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Francis S. Willard

Eli Lilly and Company

47H指数
143论文数
7.4K被引数
收录论文 55
发表时间
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron
err2024-12-18
err0
PREAI
errSloop, Kyle W.; Cox, Amy L.; Wainscott, David B.; White, Alex; Droz, Brian A.; Stutsman, Cynthia; Showalter, Aaron D.; Suter, Todd M.; Dunbar, James D.; Snider, Brandy M.; O'Farrell, Libbey S.; Hewitt, Natalie; Ruble, J. Craig; Padgett, Leah R.; Woerly, Eric M.; Peterson, Jeffrey A.; Coskun, Tamer; Liu, Zhaomin; Coutant, David E.; Ai, Minrong; Emmerson, Paul J.; Sangwung, Panjamaporn; Willard, Francis S.
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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets
err2023-06-05
err45
errOAAI
errEl, Kimberley; Douros, Jonathan D.; Willard, Francis S.; Novikoff, Aaron; Sargsyan, Ashot; Perez-Tilve, Diego; Wainscott, David B.; Yang, Bin; Chen, Alex; Wothe, Donald; Coupland, Callum; Tschoep, Mattias H.; Finan, Brian; D'Alessio, David A.; Sloop, Kyle W.; Mueller, Timo D.; Campbell, Jonathan E.
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Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 ReceptorS
err2023-03-01
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errOAAI
errWang, Xushan; Hembre, Erik J.; Goldsmith, Paul J.; Beck, James P.; Svensson, Kjell A.; Willard, Francis S.; Bruns, Robert F.
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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept
err2022-09-01
err122
errOAAI
errCoskun, Tamer; Urva, Shweta; Roell, William C.; Qu, Hongchang; Loghin, Corina; Moyers, Julie S.; O'Farrell, Libbey S.; Briere, Daniel A.; Sloop, Kyle W.; Thomas, Melissa K.; Pirro, Valentina; Wainscott, David B.; Willard, Francis S.; Abernathy, Matthew; Morford, LaRonda; Du, Yu; Benson, Charles; Gimeno, Ruth E.; Haupt, Axel; Milicevic, Zvonko
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Structural determinants of dual incretin receptor agonism by tirzepatidetirzepatide双重肠促胰岛素受体激动作用的结构决定因素
err2022-03-25
err52
errOAAI
errSun, Bingfa; Willard, Francis S.; Feng, Dan; Alsina-Fernandez, Jorge; Chen, Qi; Vieth, Michal; Ho, Joseph D.; Showalter, Aaron D.; Stutsman, Cynthia; Ding, Liyun; Suter, Todd M.; Dunbar, James D.; Carpenter, John W.; Mohammed, Faiz Ahmad; Aihara, Eitaro; Brown, Robert A.; Bueno, Ana B.; Emmerson, Paul J.; Moyers, Julie S.; Kobilka, Tong Sun; Coghlan, Matthew P.; Kobilka, Brian K.; Sloop, Kyle W.
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GIP Receptor Agonism Enhances Weight Loss from Either a Biased or an Unbiased GLP-1 Receptor Agonist in DIO Mice
err2021-06-01
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PREAI
errCoghlan, Matthew P.; O'Farrell, Libbey; Showalter, Aaron D.; Wainscott, David B.; Stutsman, Cynthia; Cardona, Guemalli; Cabrera, Over; Alsina-Fernandez, Jorge; Willard, Francis S.; Sloop, Kyle; Coskun, Tamer
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The Novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943 Exhibits Robust Efficacy in Preclinical Models of Obesity and Diabetes
err2021-06-01
err5
PREAI
errCoskun, Tamer; Moyers, Julie S.; Roell, William C.; O'Farrell, Libbey; Regmi, Ajit; Ruan, Xiaoping; Showalter, Aaron D.; Sloop, Kyle; Wainscott, David B.; Willard, Francis S.; Ficorilli, James V.; Cabrera, Over; Urva, Shweta; Cooper, Fariba Norouziyan; Guo, Lili; Alsina-Fernandez, Jorge; Qu, Hongchang
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Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor
err2021-03-15
err14
PREAI
errWillard, Francis S.; Wainscott, David B.; Showalter, Aaron D.; Stutsman, Cynthia; Ma, Wenzhen; Cardona, Guemalli R.; Zink, Richard W.; Corkins, Christopher M.; Chen, Qi; Yumibe, Nathan; Agejas, Javier; Cumming, Graham R.; Minguez, Jose Miguel; Jimenez, Alma; Mateo, Ana, I; Castano, Ana M.; Briere, Daniel A.; Sloop, Kyle W.; Bueno, Ana B.
