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J

Jonathan A. Javitch

Columbia University Vagelos College of Physicians and Surgeons

99H指数
430论文数
3.2W被引数
收录论文 212
发表时间
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Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning多巴胺D2受体绕过经典信号通路直接调节NMDA受体功能及厌恶学习
errScience Advances
IF12.5
err2026-07-23
err0
errOAAI
errSheng Gong; Joy Adler; Ying Zhu; Charlize Szeto; Lisa Lin; Caroline Rauffenbart; Arturo Torres-Herraez; Wesley B. Asher; Jonathan A. Javitch; Christopher P. Ford
err分享
err收藏
CD33 and clusterin interact biophysically and genetically to modulate Alzheimer riskCD33和clusterin通过生物物理和遗传途径相互作用以调节阿尔茨海默病风险
errNature Communications
IF15.7
err2026-07-17
err0
errOAAI
errRoger B. Dodd; Masahiro Enomoto; Ye Zhou; Kanayo Satoh; Yalun Zhang; Fusheng Chen; Beatrice Acheson; Deniz Ghaffari; Elizabeth Sayn-Wittgenstein; Jamie J. Manning; George V. Dukas; Ronak Patel; Alondra Schweizer Burguete; Mason J. Kralovec; Mamunur Rashid; Jennifer L. Hall; Kirstin A. Tamucci; Zena Chatila; Minghua Liu; Annie J. Lee; Badri N. Vardarajan; Mariko F. Taga; Sirkku Pollari; Alon Rabinovitch; Cory D. Rillahan; Andrey A. Bobkov; Eduard Sergienko; William Meadows; Seema Qamar; Suzanne J. Randle; Christopher M. Johnson; Jean Sevalle; Jennifer Griffin; Christopher Bohm; Mitsuhiko Ikura; Xunde Xian; Joachim Herz; Megan A. Kelly; Jennifer West; Sandeep Satapathy; Mark R. Wilson; Jonathan A. Javitch; Paul E. Fraser; David A. Bennett; Philip L. De Jager; Zvi Fishelson; Dan Frenkel; Wesley B. Asher; Elizabeth M. Bradshaw; Peter St George-Hyslop
err分享
err收藏
Molecular Pharmacology of mGlu7/8 Heterodimers Reveals Unique Properties of Orthosteric Agonists and Positive Allosteric ModulatorsmGlu7/8异源二聚体的分子药理学揭示了正构激动剂和正向别构调节剂的独特性质
errMolecular Pharmacology
IF3
err2026-06-06
err0
errOAAI
errAnthony S. Ferranti; Youhyun Noh; Xia Lei; Xin Lin; Joseph D. Bungard; Wesley B. Asher; Jonathan A. Javitch; Colleen M. Niswender
err分享
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Targeted inhibition of mu-opioid receptors in neuronal subpopulations by membrane-tethered Naloxo-DART antagonists通过膜锚定Naloxo-DART拮抗剂靶向抑制神经元亚群中的μ-阿片受体
errCell Chemical Biology
IF7.2
err2025-12-03
err0
errOAAI
errJ. Sanchez; A. Bonifazi; S. Groom; M.O. Sambrook; G.A. Camacho-Hernandez; E.J. Kuijer; S. Karimi; K.U. Therese; M. Hauge Pedersen; C. Rauffenbart; M. Canals; A.H. Newman; C.P. Bailey; J.A. Javitch; J.R. Lane
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Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale单分子尺度下对多样化生物系统的并行停流探测
errNature Methods
IF32.1
err2025-12-02
err0
errOAAI
errRoman Kiselev; Ryan A. Brady; Arnab Modak; F. Aaron Cruz-Navarrete; Jose L. Alejo; Daniel S. Terry; Roger B. Altman; Wesley B. Asher; Jonathan A. Javitch; Scott C. Blanchard
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Mu Opioid Receptor Activation is Required for NMDA Receptor Antagonist Effects on Stress-induced Maladaptive Behaviorμ阿片受体激活是NMDA受体拮抗剂对压力诱导的不良行为效应所必需的。
errBiological Psychiatry
IF9
err2025-07-07
err0
errOAAI
errCory B. Langreck; Briana Chen; Victor M. Luna; Mel Nelson; Gergely Turi; Rob Hill; Gilles Rubinstenn; Meritxell Canals; J. Robert Lane; Christine A. Denny; Jonathan A. Javitch
err分享
err收藏
Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor鉴定多巴胺D2受体正位别构调节剂的脂质暴露外旋结合位点
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2025-05-15
err0
PREAI
errLim, Herman D.; Bartuzi, Damian; Keen, Alastair C.; Rauffenbart, Caroline; Glenn, Jacqueline; Charlton, Steven J.; Lovera, Silvia; Sands, Zara A.; Ates, Ali; Wood, Martyn; Canals, Meritxell; Javitch, Jonathan A.; Carlsson, Jens; Lane, J. Robert
err分享
err收藏
Chronic administration of methocinnamox, a mu-opioid receptor antagonist, reduces hedonic response without impacting motivation in mice慢性给予美托西诺莫，一种μ-阿片受体拮抗剂，可降低小鼠的享乐反应，但不影响其动机。
errPSYCHOPHARMACOLOGY
IF3.3
err2025-05-10
err0
PREAI
errSheikh, Misbah; Cambre, Emily; Langreck, Cory; Javitch, Jonathan A.; Canetta, Sarah E.
err分享
err收藏
Complex G-protein signaling of the adhesion GPCR, ADGRA3黏附G蛋白偶联受体ADGRA3的复杂G蛋白信号传导
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-05-01
err0
errOAAI
