Xiong; Lane, J. Robert; Newman, Amy Hauck
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The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2022-03-30
err14
errOAAI
errHill, Rob; Kruegel, Andrew C.; Javitch, Jonathan A.; Lane, J. Robert; Canals, Meritxell
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OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz
errCOMMUNICATIONS BIOLOGY
IF5.1
err2022-03-23
err9
errOAAI
errKeen, Alastair C.; Pedersen, Maria Hauge; Lemel, Laura; Scott, Daniel J.; Canals, Meritxell; Littler, Dene R.; Beddoe, Travis; Ono, Yuki; Shi, Lei; Inoue, Asuka; Javitch, Jonathan A.; Lane, J. Robert
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Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor
errMOLECULAR PHARMACOLOGY
IF3
err2021-10-01
err23
errOAAI
errFree, R. Benjamin; Cuoco, Caroline A.; Xie, Bing; Namkung, Yoon; Prabhu, Varun V.; Willette, Blair K. A.; Day, Marilyn M.; Sanchez-Soto, Marta; Lane, J. Robert; Laporte, Stephane A.; Shi, Lei; Allen, Joshua E.; Sibley, David R.
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Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor对映体富集的正变构调节剂在多巴胺D1受体上显示出独特的药理学
errMOLECULES
IF4.6
err2021-06-22
err1
errOAAI
errFyfe, Tim J.; Scammells, Peter J.; Lane, J. Robert; Capuano, Ben
err分享
err收藏
Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management新型双靶点 μ-阿片受体和多巴胺D3受体配体作为疼痛治疗的潜在非成瘾性药物治疗
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-05-20
err18
errOAAI
errBonifazi, Alessandro; Battiti, Francisco O.; Sanchez, Julie; Zaidi, Saheem A.; Bow, Eric; Makarova, Mariia; Cao, Jianjing; Shaik, Anver Basha; Sulima, Agnieszka; Rice, Kenner C.; Katritch, Vsevolod; Canals, Meritxell; Lane, J. Robert; Newman, Amy Hauck
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Optimization of ML321: a D2 dopamine receptor-selective antagonist for the treatment of neuropsychiatric disorders
errFASEB JOURNAL
IF4.2
err2021-05-14
err0
errOAAI
errRocereta, Julia; Free, R.; Garcia, Andres Dulcey; Southall, Noel; Shi, Lei; Lane, J.; Wetsel, William; Marugan, Juan; Sibley, David
err分享
err收藏

研究方向

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合作期刊
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M
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D
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