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Sanfetrinem, an oral (3-lactam antibiotic repurposed for the treatment of tuberculosis Sanfetrinem，一种用于治疗结核病的口服β-内酰胺类抗生素。 Ramon-Garcia, Santiago; del Rio, Ruben Gonzalez; Arenaz-Callao, Maria Pilar; Boshoff, Helena I.; Rullas, Joaquin; Anca, Sara; Izquierdo, Monica Cacho; de Francisco, Esther Porras; Herran, Esther Perez; Santos-Villarejo, Angel; Mendoza-Losana, Alfonso; Ferrer-Bazaga, Santiago; Thompson, Charles J.; Aguirre, David Barros; Bates, Robert H. 分享 收藏
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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs Green, Simon R.; Davis, Susan H.; Damerow, Sebastian; Engelhart, Curtis A.; Mathieson, Michael; Baragana, Beatriz; Robinson, David A.; Tamjar, Jevgenia; Dawson, Alice; Tamaki, Fabio K.; Buchanan, Kirsteen, I; Post, John; Dowers, Karen; Shepherd, Sharon M.; Jansen, Chimed; Zuccotto, Fabio; Gilbert, Ian H.; Epemolu, Ola; Riley, Jennifer; Stojanovski, Laste; Osuna-Cabello, Maria; Perez-Herran, Esther; Rebollo, Maria Jose; Lopez, Laura Guijarro; Castro, Patricia Casado; Camino, Isabel; Kim, Heather C.; Bean, James M.; Nahiyaan, Navid; Rhee, Kyu Y.; Wang, Qinglan; Tan, Vee Y.; Boshoff, Helena I. M.; Converse, Paul J.; Li, Si-Yang; Chang, Yong S.; Fotouhi, Nader; Upton, Anna M.; Nuermberger, Eric L.; Schnappinger, Dirk; Read, Kevin D.; Encinas, Lourdes; Bates, Robert H.; Wyatt, Paul G.; Cleghorn, Laura A. T. 分享 收藏
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment Nuermberger, Eric L.; Martinez-Martinez, Maria Santos; Sanz, Olalla; Urones, Beatriz; Esquivias, Jorge; Soni, Heena; Tasneen, Rokeya; Tyagi, Sandeep; Li, Si-Yang; Converse, Paul J.; Boshoff, Helena I.; Robertson, Gregory T.; Besra, Gurdyal S.; Abrahams, Katherine A.; Upton, Anna M.; Mdluli, Khisimuzi; Boyle, Gary W.; Turner, Sam; Fotouhi, Nader; Cammack, Nicholas C.; Siles, Juan Miguel; Alonso, Marta; Escribano, Jaime; Lelievre, Joel; Rullas-Trincado, Joaquin; Perez-Herran, Esther; Bates, Robert H.; Maher-Edwards, Gareth; Barros, David; Ballell, Lluis; Jimenez, Elena 分享 收藏
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions 由制药公司和学术机构组成的财团鉴定对结核分枝杆菌具有活性的 β-内酰胺 Gold, Ben; Zhang, Jun; Quezada, Landys Lopez; Roberts, Julia; Ling, Yan; Wood, Madeleine; Shinwari, Wasima; Goullieux, Laurent; Roubert, Christine; Fraisse, Laurent; Bacque, Eric; Lagrange, Sophie; Filoche-Romme, Bruno; Vieth, Michal; Hipskind, Philip A.; Jungheim, Louis N.; Aube, Jeffrey; Scarry, Sarah M.; McDonald, Stacey L.; Li, Kelin; Perkowski, Andrew; Nguyen, Quyen; Dartois, Veronique; Zimmerman, Matthew; Olsen, David B.; Young, Katherine; Bonnett, Shilah; Joerss, Douglas; Parish, Tanya; Boshoff, Helena, I; Arora, Kriti; Barry, Clifton E., III; Guijarro, Laura; Anca, Sara; Rullas, Joaquin; Rodriguez-Salguero, Beatriz; Martinez-Martinez, Maria S.; Porras-De Francisco, Esther; Cacho, Monica; Barros-Aguirre, David; Smith, Paul; Berthel, Steven J.; Nathan, Carl; Bates, Robert H. 分享 收藏
