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M

Matthias R. Bauer

novartis

23H指数
63论文数
2.2K被引数
收录论文 28
发表时间
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A 24-Day MicroCycle Journey to Interleukin-17 Inhibitors: From Library Design to Central Core Prioritization and Capping Group Identification24天微循环探索白细胞介素-17抑制剂：从文库设计到核心中心优先排序和封端基团识别
errChemMedChem
IF3.4
err2026-05-20
err0
PREAI
errSophie Racine; Odile Decoret; Marco Palmieri; Matthias R. Bauer; Juraj Velcicky; Sylvie Teixeira-Fouchard; Sina Schmid; Roland Steiner; Estelle Ngo; Carol Ginsburg-Moraff; William Ulmer; Kate Alexandra Wieser; Driss Ouzineb; Simone Riek; Patrick Schmutz; Thomas Knoepfel; Nina Gommermann; Cara E. Brocklehurst
err分享
err收藏
Harnessing Glutamine-117 Plasticity toward Structure-Based Identification of Triazole IL-17 Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err0
PREAI
errBauer, Matthias R.; Velcicky, Juraj; Goetz, Alban; Furet, Pascal; Nimsgern, Pierre; Tichkule, Ritesh; Schlapbach, Achim; Meyer, Arndt; Vogtle, Markus; Rolando, Catherine; Lehmann, Hansjoerg; Berst, Frederic; Riek, Simone; Schmutz, Patrick; Lehmann, Sylvie; Scheufler, Clemens; Rondeau, Jean-Michel; Burkhart, Christoph; Gommermann, Nina; Knoepfel, Thomas
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Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen从DNA编码库筛选中发现STUB1/CHIP E3连接酶的小分子配体
errACS Medicinal Chemistry Letters
IF4
err2025-08-05
err0
PREAI
errSimon C. C. Lucas; Alexander G. Milbradt; Jason Breed; Erwin De Genst; Anne Jackson; Alisa Solovyeva; Bryony Ackroyd; Matthias R. Bauer; Juntai Liu; David Longmire; Dušan Petrović; Emma L. Rivers; Christopher Stubbs; Poppy Winlow; Sana Bazzaz; Paige Dickson; Diana Gikunju; Marie-Aude Guié; John P. Guilinger; Christopher D. Hupp; Rachael Jetson; Anthony D. Keefe; Katherine Nugai; John T. S. Yeoman; Ying Zhang; Xian Feng; Dequan Yu; Christopher Phillips
err分享
err收藏
Thiazole-Based IL-17 Inhibitors Discovered by Scaffold Morphing
errCHEMMEDCHEM
IF3.4
err2025-01-12
err0
PREAI
errVelcicky, Juraj; Ngo, Estelle; Bauer, Matthias R.; Meyer, Arndt; Schlapbach, Achim; Racine, Sophie; Orain, David; Pflieger, Daniel; Teixeira-Fouchard, Sylvie; Dubois, Celine; Goetz, Alban; Steiner, Roland; Palmieri, Marco; Bussenault, Alex; Stringer, Rowan; Larger, Patrice; Riek, Simone; Schmutz, Patrick; Lehmann, Sylvie; Scheufler, Clemens; Rondeau, Jean-Michel; Burkhart, Christoph; Knoepfel, Thomas; Gommermann, Nina
err分享
err收藏
Discovery and In Vivo Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-14
err0
PREAI
errVelcicky, Juraj; Bauer, Matthias R.; Schlapbach, Achim; Lapointe, Guillaume; Meyer, Arndt; Vogtle, Markus; Blum, Ernst; Ngo, Estelle; Rolando, Catherine; Nimsgern, Pierre; Teixeira-Fouchard, Sylvie; Lehmann, Hansjoerg; Furet, Pascal; Berst, Frederic; Schumann, Jens; Stringer, Rowan; Larger, Patrice; Schmid, Cindy; Prendergast, Catriona T.; Riek, Simone; Schmutz, Patrick; Lehmann, Sylvie; Berghausen, Jorg; Scheufler, Clemens; Rondeau, Jean-Michel; Burkhart, Christoph; Knoepfel, Thomas; Gommermann, Nina
err分享
err收藏
mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B
errACS CHEMICAL BIOLOGY
IF3.8
err2024-04-24
err2
errOAAI
errCremosnik, Gregor S.; Mesrouze, Yannick; Zueger, Patrik; Furkert, David; Grandjean, Frederic; Argoti, Dayana; Mermet-Meillon, Fanny; Bauer, Matthias R.; Brittain, Scott; Rogemoser, Phuong; Yang, Winnie; Giovannoni, Jerome; Mcgregor, Lynn; Tang, Jenny; Knapp, Mark; Holzinger, Sandra; Buhr, Sylvia; Muller, Lionel; Leder, Lukas; Xie, Lili; Fernandez, Cesar; Nieto-Oberhuber, Cristina; Chene, Patrick; Galli, Giorgio G.; Sesterhenn, Fabian
err分享
err收藏
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-03-21
err2
PREAI
errLucas, Simon C. C.; Ahmed, Afshan; Ashraf, S. Neha; Argyrou, Argyrides; Bauer, Matthias R.; De Donatis, Gian Marco; Demanze, Sylvain; Eisele, Frederik; Fusani, Lucia; Hock, Andreas; Kadamur, Ganesh; Li, Shuyou; Macmillan-Jones, Abigail; Michaelides, Iacovos N.; Phillips, Christopher; Rehnstrom, Marie; Richter, Magdalena; Rodrigo-Brenni, Monica C.; Shilliday, Fiona; Wang, Peng; Storer, R. Ian
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Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-05-24
err7
PREAI
