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H

Hollis D. Showalter

university of michigan system

H指数:34

被引数:3,947

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Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for the Treatment of Tuberculosis and HIV Coinfection

优化苯并恶嗪类药物以最大程度地减少hPXR激活，以治疗结核病和HIV合并感染

ACS INFECTIOUS DISEASES

IF3.8

2022-06-301

PRE

Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis

优化苯并恶嗪类药物提高结核分枝杆菌RNA聚合酶抑制和治疗结核病的研究

ACS INFECTIOUS DISEASES

IF3.8

2022-06-301

PRE

Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases

2-硝基咪唑并恶嗪和6-硝基咪唑并恶唑的发现和开发用于治疗结核病和被忽视的热带病的最新进展

IF4.6

2020-09-1015

OAAI

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-06-010

OAAI

Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses

SCIENTIFIC REPORTS

IF3.9

2019-07-1519

OAAI

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

PHARMACOLOGY & THERAPEUTICS

IF12.5

2019-03-01149

PREAI

Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2018-11-0131

OAAI

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition

MOLECULAR PHARMACOLOGY

IF3

2018-10-0141

OAAI

Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-05-0452

OAAI

Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2017-09-1233

OAAI

Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects

NEUROPSYCHOPHARMACOLOGY

IF7.1

2017-05-1128

OAAI

Vesicular Glutamate Transporter Inhibitors: Structurally Modified Brilliant Yellow Analogs

NEUROCHEMICAL RESEARCH

IF3.8

2017-03-029

PREAI

New generation tamoxifen analogs as potential treatments for amphetamine abuse

DRUG AND ALCOHOL DEPENDENCE

IF3.6

2017-02-011

PREAI

Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2016-11-0115

OAAI

Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2016-07-0110

OAAI

Structure-based design and development of pyrazolopyridine-based inhibitors of Mcl-1

CANCER RESEARCH

IF16.6

2014-10-010

PRE

3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-05-0789

OAAI

Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2014-02-0115

OAAI

X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-05-3159

OA

Progress in the Synthesis of Canthine Alkaloids and Ring-Truncated Congeners

JOURNAL OF NATURAL PRODUCTS

IF3.6

2013-01-1168

PRE