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S

Sérgio Valente

Sapienza University of Rome
H指数:51
被引数:8,341

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Mutant Huntingtin disrupts neurogenic and astroglial programs via the EZH2–Let-7g–LIN28 axis with rescue by epigenetic modulators

突变亨廷蛋白通过EZH2–Let-7g–LIN28轴破坏神经发生和星形胶质细胞程序，并由表观遗传调节剂进行挽救

Cell Death and Differentiation
IF15.4
2026-07-160
OAAI
JD Rosati; A. Casamassa; G. Ruotolo; AMG Giovenale; D. D’Andrea; G. Rotundo; A. D’Anzi; EM Turco; G. Bergonzoni; A. Visioli; I. Lombardi; RM Carletti; U. Cappucci; AM Casale; A. Migazzi; M. Ciavarella; A. Rinaldi; C. Bertollini; V. Giambra; A. De Luca; D. Rotili; S. Valente; E. Binda; O. Palumbo; M. Gelati; F. Squitieri; L. Piacentini; D. Ferrari; S. Di Angelantonio; M. Catalano; A. Mai; M. Biagioli; M. Basso; M. Pennuto; B. Reynolds; AL Vescovi
A synergistic interaction between PRMT5 and LSD1 inhibitors in AML

PRMT5与LSD1抑制剂的协同作用在AML中

Science Advances
IF12.5
2026-03-270
OA
Nesteene Joy Param; Elisa Arceci; Francesco Fiorentino; Luca Pignata; Denis Torre; Nayeli Gutiérrez-Trejo; Jia Yi Fong; Pierre-Alexis Goy; Brenda Y. Han; Chiara Lambona; Elisabetta Di Bello; Carola Castiello; Marco Barone; Megan Schwarz; Cheryl Arrowsmith; Koichi Ito; Peggy Scherle; Dave Keng Boon Wee; Steven Ndoye; Tommaso Tabaglio; Anand D. Jeyasekharan; Manikandan Lakshmanan; Roberto Cirilli; Hansjörg Habisch; Tobias Madl; Andrea Mattevi; Sergio Valente; Antonello Mai; Ernesto Guccione
Dynamic epigenetic regulation of BCLAF1 splicing in acute myeloid leukemia

急性髓系白血病中BCLAF1剪接的动态表观遗传调控

Cell Death & Disease
IF9.6
2026-03-240
OAAI
Giulia Sgueglia; Crescenzo Massaro; Annamaria Muro; Ida Lettiero; Erika D’Agostino; Gregorio Favale; Nicla Simonelli; Nunzio Del Gaudio; Vincenzo Carafa; Tommaso De Marchi; Dante Rotili; Sergio Valente; Antonello Mai; Gianluca Sbardella; Mariacarla De Simone; Lucia Altucci; Carmela Dell’Aversana
Simplification and Derivatization of Quinoline-Containing M41 Lead to the Discovery of NADPH Oxidase Isoform-Selective Inhibitors Effective in Cancer Cells

喹啉基M41的简化与衍生化导致NADPH氧化酶同工酶选择性抑制剂在癌细胞中的发现

Journal of Medicinal Chemistry
IF6.8
2026-01-010
OA
Chiara Lambona; Sara Marchese; Beatrice Noce; Marta Massari; Davide Ciampoli; Francesco Fiorentino; Clemens Zwergel; Emanuele Fabbrizi; Andrea Mancini; Francesco Quilli; Federico Pandolfi; Alessia Raucci; Rossella Fioravanti; Davide Corinti; Matteo Ré; Alessandro Mormino; Stefano Garofalo; Cristina Limatola; Donato Mele; Lucia Capasso; Rosaria Casalino; Angela Nebbioso; Lucia Altucci; Domenico Raimondo; Andrea Mattevi; Antonello Mai; Sérgio Valente
Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties

喹啉类DNA甲基转移酶抑制剂：含碱性侧链的设计、合成及对生化与抗癌细胞特性的见解

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-11-010
PRE
Zwergel, Clemens; Lambona, Chiara; Fioravanti, Rossella; Raucci, Alessia; Fiorentino, Francesco; Nchugoua Tchieh, Guilaine; Jallet, Corinne; Lacroix, Laurent; Pierrettori, Michela; Pellegrini, Francesca Romana; Xiong, Yan; Jin, Jian; Arimondo, Paola; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio
TP53-Agnostic Lethality through Combined Pan-HDAC and CDK Inhibition in Acute Myeloid Leukemia

