Scott Houliston

University of Toronto

H指数:18

被引数:1,856

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Dual-site phosphorylation of SLX4 stabilizes the SLX4-MUS81 interface to promote mitotic SMX assembly and genome protection

SLX4的双位点磷酸化稳定SLX4-MUS81界面以促进有丝分裂SMX组装和基因组保护

Nucleic Acids Research

IF13.1

2026-05-220

PRE

Large-scale discovery, analysis and design of protein energy landscapes

大规模蛋白质能量景观的发现、分析与设计

Nature

IF48.5

2026-05-130

OAAI

Enantioselective protein affinity selection mass spectrometry (E-ASMS)

手性蛋白质亲和选择质谱法 (E-ASMS)

Nature Communications

IF15.7

2025-12-170

OAAI

Xiaoyun Wang; Jianxian Sun; Shabbir Ahmad; Diwen Yang; Fengling Li; U. Hang Chan; Hong Zeng; Conrad V. Simoben; Stuart R. Green; Madhushika Silva; Scott Houliston; Aiping Dong; Albina Bolotokova; Elisa Gibson; Maria Kutera; Pegah Ghiabi; Ivan Kondratov; Tetiana Matviyuk; Alexander Chuprina; Danai Mavridi; Christopher Lenz; Andreas C. Joerger; Benjamin D. Brown; Richard B. Heath; Wyatt W. Yue; Lucy K. Robbie; Tyler S. Beyett; Susanne Müller; Stefan Knapp; Dafydd R. Owen; Rachel Harding; Matthieu Schapira; Peter J. Brown; Vijayaratnam Santhakumar; Suzanne Ackloo; Cheryl H. Arrowsmith; Aled M. Edwards; Hui Peng; Levon Halabelian

Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

手性选择性化学探针用于查加斯病毒nsP2解旋酶，并具有抗阿尔法病毒活性

ACS Infectious Diseases

IF3.8

2025-07-180

Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity

直接作用型nsP2解旋酶抑制剂的抗甲病毒活性鉴定

Journal of Medicinal Chemistry

IF6.8

2025-07-090

Bose Muthu Ramalingam; John D. Sears; Kacey M. Talbot; Yuan-Wei Norman Su; Scott Houliston; Mohammed Anwar Hossain; Zachary W. Davis-Gilbert; Chunqing Zhao; Hans J. Oh; Peter J. Brown; Marcia K. Sanders; Stella R. Moorman; Durbadal Ojha; Jane E. Burdick; Isabella Law; Noah L. Morales; Sabian A. Martinez; Peter Loppnau; Julia Garcia Perez; Adam M. Drobish; Thomas E. Morrison; Zachary J. Streblow; Daniel N. Streblow; Cheryl H. Arrowsmith; Ava Vargason; Rafael M. Couñago; Levon Halabelian; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

CACHE挑战赛#2：靶向SARS-CoV-2解旋酶Nsp13的RNA位点

Journal of Chemical Information and Modeling

IF5.3

2025-06-200

PRE

Oleksandra Herasymenko; Madhushika Silva; Abd Al-Aziz A. Abu-Saleh; Ayaz Ahmad; Jesus Alvarado-Huayhuaz; Oscar E. A. Arce; Roly J. Armstrong; Cheryl Arrowsmith; Kelly E. Bachta; Hartmut Beck; Denes Berta; Mateusz K. Bieniek; Vincent Blay; Albina Bolotokova; Philip E. Bourne; Marko Breznik; Peter J. Brown; Aaron D. G. Campbell; Emanuele Carosati; Irene Chau; Daniel J. Cole; Ben Cree; Wim Dehaen; Katrin Denzinger; Karina dos Santos Machado; Ian Dunn; Prasannavenkatesh Durai; Kristina Edfeldt; Aled Edwards; Darren Fayne; Daniel Felfoldi; Kallie Friston; Pegah Ghiabi; Elisa Gibson; Judith Günther; Anders Gunnarsson; Alexander Hillisch; Douglas R. Houston; Jan Halborg Jensen; Rachel J. Harding; Kate S. Harris; Laurent Hoffer; Anders Hogner; Joshua T. Horton; Scott Houliston; Judd F. Hultquist; Ashley Hutchinson; John J. Irwin; Marko Jukič; Shubhangi Kandwal; Andrea Karlova; Vittorio L. Katis; Ryan P. Kich; Dmitri Kireev; David Koes; Nicole L. Inniss; Uta Lessel; Sijie Liu; Peter Loppnau; Wei Lu; Sam Martino; Miles McGibbon; Jens Meiler; Akhila Mettu; Sam Money-Kyrle; Rocco Moretti; Yurii S. Moroz; Charuvaka Muvva; Joseph A. Newman; Leon Obendorf; Brooks Paige; Amit Pandit; Keunwan Park; Sumera Perveen; Rachael Pirie; Gennady Poda; Mykola Protopopov; Vera Pütter; Federico Ricci; Natalie J. Roper; Edina Rosta; Margarita Rzhetskaya; Yogesh Sabnis; Karla J. F. Satchell; Frederico Schmitt Kremer; Thomas Scott; Almagul Seitova; Casper Steinmann; Valerij Talagayev; Olga O. Tarkhanova; Natalie J. Tatum; Dakota Treleaven; Adriano Velasque Werhli; W. Patrick Walters; Xiaowen Wang; Jude Wells; Geoffrey Wells; Yvonne Westermaier; Gerhard Wolber; Lars Wortmann; Jixian Zhang; Zheng Zhao; Shuangjia Zheng; Matthieu Schapira

