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蓝

蓝乐夫 (Lefu Lan)

Hangzhou Institute for Advanced Study

H指数:38

被引数:6,157

个人简介

任职于中国科学院上海药物研究所，现任研究员、研究组长。2006年于堪萨斯州立大学植物病理系从事博士后研究；2007年至2010年在芝加哥大学化学系从事博士后研究；2010年至今任现职。主要研究金黄色葡萄球菌、铜绿假单胞菌等病原菌的毒力因子表达调控及抗感染药物靶点。现任国际学术期刊Virulence杂志编委（2015-2017）、上海市微生物学会理事（2015.10-2019.9）。

教育背景

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工作经历

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荣誉奖项

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Lineage-specific type 1 fimbriae in hypervirulent ST23 Klebsiella pneumoniae target α3β1 integrin to promote intestinal epithelial invasion

ST23型高毒力肺炎克雷伯菌中特异性的Ⅰ型菌毛靶向α3β1整合素以促进肠道上皮侵袭

BMC Microbiology

IF4.2

2026-05-230

OAAI

Structure-Based Development of a Covalent Inhibitor Targeting Streptococcus Pyogenes over Staphylococcus Aureus Sortase A

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2025-03-010

PRE

Discovery of a novel polymyxin adjuvant against multidrug-resistant gram-negative bacteria through oxidative stress modulation

通过氧化应激调控发现一种新型多粘菌素佐剂，用于对抗多重耐药革兰氏阴性菌

ACTA PHARMACEUTICA SINICA B

IF14.6

2025-02-010

OAAI

C(sp3)-H Carbonylative Cyclization of Hydrazones with CO2: Synthesis of Pyrazolone Derivatives

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2024-12-100

PRE

Multisite modifications of arenes using ketones as removable handles enabled by Pd and norbornene cooperative catalysis

NATURE SYNTHESIS

IF20

2024-10-250

PRE

A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria (vol 67, pg 3778, 2024)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-04-020

OA

A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-03-055

PRE

Design, synthesis and biological evaluation of thiazolyl-halogenated pyrroles or pyrazoles as novel antibacterial and antibiofilm agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-03-013

PRE

A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-11-010

PRE

Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-03-223

PRE

Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

NATURE COMMUNICATIONS

IF15.7

2023-03-2211

OAAI

Single Modification at the N-Terminus of Norvancomycin to Combat Drug-Resistant Gram-Positive Bacteria

IF3.4

2023-03-147

PRE

Pd(II) Complexes of Chiral Proline-Derived Ligands: Application for Dynamic Thermodynamic Resolution of α-Amino Acids and Their Antibacterial Activities

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2023-03-037

PRE

The enzyme activity of sortase A is regulated by phosphorylation in Staphylococcus aureus

IF5.4

2023-02-105

OAAI

The opportunistic pathogen Pseudomonas aeruginosa exploits bacterial biotin synthesis pathway to benefit its infectivity

机会性病原体铜绿假单胞菌利用细菌生物素合成途径来提高其感染性

IF4.9

2023-01-2314

OAAI

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

NATURE COMMUNICATIONS

IF15.7

2022-11-1417

OAAI

Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected ?-Amino Acids and Their Antibacterial Activity

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2022-09-265

PRE

Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge Rhabdastrella globostellata

JOURNAL OF NATURAL PRODUCTS

IF3.6

2022-06-2912

PRE

Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

铜绿假单胞菌: 发病机制，毒力因子，抗生素耐药性，与宿主的相互作用，技术进步和新兴疗法

Signal Transduction and Targeted Therapy

IF52.7

2022-06-251.3K

OA

Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2

新型氯硝柳胺衍生的佐剂可提高多粘菌素b对MDR铜绿假单胞菌DK2的疗效

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-06-016

PRE