TP53非依赖性细胞死亡通过联合泛组蛋白去乙酰化酶和CDK抑制剂在急性髓系白血病中的作用

Cancer Letters
IF10.1
2025-09-010
PREAI
Aurélien Pottier; Sujung Park; Yejin Lee; Francesca Liccardo; Haeun Yang; Jeonghye Park; Anne Lorant; Michael Schnekenburger; Davide Brusa; Vladimir Li; Sergio Valente; Antonello Mai; Sarah J. Skuli; Martin Carroll; Steffen Boettcher; Jean-Emmanuel Sarry; Claudia Cerella; Franck Morceau; Marc Diederich
Long noncoding RNA H19 promotes the acquisition of a mesenchymal-like invasive phenotype in mesothelial primary cells through an HDAC1-mediated WT1/Sp1 switch

长链非编码RNA H19通过HDAC1介导的WT1/Sp1转换促进间皮源性细胞获得类间充质样侵袭表型。

Cell Death & Disease
IF9.6
2025-08-310
OAAI
Giulio Bontempi; Federica Michetti; Michela Terri; Cecilia Battistelli; Alice Conigliaro; Sabrina Garbo; Claudia Montaldo; Sergio Valente; Clemens Zwergel; Antonello Mai; Azadeh Nahavandi Araghi; Alessandro Domenici; Paolo Menè; Marco Tripodi; Raffaele Strippoli
Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

基于Tranylcypromine的LSD1抑制剂作为降低Schistosoma mansoni存活率的潜在有效药物

ACS Infectious Diseases
IF3.8
2025-07-020
OA
Emanuele Fabbrizi; Gebremedhin Solomon Hailu; A. Ganesan; Rossella Fioravanti; Clemens Zwergel; Chiara Lambona; Sergio Valente; Giulia Fianco; Angela Iuzzolino; Daniela Trisciuoglio; Jonatan Caroli; Andrea Mattevi; Cécile Häberli; Jennifer Keiser; Dante Rotili; Antonello Mai
HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks
CELL DEATH DISCOVERY
IF7
2024-08-062
OAAI
Cassandri, Matteo; Porrazzo, Antonella; Pomella, Silvia; Noce, Beatrice; Zwergel, Clemens; Aiello, Francesca Antonella; Vulcano, Francesca; Milazzo, Luisa; Camero, Simona; Pajalunga, Deborah; Spada, Massimo; Manzi, Valeria; Gravina, Giovanni Luca; Codenotti, Silvia; Piccione, Michela; Tomaciello, Miriam; Signore, Michele; Barillari, Giovanni; Marchese, Cinzia; Fanzani, Alessandro; De Angelis, Biagio; Quintarelli, Concetta; Vakoc, Christopher R.; Chen, Eleanor Y.; Megiorni, Francesca; Locatelli, Franco; Valente, Sergio; Mai, Antonello; Rota, Rossella; Marampon, Francesco
HDAC3 sustains resistance to hypofractionated radiotherapy in fusion positve rhabdomyosarcoma cells
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Cassandri, Matteo; Porrazzo, Antonella; Pomella, Silvia; Camero, Simona; Aiello, Francesca A.; D'Archivio, Lucrezia; Zwergel, Clemens; Noce, Beatrice; Tomaciello, Miriam; Vulcano, Francesca; Milazzo, Luisa; Pedini, Francesca; Signore, Michele; Fanzani, Alessandro; Marchese, Cinzia; Minniti, Giuseppe; Valente, Sergio; Mai, Antonello; Megiorni, Francesca; Rota, Rossella; Marampon, Francesco
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
2024-01-232
OAAI
Terri, Michela; Sandoval, Pilar; Bontempi, Giulio; Montaldo, Claudia; Tomero-Sanz, Henar; de Turris, Valeria; Trionfetti, Flavia; Pascual-Anton, Lucia; Clares-Pedrero, Irene; Battistelli, Cecilia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Rosano, Laura; del Pozo, Miguel angel; Sanchez-Alvarez, Miguel; Cabanas, Carlos; Tripodi, Marco; Lopez-Cabrera, Manuel; Strippoli, Raffaele

研究方向

暂未获取到该数据
A
Antonello Mai
H 指数:75论文数:622被引数:2.0万
C
Clemens Zwergel
H 指数:32论文数:122被引数:3,084
D
Dante Rotili
H 指数:52论文数:277被引数:8,838
L
Lucia Altucci
H 指数:75论文数:594被引数:2.9万
R
Rossella Fioravanti
H 指数:30论文数:105被引数:2,952
A
Angela Nebbioso
H 指数:50论文数:185被引数:8,309
G
Giulia Stazi
H 指数:18论文数:43被引数:900
R
Rino Ragno
H 指数:46论文数:218被引数:6,509
E
Elisabetta Di Bello
H 指数:12论文数:18被引数:533
D
Daniela Trisciuoglio
H 指数:42论文数:162被引数:1.2万