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target Wilson, Caroline; Ray, Peter; Zuccotto, Fabio; Hernandez, Jorge; Aggarwal, Anup; Mackenzie, Claire; Caldwell, Nicola; Taylor, Malcolm; Huggett, Margaret; Mathieson, Michael; Murugesan, Dinakaran; Smith, Alasdair; Davis, Susan; Cocco, Mattia; Parai, Maloy K.; Acharya, Arjun; Tamaki, Fabio; Scullion, Paul; Epemolu, Ola; Riley, Jennifer; Stojanovski, Laste; Lopez-Roman, Eva Maria; Torres-Gomez, Pedro Alfonso; Toledo, Ana Maria; Guijarro-Lopez, Laura; Camino, Isabel; Engelhart, Curtis A.; Schnappinger, Dirk; Massoudi, Lisa M.; Lenaerts, Anne; Robertson, Gregory T.; Walpole, Chris; Matthews, David; Floyd, David; Sacchettini, James C.; Read, Kevin D.; Encinas, Lourdes; Bates, Robert H.; Green, Simon R.; Wyatt, Paul G. 分享 收藏
The Tuberculosis Drug Accelerator at year 10: what have we learned? Aldridge, Bree B.; Barros-Aguirre, David; Barry, Clifton E., III; Bates, Robert H.; Berthel, Steven J.; Boshoff, Helena I.; Chibale, Kelly; Chu, Xin-Jie; Cooper, Christopher B.; Dartois, Veronique; Duncan, Ken; Fotouhi, Nader; Gusovsky, Fabian; Hipskind, Philip A.; Kempf, Dale J.; Lelievre, Joel; Lenaerts, Anne J.; McNamara, Case W.; Mizrahi, Valerie; Nathan, Carl; Olsen, David B.; Parish, Tanya; Petrassi, H. Michael; Pym, Alexander; Rhee, Kyu Y.; Robertson, Gregory T.; Rock, Jeremy Michael; Rubin, Eric J.; Russell, Betsy; Russell, David G.; Sacchettini, James C.; Schnappinger, Dirk; Schrimpf, Michael; Upton, Anna M.; Warner, Peter; Wyatt, Paul Graham; Yuan, Ying 分享 收藏
Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity Botros, Liza; Pronk, Manon C. A.; Juschten, Jenny; Liddle, John; Morsing, Sofia K. S. H.; van Buul, Jaap D.; Bates, Robert H.; Tuinman, Pieter R.; van Bezu, Jan S. M.; Huveneers, Stephan; Bogaard, Harm Jan; van Hinsbergh, Victor W. M.; Hordijk, Peter L.; Aman, Jurjan 分享 收藏
Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-D-Ribose Oxidase (DprE1) Inhibitors Balabon, Olga; Pitta, Eleni; Rogacki, Maciej K.; Meiler, Eugenia; Casanueva, Ruth; Guijarro, Laura; Huss, Sophie; Maria Lopez-Roman, Eva; Santos-Villarejo, Angel; Augustyns, Koen; Ballell, Lluis; Barros Aguirre, David; Bates, Robert H.; Cunningham, Fraser; Cacho, Monica; Van der Veken, Pieter 分享 收藏
Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite Cunningham, Fraser; Esquivias, Jorge; Fernandez-Menendez, Raquel; Perez, Arancha; Guardia, Ana; Escribano, Jaime; Rivero, Cristina; Vimal, Mythily; Cacho, Monica; De Dios-Anton, Paco; Martinez-Martinez, Maria Santos; Jimenez, Elena; Valentin, Leticia Huertas; Rebollo-Lopez, Maria Jose; Lopez-Roman, Eva Maria; Sousa-Morcuende, Veronica; Rullas, Joaquin; Neu, Margaret; Chung, Chun-wa; Bates, Robert H. 分享 收藏
Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis Poce, Giovanna; Consalvi, Sara; Venditti, Giulia; Alfonso, Salvatore; Desideri, Nicoletta; Fernandez-Menendez, Raquel; Bates, Robert H.; Ballell, Lluis; Aguirre, David Barros; Rullas, Joaquin; De Logo, Alessandro; Gardner, Michelle; Ioerger, Thomas R.; Rubin, Eric J.; Biava, Mariangela 分享 收藏
Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors Rogacki, Maciej K.; Pitta, Eleni; Balabon, Olga; Huss, Sophie; Lopez-Roman, Eva Maria; Argyrou, Argyrides; Blanco-Ruano, Delia; Cacho, Monica; Vande Velde, Christophe M. L.; Augustyns, Koen; Ballell, Lluis; Barros, David; Bates, Robert H.; Cunningham, Fraser; Van der Veken, Pieter 分享 收藏
Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1 Richter, Adrian; Rudolph, Ines; Moellmann, Ute; Voigt, Kerstin; Chung, Chun-wa; Singh, Onkar M. P.; Rees, Michael; Mendoza-Losana, Alfonso; Bates, Robert; Ballell, Lluis; Batt, Sarah; Veerapen, Natacha; Futterer, Klaus; Besra, Gurdyal; Imming, Peter; Argyrou, Argyrides 分享 收藏
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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening (vol 8, pg 16081, 2017) Machutta, Carl A.; Kollmann, Christopher S.; Lind, Kenneth E.; Bai, Xiaopeng; Chan, Pan F.; Huang, Jianzhong; Ballell, Lluis; Belyanskaya, Svetlana; Besra, Gurdyal S.; Barros-Aguirre, David; Bates, Robert H.; Centrella, Paolo A.; Chang, Sandy S.; Chai, Jing; Choudhry, Anthony E.; Coffin, Aaron; Davie, Christopher P.; Deng, Hongfeng; Deng, Jianghe; Ding, Yun; Dodson, Jason W.; Fosbenner, David T.; Gao, Enoch N.; Graham, Taylor L.; Graybill, Todd L.; Ingraham, Karen; Johnson, Walter P.; King, Bryan W.; Kwiatkowski, Christopher R.; Lelievre, Joel; Li, Yue; Liu, Xiaorong; Lu, Quinn; Lehr, Ruth; Mendoza-Losana, Alfonso; Martin, John; McCloskey, Lynn; McCormick, Patti; O'Keefe, Heather P.; O'Keeffe, Thomas; Pao, Christina; Phelps, Christopher B.; Qi, Hongwei; Rafferty, Keith; Scavello, Genaro S.; Steiginga, Matt S.; Sundersingh, Flora S.; Sweitzer, Sharon M.; Szewczuk, Lawrence M.; Taylor, Amy; Toh, May Fern; Wang, Juan; Wang, Minghui; Wilkins, Devan J.; Xia, Bing; Yao, Gang; Zhang, Jean; Zhou, Jingye; Donahue, Christine P.; Messer, Jeffrey A.; Holmes, David; Arico-Muendel, Christopher C.; Pope, Andrew J.; Gross, Jeffrey W.; Evindar, Ghotas 分享 收藏
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA Prati, Federica; Zuccotto, Fabio; Fletcher, Daniel; Convery, Maire A.; Fernandez-Menendez, Raquel; Bates, Robert; Encinas, Lourdes; Zeng, Jingkun; Chung, Chun-wa; De Dios Anton, Paco; Mendoza-Losana, Alfonso; Mackenzie, Claire; Green, Simon R.; Huggett, Margaret; Barros, David; Wyatt, Paul G.; Ray, Peter C. 分享 收藏
In vivo potent BM635 analogue with improved drug-like properties Poce, Giovanna; Cocozza, Martina; Alfonso, Salvatore; Consalvi, Sara; Venditti, Giulia; Fernandez-Menendez, Raquel; Bates, Robert H.; Barros Aguirre, David; Ballell, Lluis; De Logu, Alessandro; Vistoli, Giulio; Biava, Mariangela 分享 收藏
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