Mark Searcey - Publications, H-index & Citations

Mark Searcey

University of East Anglia

29H指数

198论文数

2.3K被引数

收录论文 43

发表时间

Advances in triterpene drug discovery

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2024-11-01

OAAI

Goddard, Zoe R.; Searcey, Mark; Osbourn, Anne

Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction

CHEMICAL COMMUNICATIONS

IF4.2

2024-01-01

OAAI

Hayward, Deanne; Goddard, Zoe R.; Cominetti, Marco M. D.; Searcey, Mark; Beekman, Andrew M.

The development of potent, competitive CXCR4 antagonists for the prevention of cancer metastasis 用于预防癌症转移的有效，竞争性CXCR4拮抗剂的开发

BIOCHEMICAL PHARMACOLOGY

IF5.6

2023-12-01

OAAI

Hamshaw, Isabel; Cominetti, Marco M. D.; Lai, Wing-Yee; Searcey, Mark; Mueller, Anja

Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2023-09-01

OAAI

Green, Jonathan; Tinson, Ryan A. J.; Betts, Jacob H. J.; Piras, Monica; Pelut, Aylin; Steverding, Dietmar; Wren, Stephen P.; Searcey, Mark; Troeberg, Linda

Junctions in DNA: underexplored targets for therapeutic intervention DNA中的连接: 治疗干预的未开发目标

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2022-09-01

OAAI

Ivens, Eleanor; Cominetti, Marco M. D.; Searcey, Mark

Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors

MOLECULAR PHARMACOLOGY

IF3

2022-01-01

OAAI

Bidula, Stefan; Bin Nadzirin, Izzuddin; Cominetti, Marco; Hickey, Harry; Cullum, Sean A.; Searcey, Mark; Schmid, Ralf; Fountain, Samuel J.

Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2021-09-21

OAAI

Bin Nadzirin, Izzuddin; Fortuny-Gomez, Anna; Ngum, Neville; Richards, David; Ali, Seema; Searcey, Mark; Fountain, Samuel J.

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-06-01

OAAI

Ortuzar, Natalia; Karu, Kersti; Presa, Daniela; Morais, Goreti R.; Sheldrake, Helen M.; Shnyder, Steve D.; Barnieh, Francis M.; Loadman, Paul M.; Patterson, Laurence H.; Pors, Klaus; Searcey, Mark

Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

RSC MEDICINAL CHEMISTRY

IF3.6

2021-01-01

OAAI

Goddard, Zoe Rachael; Beekman, Andrew Michael; Cominetti, Marco M. D.; O'Connell, Maria A.; Chambrier, Isabelle; Cook, Michael J.; Marin, Maria J.; Russell, David A.; Searcey, Mark

A Peptide-Duocarmycin Conjugate Targeting the Thomsen-Friedenreich Antigen Has Potent and Selective Antitumor Activity

BIOCONJUGATE CHEMISTRY

IF3.9

2020-06-09

OAAI

Cartwright, Oliver Charles; Beekman, Andrew Michael; Cominetti, Marco M. D.; Russell, David A.; Searcey, Mark

Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design (vol 10, pg 4502, 2019)

CHEMICAL SCIENCE

IF7.4

2019-01-01

OAAI

Beekman, Andrew M.; Cominetti, Marco M. D.; Walpole, Samuel J.; Prabhu, Saurabh; O'Connell, Maria A.; Angulo, Jesus; Searcey, Mark

Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design

CHEMICAL SCIENCE

IF7.4

2019-01-01

OAAI

Beekman, Andrew M.; Cominetti, Marco M. D.; Walpole, Samuel J.; Prabhu, Saurabh; O'Connell, Maria A.; Angulo, Jesus; Searcey, Mark

Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

DALTON TRANSACTIONS

IF3.3

2018-01-01

OAAI

Williams, Morwen R. M.; Bertrand, Benoit; Fernandez-Cestau, Julio; Waller, Zoe A. E.; O'Connell, Maria A.; Searcey, Mark; Bochmann, Manfred

Cytotoxicity of Pyrazine-Based Cyclometalated (C∧NPZ∧C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

INORGANIC CHEMISTRY

IF4.7

2017-04-25

OAAI

Bertrand, Benoit; Fernandez-Cestau, Julio; Angulo, Jesus; Cominetti, Marco M. D.; Waller, Zoe A. E.; Searcey, Mark; O'Connell, Maria A.; Bochmann, Manfred

(CNpzC)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties

DALTON TRANSACTIONS

IF3.3

2017-01-01

OAAI

Williams, Morwen; Green, Adam I.; Fernandez-Cestau, Julio; Hughes, David L.; O'Connell, Maria A.; Searcey, Mark; Bertrand, Benoit; Bochmann, Manfred

Unveiling the Three-Finger Pharmacophore Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2016-03-07

OAAI

Angulo, Jesus; Goffin, Sarah A.; Gandhi, Daivik; Searcey, Mark; Howell, Lesley A.

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2015-09-22

OAAI

Stephenson, Michael J.; Howell, Lesley A.; O'Connell, Maria A.; Fox, Keith R.; Adcock, Claire; Kingston, Jenny; Sheldrake, Helen; Pors, Klaus; Collingwood, Stephen P.; Searcey, Mark

Tumor-selective bioactivation of duocarmycin bioprecursors by cytochrome P450 enzymes provides an opportunity to treat drug-resistant breast cancer cells

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Shnyder, Steven D.; Loadman, Paul M.; Sutherland, Mark; Sheldrake, Helen M.; Searcey, Mark; Patterson, Laurence H.; Pors, Klaus

Progress in drugging CYP1A1, 1B1 and CYP2W1 overexpressed in cancer

EUROPEAN JOURNAL OF CANCER

IF7.1

2014-11-01

PREAI

Pors, K.; Le Morvan, V.; Travica, S.; Shnyder, S. D.; Sutherland, M.; Sheldrake, H. M.; Searcey, M.; Johansson, I.; Mkrtchian, S.; Loadman, P. M.; Robert, J.; Ingelman-Sundberg, M.; Patterson, L. H.

CYP2W1 as a novel therapeutic target in colon cancer

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Pors, Klaus; Loadman, Paul M.; Travica, Sandra; Shnyder, Steven D.; Sutherland, Mark; Sheldrake, Helen; Searcey, Mark; Johansson, Inger; Mkrtchian, Souren; Ingelman-Sundberg, Magnus; Patterson, Laurence H.

研究方向