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities

基于模拟配体结合亲和力的主动学习引导的富含亮氨酸重复激酶2 WDR结构域命中优化

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2025-05-260

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1

由FRASE-bot在CACHE Challenge #1中鉴定的靶向LRRK2 WD40重复结构域的功能性活性调节剂

CHEMICAL SCIENCE

IF7.4

2025-01-010

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2024-11-054

Li, Fengling; Ackloo, Suzanne; Arrowsmith, Cheryl H.; Ban, Fuqiang; Barden, Christopher J.; Beck, Hartmut; Beranek, Jan; Berenger, Francois; Bolotokova, Albina; Bret, Guillaume; Breznik, Marko; Carosati, Emanuele; Chau, Irene; Chen, Yu; Cherkasov, Artem; Della Corte, Dennis; Denzinger, Katrin; Dong, Aiping; Draga, Sorin; Dunn, Ian; Edfeldt, Kristina; Edwards, Aled; Eguida, Merveille; Eisenhuth, Paul; Friedrich, Lukas; Fuerll, Alexander; Gardiner, Spencer S.; Gentile, Francesco; Ghiabi, Pegah; Gibson, Elisa; Glavatskikh, Marta; Gorgulla, Christoph; Guenther, Judith; Gunnarsson, Anders; Gusev, Filipp; Gutkin, Evgeny; Halabelian, Levon; Harding, Rachel J.; Hillisch, Alexander; Hoffer, Laurent; Hogner, Anders; Houliston, Scott; Irwin, John J.; Isayev, Olexandr; Ivanova, Aleksandra; Jacquemard, Celien; Jarrett, Austin J.; Jensen, Jan H.; Kireev, Dmitri; Kleber, Julian; Koby, S. Benjamin; Koes, David; Kumar, Ashutosh; Kurnikova, Maria G.; Kutlushina, Alina; Lessel, Uta; Liessmann, Fabian; Liu, Sijie; Lu, Wei; Meiler, Jens; Mettu, Akhila; Minibaeva, Guzel; Moretti, Rocco; Morris, Connor J.; Narangoda, Chamali; Noonan, Theresa; Obendorf, Leon; Pach, Szymon; Pandit, Amit; Perveen, Sumera; Poda, Gennady; Polishchuk, Pavel; Puls, Kristina; Puetter, Vera; Rognan, Didier; Roskams-Edris, Dylan; Schindler, Christina; Sindt, Francois; Spiwok, Vojtech; Steinmann, Casper; Stevens, Rick L.; Talagayev, Valerij; Tingey, Damon; Vu, Oanh; Walters, W. Patrick; Wang, Xiaowen; Wang, Zhenyu; Wolber, Gerhard; Wolf, Clemens Alexander; Wortmann, Lars; Zeng, Hong; Zepeda, Carlos A.; Zhang, Kam Y. J.; Zhang, Jixian; Zheng, Shuangjia; Schapira, Matthieu

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-11-040

OAAI

Ackloo, Suzanne; Li, Fengling; Szewczyk, Magda; Seitova, Almagul; Loppnau, Peter; Zeng, Hong; Xu, Jin; Ahmad, Shabbir; Arnautova, Yelena A.; Baghaie, A. J.; Beldar, Serap; Bolotokova, Albina; Centrella, Paolo A.; Chau, Irene; Clark, Matthew A.; Cuozzo, John W.; Dehghani-Tafti, Saba; Disch, Jeremy S.; Dong, Aiping; Dumas, Antoine; Feng, Jianwen A.; Ghiabi, Pegah; Gibson, Elisa; Gilmer, Justin; Goldman, Brian; Green, Stuart R.; Guie, Marie-Aude; Guilinger, John P.; Harms, Nathan; Herasymenko, Oleksandra; Houliston, Scott; Hutchinson, Ashley; Kearnes, Steven; Keefe, Anthony D.; Kimani, Serah W.; Kramer, Trevor; Kutera, Maria; Kwak, Haejin A.; Lento, Cristina; Li, Yanjun; Liu, Jenny; Loup, Joachim; Machado, Raquel A. C.; Mulhern, Christopher J.; Perveen, Sumera; Righetto, Germanna L.; Riley, Patrick; Shrestha, Suman; Sigel, Eric A.; Silva, Madhushika; Sintchak, Michael D.; Slakman, Belinda L.; Taylor, Rhys D.; Thompson, James; Torng, Wen; Underkoffler, Carl; von Rechenberg, Moritz; Walsh, Ryan T.; Watson, Ian; Wilson, Derek J.; Wolf, Esther; Yadav, Manisha; Yazdi, Aliakbar K.; Zhang, Junyi; Zhang, Ying; Santhakumar, Vijayaratnam; Edwards, Aled M.; Barsyte-Lovejoy, Dalia; Schapira, Matthieu; Brown, Peter J.; Halabelian, Levon; Arrowsmith, Cheryl H.

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2024-06-252