errWhitehurst, Benjamin C.; Bauer, Matthias R.; Edfeldt, Fredrik; Gunnarsson, Anders; Margreitter, Christian; Rawlins, Philip B.; Storer, R. Ian
err分享
err收藏
DockStream: a docking wrapper to enhance de novo molecular designDockStream: 一种用于增强从头分子设计的对接包装器
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2021-11-17
err35
errOAAI
errGuo, Jeff; Janet, Jon Paul; Bauer, Matthias R.; Nittinger, Eva; Giblin, Kathryn A.; Papadopoulos, Kostas; Voronov, Alexey; Patronov, Atanas; Engkvist, Ola; Margreitter, Christian
err分享
err收藏
Put a ring on it: application of small aliphatic rings in medicinal chemistry
errRSC Medicinal Chemistry
IF3.6
err2021-01-01
err255
errOAAI
errBauer, Matthias R.; Di Fruscia, Paolo; Lucas, Simon C. C.; Michaelides, Iacovos N.; Nelson, Jennifer E.; Storer, R. Ian; Whitehurst, Benjamin C.
err分享
err收藏
Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking
errFRONTIERS IN CHEMISTRY
IF4.2
err2020-11-05
err32
errOAAI
errIbrahim, Tamer M.; Ismail, Muhammad I.; Bauer, Matthias R.; Bekhit, Adnan A.; Boeckler, Frank M.
err分享
err收藏
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm
errACS CHEMICAL BIOLOGY
IF3.8
err2020-01-28
err55
errOAAI
errBauer, Matthias R.; Kraemer, Andreas; Settanni, Giovanni; Jones, Rhiannon N.; Ni, Xiaomin; Tareque, Raysa Khan; Fersht, Alan R.; Spencer, John; Joerger, Andreas C.
err分享
err收藏
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C
errFUTURE MEDICINAL CHEMISTRY
IF3.4
err2019-10-21
err70
errOAAI
errBauer, Matthias R.; Jones, Rhiannon N.; Tareque, Raysa K.; Springett, Bradley; Dingler, Felix A.; Verduci, Lorena; Patel, Ketan J.; Fersht, Alan R.; Joerger, Andreas C.; Spencer, John
err分享
err收藏
Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein-Ligand Complexes
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-02-26
err98
PREAI
errBauer, Matthias R.; Mackey, Mark D.
err分享
err收藏
A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathwayIII型补体因子D缺乏症: 抑制替代途径的结构见解
errJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
IF11.2
err2018-07-01
err11
errOAAI
errSng, Christopher C. T.; O'Byrne, Sorcha; Prigozhin, Daniil M.; Bauer, Matthias R.; Harvey, Jennifer C.; Ruhle, Michelle; Challis, Ben G.; Lear, Sara; Roberts, Lee D.; Workman, Sarita; Janowitz, Tobias; Magiera, Lukasz; Doffinger, Rainer; Buckland, Matthew S.; Jodrell, Duncan J.; Semple, Robert K.; Wilson, Timothy J.; Modis, Yorgo; Thaventhiran, James E. D.
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err收藏
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2018-05-01
err73
errOAAI
errBaud, Matthias G. J.; Bauer, Matthias R.; Verduci, Lorena; Dingier, Felix A.; Patel, Ketan J.; Roy, Deeptee Horil; Joerger, Andreas C.; Fersht, Alan R.
err分享
err收藏
The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2018-03-01
err43
errOAAI
errMadan, Esha; Parker, Taylor M.; Bauer, Matthias R.; Dhiman, Alisha; Pelham, Christopher J.; Nagane, Masaki; Kuppusamy, M. Lakshmi; Holmes, Matti; Holmes, Thomas R.; Shaik, Kranti; Shee, Kevin; Kiparoidze, Salome; Smith, Sean D.; Park, Yu-Soon A.; Gomm, Jennifer J.; Jones, Louise J.; Tomas, Ana R.; Cunha, Ana C.; Selvendiran, Karuppaiyah; Hansen, Laura A.; Fersht, Alan R.; Hideg, Kalman; Gogna, Rajan; Kuppusamy, Periannan
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err收藏
Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007
errCANCER LETTERS
IF10.1
err2018-02-01
err53
PREAI
errSynnott, Naoise C.; Bauer, Matthias R.; Madden, Stephen; Murray, Alyson; Klinger, Rut; O'Donovan, Norma; O'Connor, Darran; Gallagher, William M.; Crown, John; Fersht, Alan R.; Duffy, Michael J.
err分享
err收藏
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2016-08-22
err102
errOAAI
errBauer, Matthias R.; Joerger, Andreas C.; Fersht, Alan R.
err分享
err收藏
Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs
errACS CHEMICAL BIOLOGY
IF3.8
err2016-06-21
err63
errOAAI
errBauer, Matthias R.; Jones, Rhiannon N.; Baud, Matthias G. J.; Wilcken, Rainer; Boeckler, Frank M.; Fersht, Alan R.; Joerger, Andreas C.; Spencer, John
err分享
err收藏

研究方向

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合作学者
合作期刊
A
Anne Jackson
H 指数: 95 · 论文数: 1.2K
A
Alan R. Fersht
H 指数: 94 · 论文数: 345
C
C. W. Stubbs
H 指数: 91 · 论文数: 752
J
John Crown
H 指数: 88 · 论文数: 865
M
Michael J. Duffy
H 指数: 85 · 论文数: 352
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