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Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy 人类brachyury DNA识别的结构洞察与癌症治疗进展性结合物的发现 Newman, Joseph A.; Gavard, Angeline E.; Imprachim, Nergis; Aitkenhead, Hazel; Sheppard, Hadley E.; te Poele, Robert; Clarke, Paul A.; Oh, Hans J.; Wells, Carrow I.; Davis-Gilbert, Zachary W.; Gileadi, Opher; Drewry, David H. 分享 收藏
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Discovery of ARID1A loss as a patient biomarker for NXP800-A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer te Poele, Robert H.; Powers, Marissa; Sharp, Swee; de Billy, Emmanuel; Taskinen, Maria; Pellegrino, Loredana; Gowan, Sharon; Miah, Asadh; Hayes, Angela; Cheeseman, Matthew; Jones, Keith; Eccles, Suzanne; Raynaud, Florence; Clarke, Paul; Workman, Paul 分享 收藏
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Using acquired resistance to explore the mechanism of action of the integrated stress response/GCN2 activator NXP800-A new developmental agent for platinum-resistant ARID1A mutant ovarian cancer Powers, Marissa V.; Hodgson, Rachel; Sharp, Swee Y.; Roe, Toby; Allen, K. Elizabeth; Campbell, Susan; te Poele, Robert; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul 分享 收藏
Integrating fragment-based crystallographic screening with dTAG-PROTAC degradation and genetic rescue to explore the function of eIF4EIntegrating fragment-based crystallographic screening with dTAG-PROTAC degradation and genetic rescue to explore the function of eIF4E Clarke, Paul A.; Sharp, Swee Y.; Martella, Marianna; Milton, Christopher I.; East, Charlotte; Vinkovic, Mladen; Wallis, Nicola; Ward, George; Richardson, Caroline; Woodhead, Andrew 分享 收藏
Activation of the integrated stress response by NXP800, an orally available, clinical-stage, investigational agent in ARID1A-mutated, platinum resistant ovarian cancer Powers, Marissa V.; Swap, Swee Y.; te Poele, Robert; Lampraki, Eirini-Maria; Roe, Toby; Pellegrino, Loredana; Taskinen, Maria; Eccles, Suzenne; Raynaud, Florence; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul 分享 收藏
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Activation of the integrated stress response by the developmental HSF1 pathway inhibitor NXP800 Powers, Marissa V.; Sharp, Swee Y.; Lampraki, Eirini-Maria; Roe, Toby; Pellegrino, Loredana; Taskinen, Maria; Poele, Robert Te; Raynaud, Florence; Eccles, Suzanne; Cheeseman, Matthew; Jones, Keith; Clarke, Paul A.; Workman, Paul 分享 收藏
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies Pasqua, A. Elisa; Sharp, Swee Y.; Chessum, Nicola E. A.; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J.; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E.; Rye, Carl S.; Mok, N. Yi; Liu, Manjuan; Henley, Alan T.; Gowan, Sharon; De Billy, Emmanuel; te Poele, Robert; Powers, Marissa; Eccles, Suzanne A.; Clarke, Paul A.; Raynaud, Florence I.; Workman, Paul; Jones, Keith; Cheeseman, Matthew D. 分享 收藏
SETD2 is a novel and druggable dependency in IMiD/CELMoD resistant multiple myeloma models Bird, Sarah Anne; Licciardello, Marco; Chrisochoidou, Yakinthi; Smith, James; Barber, Amy; Cheung, Jack; Grabovska, Yura; Martin, Shannon; Sialana, Fernando; Che, Harvey; Bouguenina, Habib; Bellenie, Benjamin; Walker, Brian; Clarke, Paul; Pawlyn, Charlotte 分享 收藏
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Native Size-Exclusion Chromatography-Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes Samant, Rahul S.; Batista, Silvia; Larance, Mark; Ozer, Bugra; Milton, Christopher I.; Bludau, Isabell; Wu, Estelle; Biggins, Laura; Andrews, Simon; Hervieu, Alexia; Johnston, Harvey E.; Al-Lazikhani, Bissan; Lamond, Angus I.; Clarke, Paul A.; Workman, Paul 分享 收藏
A comparative analysis of extracellular vesicles (EVs) from human and feline plasma Howard, Jane; Wynne, Kieran; Moldenhauer, Evelin; Clarke, Paul; Maguire, Ciaran; Bollard, Stephanie; Yin, Xiaofei; Brennan, Lorraine; Mooney, Louise; Fitzsimons, Stephen; Halasz, Melinda; Aluri, Ester Rani; Brougham, Dermot F.; Kolch, Walter; Dwyer, Roisin M.; Potter, Shirley; Kelly, Pamela; McCann, Amanda 分享 收藏
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Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma Poon, Evon; Liang, Tong; Jamin, Yann; Walz, Susanne; Kwok, Colin; Hakkert, Anne; Barker, Karen; Urban, Zuzanna; Thway, Khin; Zeid, Rhamy; Hallsworth, Albert; Box, Gary; Ebus, Marli E.; Licciardello, Marco P.; Sbirkov, Yordan; Lazaro, Glori; Calton, Elizabeth; Costa, Barbara M.; Valenti, Melanie; Brandon, Alexis De Haven; Webber, Hannah; Tardif, Nicolas; Almeida, Gilberto S.; Christova, Rossitza; Boysen, Gunther; Richards, Mark W.; Barone, Giuseppe; Ford, Anthony; Bayliss, Richard; Clarke, Paul A.; De Bono, Johann; Gray, Nathanael S.; Blagg, Julian; Robinson, Simon P.; Eccles, Suzanne A.; Zheleva, Daniella; Bradner, James E.; Molenaar, Jan; Vivanco, Igor; Eilers, Martin; Workman, Paul; Lin, Charles Y.; Chesler, Louis 分享 收藏
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