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Nuisance compounds in cellular assays
err2021-03-01
err37
errOAAI
errDahlin, Jayme L.; Auld, Douglas S.; Rothenaigner, Ina; Haney, Steve; Sexton, Jonathan Z.; Nissink, J. Willem M.; Walsh, Jarrod; Lee, Jonathan A.; Strelow, John M.; Willard, Francis S.; Ferrins, Lori; Baell, Jonathan B.; Walters, Michael A.; Hua, Bruce K.; Hadian, Kamyar; Wagner, Bridget K.
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Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist口服活性非肽激动剂LY3502970激活GLP-1受体的结构基础
err2020-11-11
err96
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errKawai, Takahiro; Sun, Bingfa; Yoshino, Hitoshi; Feng, Dan; Suzuki, Yoshiyuki; Fukazawa, Masanori; Nagao, Shunsuke; Wainscott, David B.; Showalter, Aaron D.; Droz, Brian A.; Kobilka, Tong Sun; Coghlan, Matthew P.; Willard, Francis S.; Kawabe, Yoshiki; Kobilka, Brian K.; Sloop, Kyle W.
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Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation
err2020-09-08
err6
errOAAI
errDey, Asim B.; Khedr, Sherif; Bean, James; Porras, Leah L.; Meredith, Tamika D.; Willard, Francis S.; Hass, Joseph V.; Zhou, Xin; Terashvili, Maia; Jesudason, Cynthia D.; Ruley, Kevin M.; Wiley, Michael R.; Kowala, Mark; Atkinson, Simon J.; Staruschenko, Alexander; Rekhter, Mark D.
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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonistTirzepatide是一种不平衡且有偏见的双重GIP和GLP-1受体激动剂
err2020-09-03
err248
errOAAI
errWillard, Francis S.; Douros, Jonathan D.; Gabe, Maria; Showalter, Aaron D.; Wainscott, David B.; Suter, Todd M.; Capozzi, Megan E.; van der Velden, Wijnand J. C.; Stutsman, Cynthia; Cardona, Guemalli R.; Urva, Shweta; Emmerson, Paul J.; Holst, Jens J.; D'Alessio, David A.; Coghlan, Matthew P.; Rosenkilde, Mette M.; Campbell, Jonathan E.; Sloop, Kyle W.
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Structural insights into probe-dependent positive allosterism of the GLP-1 receptor
err2020-07-20
err60
PREAI
errBueno, Ana B.; Sun, Bingfa; Willard, Francis S.; Feng, Dan; Ho, Joseph D.; Wainscott, David B.; Showalter, Aaron D.; Vieth, Michal; Chen, Qi; Stutsman, Cynthia; Chau, Betty; Ficorilli, James; Agejas, Francisco J.; Cumming, Graham R.; Jimenez, Alma; Rojo, Isabel; Kobilka, Tong Sun; Kobilka, Brian K.; Sloop, Kyle W.
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The Incretin Action of GIP Is Mediated through Both Alpha and Beta Cells
err2020-06-01
err1
PREAI
errEl, Kimberley M.; Capozzi, Megan; Gray, Sarah M.; Brown, Jennifer L.; Willard, Francis S.; Emmerson, Paul; Sloop, Kyle; D'Alessio, David; Campbell, Jonathan
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Incretin-Stimulated Insulin Secretion Is Mediated by Gas Dependent and Independent Mechanisms
err2020-06-01
err0
PREAI
errCapozzi, Megan; Gray, Sarah M.; Emmerson, Paul; Willard, Francis S.; Sloop, Kyle; D'Alessio, David; Campbell, Jonathan
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Selective Phosphodiesterase 1 Inhibitor LY1 Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats
err2020-04-18
err0
errOAAI
errKhedr, Sherif; Dey, Asim; Terashvili, Maia; Porras, Leah; Meredith, Tamika; Willard, Francis; Wiley, Michael; Atkinson, Simon; Kowala, Mark; Staruschenko, Alexander; Rekhter, Mark
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The current state of GPCR-based drug discovery to treat metabolic disease
err2018-03-25
err41
errOAAI
errSloop, Kyle W.; Emmerson, Paul J.; Statnick, Michael A.; Willard, Francis S.
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Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5
err2017-09-11
err21
errOAAI
errFarb, Thomas B.; Adeva, Marta; Beauchamp, Thomas J.; Cabrera, Over; Coates, David A.; Meredith, Tamika DeShea; Droz, Brian A.; Efanov, Alexander; Ficorilli, James V.; Gackenheimer, Susan L.; Martinez-Grau, Maria A.; Molero, Victoriano; Ruano, Gema; Statnick, Michael A.; Suter, Todd M.; Syed, Samreen K.; Toledo, Miguel A.; Willard, Francis S.; Zhou, Xin; Bokvist, Krister B.; Barrett, David G.
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