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H

Hiroshi Yamazaki

showa pharmaceutical university

74H指数
1.1K论文数
2.7W被引数
收录论文 193
发表时间
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Tyrosine kinase inhibitors suppress cytochrome P450 2C8 and 2J2 functions and their expression in renal cell carcinoma酪氨酸激酶抑制剂抑制肾细胞癌中细胞色素P450 2C8和2J2的功能及其表达
errDrug Metabolism and Pharmacokinetics
IF2.2
err2026-05-29
err0
PREAI
errAyaka Kojima; Masayuki Nadai; Hiroshi Yamazaki; Miki Katoh
err分享
err收藏
Biphasic dextromethorphan O-demethylation in tree shrews mediated by liver microsomal cytochromes P450 with high and low affinities树鼩肝微粒体细胞色素P450介导的双相右美沙芬O-脱甲基化（高亲和力与低亲和力）
errDrug Metabolism and Disposition
IF4
err2026-05-12
err0
PREAI
errGenki Ushirozako; Atsushi Asano; Konosuke Otomaru; Kyoko Tsukiyama-Kohara; Hiroshi Yamazaki; Yasuhiro Uno
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err收藏
Baseline variations in in vivo cytochrome P450 3A-dependent phenotypes evaluated using concentrations of endogenous or deuterium-labeled cortisol and their 6β-hydroxylated metabolites in 103 cynomolgus monkeys and 20 humanized-liver mice transplanted with hepatocytes基线条件下，通过内源性或氘标记的皮质醇及其6β-羟基化代谢物的浓度，评估了103只食蟹猴和20只移植了肝细胞的人源化肝脏小鼠中，活体内细胞色素P450 3A依赖性表型的变化。
errDrug Metabolism and Disposition
IF4
err2026-03-28
err0
PREAI
errShotaro Uehara; Yuichiro Higuchi; Suguru Fukuda; Makiko Shimizu; Akihito Shimoi; Hiroshi Suemizu; Hiroshi Yamazaki
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Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide5887只狗中，黄素单加氧酶（FMO）1和FMO3的遗传变异影响了探针底物苯茚胺、三甲胺和对甲苯硫醚的氧化反应。
errBiochemical Pharmacology
IF5.6
err2026-02-10
err0
PREAI
errYasuhiro Uno; Koya Fukunaga; Makiko Shimizu; Genki Ushirozako; Keijiro Mizukami; Tomomi Aoi; Hirotaka Tomiyasu; Muneki Honnami; Hajime Tsujimoto; Masahiro Sakaguchi; Masaharu Hisasue; Taisei Mushiroda; Yukihide Momozawa; Hiroshi Yamazaki
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Prediction of Human Hepatic Clearance with HepaSH Monolayers for Low-Turnover Compounds使用HepaSH单层细胞预测低周转化合物的肝清除率
errDrug Metabolism and Disposition
IF4
err2025-11-11
err0
errOAAI
errShotaro Uehara; Yuichiro Higuchi; Nao Yoneda; Hiroshi Yamazaki; Hiroshi Suemizu
err分享
err收藏
Human Plasma and Urine Concentrations of Triethylamine and Its N-Oxide after Oral Administration Extrapolated Using Pharmacokinetic Modeling: Comparison with Trimethylamine and Its N-Oxide
errBIOLOGICAL & PHARMACEUTICAL BULLETIN
IF1.7
err2025-11-01
err0
PREAI
errShimizu, Makiko; Shimura, Yukia; Yamazaki, Hiroshi
err分享
err收藏
Genetic variants in dog cytochrome P450 2B6 and their relevance to inter-individual variability of oxidations of probe drug propofol犬细胞色素P450 2B6的遗传变异及其与探针药物丙泊酚氧化反应个体间变异的相关性
errDrug Metabolism and Disposition
IF4
err2025-10-30
err0
PREAI
errYasuhiro Uno; Koya Fukunaga; Genki Ushirozako; Norie Murayama; Keijiro Mizukami; Tomomi Aoi; Hirotaka Tomiyasu; Muneki Honnami; Hajime Tsujimoto; Masahiro Sakaguchi; Masaharu Hisasue; Taisei Mushiroda; Yukihide Momozawa; Hiroshi Yamazaki
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err收藏
Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole通过筛查6344只狗，鉴定出的细胞色素P450 2C21基因变异体影响了探针药物奥美拉唑的氧化作用。
errBiochemical Pharmacology
IF5.6
err2025-10-03
err0
PREAI
errYasuhiro Uno; Koya Fukunaga; Genki Ushirozako; Norie Murayama; Keijiro Mizukami; Tomomi Aoi; Hirotaka Tomiyasu; Muneki Honnami; Hajime Tsujimoto; Masahiro Sakaguchi; Masaharu Hisasue; Taisei Mushiroda; Yukihide Momozawa; Hiroshi Yamazaki
err分享
err收藏
Tyrosine kinase inhibitors, nilotinib and radotinib, suppress both catalytic function and mRNA expression of human cytochrome P450 2J2 and 2C8酪氨酸激酶抑制剂 nilotinib 和 radotinib 抑制人细胞色素 P450 2J2 和 2C8 的催化功能及 mRNA 表达。
errDrug Metabolism and Pharmacokinetics
