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M

Makiko Shimizu

Showa Pharmaceutical University

42H指数
358论文数
6.9K被引数
收录论文 93
发表时间
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Baseline variations in in vivo cytochrome P450 3A-dependent phenotypes evaluated using concentrations of endogenous or deuterium-labeled cortisol and their 6β-hydroxylated metabolites in 103 cynomolgus monkeys and 20 humanized-liver mice transplanted with hepatocytes基线条件下，通过内源性或氘标记的皮质醇及其6β-羟基化代谢物的浓度，评估了103只食蟹猴和20只移植了肝细胞的人源化肝脏小鼠中，活体内细胞色素P450 3A依赖性表型的变化。
errDrug Metabolism and Disposition
IF4
err2026-03-28
err0
PREAI
errShotaro Uehara; Yuichiro Higuchi; Suguru Fukuda; Makiko Shimizu; Akihito Shimoi; Hiroshi Suemizu; Hiroshi Yamazaki
err分享
err收藏
Human Plasma and Urine Concentrations of Triethylamine and Its N-Oxide after Oral Administration Extrapolated Using Pharmacokinetic Modeling: Comparison with Trimethylamine and Its N-Oxide
errBIOLOGICAL & PHARMACEUTICAL BULLETIN
IF1.7
err2025-11-01
err0
PREAI
errShimizu, Makiko; Shimura, Yukia; Yamazaki, Hiroshi
err分享
err收藏
Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs三乙胺N-氧化反应由肝脏和肾脏微粒体以及来自人类、猴子、猪和狗的重组黄素单加氧酶3（FMO3）和FMO1蛋白介导。
errDrug Metabolism and Disposition
IF4
err2025-08-05
err0
PREAI
errMakiko Shimizu; Anna Nii; Yasuhiro Uno; Hiroshi Yamazaki
err分享
err收藏
Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with In Silico-Generated Input Parameters使用简化的生理基础药代动力学模型，结合计算机模拟生成的输入参数，预测大鼠和人体在虚拟口服不同化学物质后的内部暴露情况。
errChemical Research in Toxicology
IF3.8
err2025-07-08
err0
PREAI
errHiroshi Yamazaki; Makiko Shimizu
err分享
err收藏
Effects of peritoneal dialysis fluids on arginine vasopressin dynamics in humans and transgenic rats腹膜透析液对人类和转基因大鼠精氨酸加压素动力学的影响
errPeritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
IF0
err2025-06-23
err0
PREAI
errHiromichi Ueno; Yoichi Ueta; Yuki Nonaka; Tomohito Shirouzu; Naofumi Ikeda; Ikutaro Furuno; Kazutoshi Nakazono; Emi Hasegawa; Makiko Shimizu; Junichiro Koga; Takashi Maruyama; Tetsu Miyamoto; Masaharu Kataoka
err分享
err收藏
Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies基于来自计算机模拟研究的细胞色素P450酶的药物基因组学数据，用于临床环境中使用的日本药物标签
errDrug Metabolism and Pharmacokinetics
IF2.2
err2025-05-29
err0
PREAI
errYoichi Tanaka; Makiko Shimizu; Yoshiro Saito; Hiroshi Yamazaki
err分享
err收藏
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-10-01
err3
PREAI
errUno, Yasuhiro; Shimizu, Makiko; Yamazaki, Hiroshi
err分享
err收藏
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2024-04-16
err1
PREAI
errUehara, Shotaro; Murayama, Norie; Higuchi, Yuichiro; Shimizu, Makiko; Suemizu, Hiroshi; Guengerich, F. Peter; Yamazaki, Hiroshi
err分享
err收藏
Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews
errCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
IF4.3
err2024-03-01
err2
PREAI
errUno, Yasuhiro; Makiguchi, Miaki; Ushirozako, Genki; Tsukiyama-Kohara, Kyoko; Shimizu, Makiko; Yamazaki, Hiroshi
err分享
err收藏
Deschloroclozapine exhibits an exquisite agonistic effect at lower concentration compared to clozapine-N-oxide in hM3Dq expressing chemogenetically modified rats
errFRONTIERS IN NEUROSCIENCE
IF3.2
err2023-11-30
err4
errOAAI
errShimizu, Makiko; Yoshimura, Mitsuhiro; Baba, Kazuhiko; Ikeda, Naofumi; Nonaka, Yuki; Maruyama, Takashi; Onaka, Tatsushi; Ueta, Yoichi
err分享
err收藏
Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers
errepidemiology
IF3
err2023-06-05
err3
errOAAI
errHoang, Dong V.; Akter, Shamima; Inoue, Yosuke; Kuwahara, Keisuke; Fukunaga, Ami; Islam, Zobida; Nakagawa, Tohru; Honda, Toru; Yamamoto, Shuichiro; Okazaki, Hiroko; Miyamoto, Toshiaki; Ogasawara, Takayuki; Sasaki, Naoko; Uehara, Akihiko; Yamamoto, Makoto; Kochi, Takeshi; Eguchi, Masafumi; Shirasaka, Taiki; Shimizu, Makiko; Nagahama, Satsue; Hori, Ai; Imai, Teppei; Nishihara, Akiko; Tomita, Kentaro; Nishiura, Chihiro; Konishi, Maki; Kabe, Isamu; Yamamoto, Kenya; Mizoue, Tetsuya; Dohi, Seitaro
err分享
err收藏
Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats
errCOMMUNICATIONS BIOLOGY
IF5.1
err2022-09-05
err19
errOAAI
errNishimura, Haruki; Yoshimura, Mitsuhiro; Shimizu, Makiko; Sanada, Kenya; Sonoda, Satomi; Nishimura, Kazuaki; Baba, Kazuhiko; Ikeda, Naofumi; Motojima, Yasuhito; Maruyama, Takashi; Nonaka, Yuki; Baba, Ryoko; Onaka, Tatsushi; Horishita, Takafumi; Morimoto, Hiroyuki; Yoshida, Yasuhiro; Kawasaki, Makoto; Sakai, Akinori; Muratani, Masafumi; Conway-Campbell, Becky; Lightman, Stafford; Ueta, Yoichi
err分享
err收藏
Diagnosis-specific Cumulative Incidence of Return-to-work, Resignation, and Death Among Long-term Sick-listed Employees: Findings From the Japan Epidemiology Collaboration on Occupational Health Study长期患病的员工重返工作，辞职和死亡的诊断特异性累积发生率: 日本流行病学职业健康合作研究的发现
errepidemiology
IF3
err2022-09-05
err2
errOAAI
errNishiura, Chihiro; Inoue, Yosuke; Kashino, Ikuko; Nanri, Akiko; Endo, Motoki; Eguchi, Masafumi; Kochi, Takeshi; Kato, Noritada; Shimizu, Makiko; Imai, Teppei; Nishihara, Akiko; Yamamoto, Makoto; Okazaki, Hiroko; Tomita, Kentaro; Miyamoto, Toshiaki; Yamamoto, Shuichiro; Nakagawa, Tohru; Honda, Toru; Ogasawara, Takayuki; Sasaki, Naoko; Hori, Ai; Kabe, Isamu; Mizoue, Tetsuya; Dohi, Seitaro
err分享
err收藏
Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats猪，狗和猫中黄素单加氧酶的分子和功能表征
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2022-08-01
err18
errOAAI
errUno, Yasuhiro; Shimizu, Makiko; Ogawa, Yurie; Makiguchi, Miaki; Kawaguchi, Hiroaki; Yamato, Osamu; Ishizuka, Mayumi; Yamazaki, Hiroshi
err分享
err收藏
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats (vol 34, pg 2180, 2021)
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2022-07-29
err2
PREAI
errKamiya, Yusuke; Handa, Kentaro; Miura, Tomonori; Ohori, Junya; Shimizu, Makiko; Kitajima, Masato; Shono, Fumiaki; Funatsu, Kimito; Yamazaki, Hiroshi
err分享
err收藏
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2021-09-29
err8
PREAI
errKamiya, Yusuke; Handa, Kentaro; Miura, Tomonori; Ohori, Junya; Shimizu, Makiko; Kitajima, Masato; Shono, Fumiaki; Funatsu, Kimito; Yamazaki, Hiroshi
err分享
err收藏
Loss of Working Life Years Due to Mortality, Sickness Absence, or Ill-health Retirement: A Comprehensive Approach to Estimating Disease Burden in the Workplace由于死亡，疾病缺席或健康状况不佳的退休而导致的工作寿命损失: 估算工作场所疾病负担的综合方法
errepidemiology
IF3
err2021-07-05
err7
errOAAI
errInoue, Yosuke; Nomura, Shuhei; Nishiura, Chihiro; Hori, Ai; Yamamoto, Kenya; Nakagawa, Tohru; Honda, Toru; Yamamoto, Shuichiro; Eguchi, Masafumi; Kochi, Takeshi; Miyamoto, Toshiaki; Okazaki, Hiroko; Imai, Teppei; Nishihara, Akiko; Ogasawara, Takayuki; Sasaki, Naoko; Uehara, Akihiko; Yamamoto, Makoto; Shimizu, Makiko; Konishi, Maki; Kabe, Isamu; Mizoue, Tetsuya; Dohi, Seitaro
err分享
err收藏
Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality in a Japanese Working Population: Japan Epidemiology Collaboration on Occupational Health Study
errDIABETES CARE
IF16.6
err2021-01-13
err32
errOAAI
errIslam, Zobida; Akter, Shamima; Inoue, Yosuke; Hu, Huan; Kuwahara, Keisuke; Nakagawa, Tohru; Honda, Toru; Yamamoto, Shuichiro; Okazaki, Hiroko; Miyamoto, Toshiaki; Ogasawara, Takayuki; Sasaki, Naoko; Uehara, Akihiko; Yamamoto, Makoto; Kochi, Takeshi; Eguchi, Masafumi; Shirasaka, Taiki; Shimizu, Makiko; Nagahama, Satsue; Hori, Ai; Imai, Teppei; Nishihara, Akiko; Tomita, Kentaro; Sone, Tomofumi; Konishi, Maki; Kabe, Isamu; Mizoue, Tetsuya; Dohi, Seitaro
err分享
err收藏
In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2021-01-12
err29
PREAI
errKamiya, Yusuke; Handa, Kentaro; Miura, Tomonori; Yanagi, Mayu; Shigeta, Kazuki; Hina, Shiori; Shimizu, Makiko; Kitajima, Masato; Shono, Fumiaki; Funatsu, Kimito; Yamazaki, Hiroshi
err分享
err收藏
Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2020-12-06
err7
PREAI
errMiura, Tomonori; Shimizu, Makiko; Uehara, Shotaro; Yoshizawa, Manae; Nakano, Ayane; Yanagi, Mayu; Kamiya, Yusuke; Murayama, Norie; Suemizu, Hiroshi; Yamazaki, Hiroshi
err分享
err收藏

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