errBagger, Sofie M.; Schihada, Hannes; Walser, Anna L. S.; Drzazga, Anna K.; Gratz, Lukas; Palmisano, Tiago; Kuhn, Christina K.; Mavri, Masa; Molleskov-Jensen, Ann-Sophie; Tall, Gregory G.; Schoeneberg, Torsten; Mathiasen, Signe J.; Javitch, Jonathan A.; Schulte, Gunnar; Spiess, Katja; Rosenkilde, Mette M.
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N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3N端片段脱落有助于全长粘附受体ADGRL3的信号传导
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-02-01
err0
PREAI
errPerry-Hauser, Nicole A.; Du Rand, Jonathan R.; Lee, Kuo Hao; Shi, Lei; Javitch, Jonathan A.
err分享
err收藏
Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer
errNATURE COMMUNICATIONS
IF15.7
err2024-10-03
err0
errOAAI
errLin, Xin; Provasi, Davide; Niswender, Colleen M.; Asher, Wesley B.; Javitch, Jonathan A.
err分享
err收藏
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
errNATURE COMMUNICATIONS
IF15.7
err2024-09-20
err0
errOAAI
errHavel, Vaclav; Kruegel, Andrew C.; Bechand, Benjamin; Mcintosh, Scot; Stallings, Leia; Hodges, Alana; Wulf, Madalee G.; Nelson, Mel; Hunkele, Amanda; Ansonoff, Michael; Pintar, John E.; Hwu, Christopher; Ople, Rohini S.; Abi-Gerges, Najah; Zaidi, Saheem A.; Katritch, Vsevolod; Yang, Mu; Javitch, Jonathan A.; Majumdar, Susruta; Hemby, Scott E.; Sames, Dalibor
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err收藏
Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-04-01
err1
PREAI
errLee, Wei-Li; Westergaard, Xavier; Hwu, Christopher; Hwu, Jennifer; Fiala, Tomas; Lacefield, Clay; Boltaev, Umed; Mendieta, Adriana M.; Lin, Lisa; Sonders, Mark S.; Brown, Keaon R.; He, Keer; Asher, Wesley B.; Javitch, Jonathan A.; Sulzer, David; Sames, Dalibor
err分享
err收藏
In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-02-12
err5
PREAI
errTsai, Meng-Hua M.; Chen, Li; Baumann, Michael H.; Canals, Meritxell; Javitch, Jonathan A.; Lane, J. Robert; Shi, Lei
err分享
err收藏
NEW POTENTIAL PHARMACOLOGICAL TARGETS FOR CHILDHOOD PSYCHIATRIC DISORDERS THROUGH DIFFERENTIAL MODULATION OF GLUTAMATE RECEPTORS
errJOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
IF9.5
err2023-10-01
err0
errOAAI
errSteinfeld, Justin B.; Lakhter, David; Javitch, Jonathan A.
err分享
err收藏
Assessment of the potential of novel and classical opioids to induce respiratory depression in mice评估新型和经典阿片类药物诱导小鼠呼吸抑制的潜力
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2023-08-22
err6
errOAAI
errHill, Rob; Sanchez, Julie; Lemel, Laura; Antonijevic, Mirjana; Hosking, Yselkla; Mistry, Shailesh N.; Kruegel, Andrew C.; Javitch, Jonathan A.; Lane, J. Robert; Canals, Meritxell
err分享
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Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling (vol 28, pg 1960, 2023)
errMOLECULAR PSYCHIATRY
IF10.1
err2023-08-07
err1
errOAAI
errJobin, Marie-Lise; De Smedt-Peyrusse, Veronique; Ducrocq, Fabien; Baccouch, Rim; Oummadi, Asma; Pedersen, Maria Hauge; Medel-Lacruz, Brian; Angelo, Maria-Florencia; Villette, Sandrine; Van Delft, Pierre; Fouillen, Laetitia; Mongrand, Sebastien; Selent, Jana; Tolentino-Cortez, Tarson; Barreda-Gomez, Gabriel; Gregoire, Stephane; Masson, Elodie; Durroux, Thierry; Javitch, Jonathan A.; Guixa-Gonzalez, Ramon; Alves, Isabel D.; Trifilieff, Pierre
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err收藏
A Novel Activation Switch Motif Common to All Aminergic Receptors
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-08-04
err4
errOAAI
errLee, Kuo Hao; Manning, Jamie J.; Javitch, Jonathan; Shi, Lei
err分享
err收藏
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2
errMOLECULAR METABOLISM
IF6.6
err2023-08-01
err6
errOAAI
errPetersen, Jacob Emil; Pedersen, Maria Hauge; Dmytriyeva, Oksana; Nellemose, Emilie; Arora, Tulika; Engelstoft, Maja Storm; Asher, Wesley B.; Javitch, Jonathan A.; Schwartz, Thue W.; Trauelsen, Mette
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Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain噻奈普汀在神经性疼痛的小鼠模型中促进持久的抗异常性疼痛作用
errNEUROPSYCHOPHARMACOLOGY
IF7.1
err2023-07-20
err4
PREAI
errSerafini, Randal. A. A.; Estill, Molly; Pekarskaya, Elizabeth. A. A.; Sakloth, Farhana; Shen, Li; Javitch, Jonathan. A. A.; Zachariou, Venetia
err分享
err收藏

研究方向

暂无研究方向
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