IF2.2
err2025-08-29
err0
PREAI
errAyaka Kojima; Masayuki Nadai; Hiroshi Yamazaki; Miki Katoh
err分享
err收藏
Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs三乙胺N-氧化反应由肝脏和肾脏微粒体以及来自人类、猴子、猪和狗的重组黄素单加氧酶3（FMO3）和FMO1蛋白介导。
errDrug Metabolism and Disposition
IF4
err2025-08-05
err0
PREAI
errMakiko Shimizu; Anna Nii; Yasuhiro Uno; Hiroshi Yamazaki
err分享
err收藏
Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations研究猪细胞色素P450 1A2、2A19、2C33、2D25和3A22的基因多态性，以阐明肝脏药物氧化的个体间变异。
errBiochemical Pharmacology
IF5.6
err2025-08-05
err0
PREAI
errYasuhiro Uno; Genki Ushirozako; Norie Murayama; Hiroshi Yamazaki
err分享
err收藏
Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with In Silico-Generated Input Parameters使用简化的生理基础药代动力学模型，结合计算机模拟生成的输入参数，预测大鼠和人体在虚拟口服不同化学物质后的内部暴露情况。
errChemical Research in Toxicology
IF3.8
err2025-07-08
err0
PREAI
errHiroshi Yamazaki; Makiko Shimizu
err分享
err收藏
Staging classification of atypical ulnar fractures不典型尺骨骨折的分期分类
errArchives of Osteoporosis
IF2.8
err2025-06-19
err0
errOAAI
errTetsushi Kinoshita; Fumihiro Isobe; Hiroshi Yamazaki; Koichi Nakamura; Shun Hashimoto; Teruki Shirayama; Hiroko Iwakawa; Masanori Hayashi; Jun Takahashi
err分享
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Exploration of functional cytochrome P450 4F enzymes in liver, intestine, and kidney from dogs, cats, pigs, and tree shrews and comparison of their metabolic capacities with human P450 4F2 and 4F12对来自犬、猫、猪和树鼩肝脏、肠道和肾脏的功能性细胞色素P450 4F酶的探索，以及将其代谢能力与人类P450 4F2和4F12的比较
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2025-06-01
err0
PREAI
errUno, Yasuhiro; Kawabata, Izumi; Ushirozako, Genki; Tsukiyama-Kohara, Kyoko; Ishizuka, Mayumi; Mizukawa, Hazuki; Murayama, Norie; Yamazaki, Hiroshi
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Current status of Imaging Mass Spectrometry in drug discovery and development: A survey highlighting technical challenges and future directions成像质谱在药物发现与发展中的现状：一项强调技术挑战和未来方向的综述
errDRUG METABOLISM AND PHARMACOKINETICS
IF2.2
err2025-06-01
err0
PREAI
errTanaka, Yukari; Yokoi, Hiroyuki; Kaji, Hidefumi; Urasaki, Yoko; Nishidate, Masanobu; Nitta, Shin-ichiro; Watanabe, Kenichi; Ishida, Tomomi; Tanaka, Kouji; Komatsu, Rika; Yoshida, Kenji; Saito, Kosuke; Saito, Yoshiro; Yamazaki, Hiroshi
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Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies基于来自计算机模拟研究的细胞色素P450酶的药物基因组学数据，用于临床环境中使用的日本药物标签
errDrug Metabolism and Pharmacokinetics
IF2.2
err2025-05-29
err0
PREAI
errYoichi Tanaka; Makiko Shimizu; Yoshiro Saito; Hiroshi Yamazaki
err分享
err收藏
Contribution of Japanese scientists to drug metabolism and disposition日本科学家对药物代谢和分布的贡献
errDRUG METABOLISM AND DISPOSITION
IF4
err2025-05-01
err0
PREAI
errNakajima, Miki; Yamazaki, Hiroshi; Yoshinari, Kouichi; Kobayashi, Kaoru; Ishii, Yuji; Nakai, Daisuke; Kamimura, Hidetaka; Kume, Toshiyuki; Saito, Yoshiro; Maeda, Kazuya; Kusuhara, Hiroyuki; Tamai, Ikumi
err分享
err收藏
Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2025-05-01
err0
PREAI
errUno, Yasuhiro; Ushirozako, Genki; Murayama, Norie; Yamazaki, Hiroshi
err分享
err收藏
Investigation of pilocarpine oxidative and hydrolytic metabolism in chimeric mice with humanized liver人源化肝脏嵌合小鼠中毛果芸香碱氧化和水解代谢的研究
errDrug Metabolism and Pharmacokinetics
IF2.2
err2025-04-14
err0
PREAI
errShotaro Uehara; Yuichiro Higuchi; Nao Yoneda; Hiroshi Yamazaki; Hiroshi Suemizu
err分享
err收藏
Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2025-02-01
err1
PREAI
errKoinuma, Kana; Noto, Kenji; Morita, Tokio; Uekusa, Yoshinori; Kikuchi, Haruhisa; Shimoji, Miyuki; Seki, Hiroyuki; Yamazaki, Hiroshi; Guengerich, F. Peter; Nakamura, Katsunori; Yamamoto, Koujirou; Imaoka, Ayuko; Akiyoshi, Takeshi; Ohtani, Hisakazu
err分享
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